Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer

International Seminars in Surgical Oncology

Volumn 2, Issue , 2005, Pages

  Watkins, Gareth ^a   Douglas Jones, Anthony G ^b   Mansel, Robert E ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

Breast cancer; Metastasis; Oestrogen receptor; Survival; TBXA2R; TBXAS1; Thromboxane A2 receptor; Thromboxane synthase

Indexed keywords

THROMBOXANE A SYNTHASE 1; THROMBOXANE A2 RECEPTOR; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER GRADING; CANCER SURVIVAL; CANCER TISSUE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; FOLLOW UP; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; LYMPH NODE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SURVIVAL TIME;

EID: 27744513891     PISSN: 14777800     EISSN: 14777800     Source Type: Journal    
DOI: 10.1186/1477-7800-2-23     Document Type: Article

References (35)

1. Karmali RA, Choi K, Otter G, et al. Eicosanoids and metastasis. Experimental aspects in Lewis lung carcinoma. Cancer Biochem Biophys 1986, 9:97-104
2. Horrobin DF. Nutritional and medical importance of γ-linolenic acid. Prog Lipid Res 1992, 31:163-94.
3. Honn KV, Timar J, Rozhin J, Bazaz R, Sameni M, Ziegler G, Sloane BF. A lipoxygenase metabolite, 12-(s)-HETE, stimulates protein-kinase c-mediated release of cathepsin-b from malignant-cells. Exp Cell Res, 1994, 214: 120-130
4. Horrobin DF. Essential fatty acids, lipid peroxidation, and cancer. in 'omega-6 essential fatty acids' edited by Horrobin DF, published by Wiley-Liss, New York, pp351-378, 1990
5. Jiang WG, Douglas-Jones A, Mansel RE: Level of expression of lipoxygenase-5, 12, and 15 and cyclooxygenase in human breast cancer. Prostaglandin Leukotr Ess Fatty Acids 2003, 69: 275-281.
6. Nie D, Che M, Zacharek A, Qiao Y, Li L, Li X, Lamberti M, Tang K, Cai Y, Guo Y, Grignon D, Honn KV : Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility. Am J Pathol 2004, 164: 429-39.
7. Ermert L, Dierkes C, Ermert M. Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin Cancer Res. 2003, 9(5):1604-10.
8. Kurzel F, Hagel Ch, Zapf S, Meissner H, Westphal M, Giese A. Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells. Acta Neurochir (Wien). 2002, 144(1):71-87.
9. Pradono P, Tazawa R, Maemondo M, Tanaka M, Usui K, Saijo Y, Hagiwara K, Nukiwa T. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. Cancer Res. 2002, 1;62(1):63-6.
10. Kleber A, Hartmann RW, Jose J. No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB 231,DU145, and U937 to the basement membrane in an in-vitro model. J Cancer Res Clin Oncol. 2001, 127(12):751-4.
11. Nie D, Lamberti M, Zacharek A, Li L, Szekeres K, Tang K, Chen Y, Honn KV. Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem Biophys Res Commun. 2000, 7;267(1):245-51.
12. Bryant J. Correlation between metastatic patterns in renal cell carcinoma and tissue distribution of thromboxane synthetase. Acta Oncol. 1994, 33(6):708-9.
13. Sanduja SK, Mehta K, Xu XM, Hsu SM, Sanduja R, Wu KK. Differentiation-associated expression of prostaglandin H and thromboxane A synthases in monocytoid leukemia cell lines. Blood. 1991, 15;78(12):3178-85
14. Stamford IF, Melhuish PB, Carroll MA, Corrigan CJ, Patel S, Bennett A. Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation. Br J Cancer. 1986, 54(2):257-63.
15. Honn KV. Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system. Clin Exp Metastasis. 1983, 1(2):103-14.
16. Watkins G, Douglas-Jones A, Bryce R, Mansel RE, Jiang WG. Expression of osteonectin (SPARC) in human breast cancer. Prostaglandins Leukotriences and Essential Fatty Acids, 2005, 72, 267-272
17. Jiang WG, Watkins G, Lane J, Douglas-Jones A, Cunnick GH, Mokbel M, Mansel RE. Prognostic value of Rho familty and and rho-GDIs in breast cancer. Clinical Cancer Research, 2003, 9 (17), 6432-6440.
18. Jiang WG, Watkins G, Fodstad O, Douglas-Jones A, Mokbel K, Mansel RE. Differential expression of the CCN family members Cyr61 from CTGF and Nov in human breast cancer. Endocrine Related Cancers, 2004, 11: 781-791.
19. Jiang WG, Douglas-Jones A, and Mansel RE. Level of expression of PPAR-gamma and its co-activator (PPAR-GCA) in human breast cancer. International Journal of Cancer, 2003, 106, 752-757.
20. Jiang WG, Davies G, Martin TA, Parr C, Watkins G, Mason MD, Mokbel K, and Mansel RE. Molecular targeting of matrilysin and its impact on tumour growth in vivo, the potential implications in breast cancer therapy. Clinical Cancer Research, 2005, 11 (16), 6012-6019
21. Jiang WG, Watkins G, Douglas-Jones A, Mokbel K, Mansel RE, Fodstad O. Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status. International Journal of Cancer. 2005, 117:730-737
22. Yokoyama I, Hayashi S, Kobayashi T, Negita M, Yasutomi M, Uchida K, Takagi H. Prevention of experimental hepatic metastasis with thromboxane synthase inhibitor. Res Exp Med (Berl). 1995, 195(4):209-15.
23. Nardone PA, Slotman GJ, Vezeridis MP. Ketoconazole: a thromboxane synthetase and 5-lipoxygenase inhibitor with antimetastatic activity in B16-F10 melanoma. J Surg Res. 1988, 44(4):425-9
24. Zhao Y, Agarwal VR, Mendelson CR, Simpson ER. Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology. 1996, 137:5739-42
25. Brodie AM, Lu Q, Long BJ, Fulton A, Chen T, Macpherson N, DeJong PC, Blankenstein MA, Nortier JW, Slee PH, van de Ven J, van Gorp JM, Elbers JR, Schipper ME, Blijham GH, Thijssen JH. Aromatase and COX-2 expression in human breast cancers. J Steroid Biochem Mol Biol. 2001, 79:41-7
26. Rubin GL, Zhao Y, Kalus AM, Simpson ER. Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. Cancer Res. 2000, 60:1604-8
27. Giese A, Hagel C, Kim EL, Zapf S, Djawaheri J, Berens ME, Westphal M. Thromboxane synthase regulates the migratory phenotype of human glioma cells. Neuro-oncol. 1999, 1(1):3-13.
28. Chiabrando C, Broggini M, Castelli MG, Cozzi E, Castagnoli MN, Donelli MG, Garattini S, Giavazzi R, Fanelli R. Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. Cancer Res. 1987, 15;47(4):988-91.
29. Davies G, Martin LA, Sacks N, Dowsett M. Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. Ann Oncol. 2002, 13:669-78.
30. Goss PE. Breast cancer prevention - clinical trials strategies involving aromatase inhibitors. J Steroid Biochem Mol Biol. 2003, 86:487-93.
31. Vicenzi E, Lampugnani MG, Bolognese Dalessandro AP, Niewiarowska A, de Gaetano G, Donati MB. Dissociation between thromboxane generation and metastatic potential in cells from a murine fibrosarcoma. Studies with a selective thromboxane synthase inhibitor. Int J Cancer. 1987, 15;39(4):488-91
32. Yamashita T, Shimizu T, Ogata E. Activin A/erythroid differentiation factor induces thromboxane A2 synthetic activity in murine erythroleukemia cells. J Biol Chem. 1991, 25;266(6):3888-92.
33. Ohkawa S, Terao S, Terashita Z, Shibouta Y, Nishikawa K. Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. J Med Chem. 1991, 34(1):267-76.
34. Ihara H, Yokoyama C, Miyata A, Kosaka T, Nusing R, Ullrich V, Tanabe T. Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester. FEBS Lett. 1992, 20;306(2-3):161-4
35. Lee KD, Baek SJ, Shen RF. Multiple factors regulating the expression of human thromboxane synthase gene. Biochem J. 1996, 1;319 (Pt 3):783-91