Animal Models of Depression Vulnerability

Current Topics in Behavioral Neurosciences

Volumn 14, Issue , 2013, Pages 29-54

  Harro, Jaanus ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

Acute and chronic stress; Animal models; Depression; Diathesisstress; Endophenotypic; Inter individual variability; Maternal separation; Predisposition; Resilience

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ANTIDEPRESSANT AGENT; CHLORAMPHETAMINE; ESCITALOPRAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NITRIC OXIDE SYNTHASE; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN; SEROTONIN TRANSPORTER;

ACUTE STRESS; ADULTHOOD; ARTICLE; CHRONIC STRESS; COPING BEHAVIOR; DEPRESSION; DISEASE ASSOCIATION; DYSTHYMIA; EARLY LIFE STRESS; ENDOPHENOTYPE; EXPERIMENTAL MODEL; GENETIC EPIGENESIS; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LIFE SATISFACTION; LIFE STRESS; MAJOR DEPRESSION; MATERNAL DEPRIVATION; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NEUROSIS; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRENATAL STRESS; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; DEPRESSION; DISEASE MODELS, ANIMAL; FEMALE; MALE; STRESS, PSYCHOLOGICAL;

EID: 84880075737     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2012_221     Document Type: Article

References (121)

1. Alttoa A, Kõiv K, Hinsley TA, Brass A, Harro J (2010) Differential gene expression in a rat model of depression based on persistent differences in exploratory activity. Eur Neuropsychopharmacol 20:288-300
2. Anisman H, Merali Z (2003) Cytokines, stress and depressive illness: brain-immune exposure. Ann Med 35:2-11
3. Anisman H, Zacharko RM (1990) Multiple neurochemical and behavioral consequences of stressors: implications for depression. Pharmacol Ther 46:119-136
4. Anisman H, Merali Z, Stead JDH (2008) Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies. Neurosci Biobehav Rev 32:1185-1206
5. 1 knockout mice: involvement in the depressive-like phenotype. Eur Neuropsychopharmacol 21:11-22
6. Belzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125:141-149
7. Bergström A, Jayatissa MN, Mørk A, Wiborg O (2008) Stress sensitivity and resilience in the chronic mild stress rat model of depression: an in situ hybridization study. Brain Res 1196:41-52
8. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868
9. Broadhurst PL, Bignami G (1965) Correlative effects of psychogenetic selection: a study of the Roman high and low avoidance strains of rats. Behav Res Ther 3:273-280
10. Brummelte S, Galea LAM (2010) Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuro-Psychopharmacol Biol Psychiatry 34:766-776
11. Brush FR (2003) Selection for differences in avoidance learning: the Syracuse strains differ in anxiety, not learning ability. Behav Genet 33:677-696
12. Burgdorf J, Panksepp J (2001) Tickling induces reward in adolescent rats. Physiol Behav 72: 167-173
13. Champagne DL, Bagot RC, van Hasselt F, Ramakers G, Meaney MJ, de Kloet ER, Joels M, Krugers H (2008) Maternal care and hippocampal plasticity: evidence for experiencedependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci 28:6037-6045
14. Clark LA, Watson D (1991) Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. J Abnorm Psychol 100:316-336
15. Cryan JF, Mombereau C (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9:326-357.
16. Cryan JF, Slattery DA (2007) Animal models of mood disorders: recent developments. Curr Opin Psychiatry 20:1-7
17. Cryan JF, Markou A, Lucki I (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23:238-245
18. Cunningham JI, Raudensky J, Tonkiss J, Yamamoto BK (2009) MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. Behav Neurosci 123:1076-1084
19. Curzon G (1988) Serotonergic mechanisms of depression. Clin Neuropharmacol 11(S2):S11-S20
20. Davis KL, Panksepp J (2011) The brain's emotional foundations of human personality and the affective neuroscience personality scales. Neurosci Biobehav Rev 35:1946-1958
21. Dillon DG, Holmes AJ, Birk JL, Brooks N, Lyons-Ruth K, Pizzagalli DA (2009) Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood. Biol Psychiatry 66:206-213
22. Drevets WC, Furey ML (2009) Depression and the brain. Encyclopedia of Neuroscience. Elsevier, New York, pp 459-470
23. Duclot F, Hollis F, Darcy MJ, Kabbaj M (2011) Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders. Physiol Behav 104:296-305
24. El Khoury A, Gruber SHM, Mørk A, Mathé AA (2006) Adult life behavioral consequences of early maternal separation are aleviated by escitalopram treatment in a rat model of depression. Prog Neuro-Psychopharmacol Biol Psychiatry 30:535-540
25. El Yacoubi M, Vaugeois J-M (2007) Genetic rodent models of depression. Curr Opin Pharmacol 7:3-7
26. Eysenck HJ (1951) The organization of personality. J Pers 20:101-117
27. Fava M, Kendler KS (2000) Major depressive disorder. Neuron 28:335-341
28. Fernando ABP, Robbins TW (2011) Animal models of neuropsychiatric disorders. Annu Rev Clin Psychol 7:39-61
29. Forbes EE, Dahl RE (2005) Neural systems of positive affect: relevance to understanding child and adolescent depression? Dev Psychopathol 17:827-850
30. Francis DD, Champagne FA, Liu D, Meaney MJ (1999) Maternal care, gene expression, and the development of individual differences in stress reactivity. Ann N Y Acad Sci 896:66-84
31. Frazer A, Morilak DA (2005) What should animal models of depression model? Neurosci Biobehav Rev 29:515-523
32. Garcia-Garcia AL, Elizalde N, Matrov D, Harro J, Wojcik SM, Venzala E, Ramirez MJ, Del Rio J, Tordera RM (2009) Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. Biol Psychiatry 66:275-282
33. Gardner KL, Hale MW, Lightman SL, Plotsky PM, Lowry CA (2009a) Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression. Brain Res 1305: 47-63
34. Gardner KL, Hale MW, Oldfield S, Lightman SL, Plotsky PM, Lowry CA (2009b) Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience 163:991-1001
35. Geschwind N, Nicolson NA, Peeters F, van Os J, Barge-Schaapveld D, Wichers M (2011) Early improvement in positive rather than negative emotion predicts remission from depression after pharmacotherapy. Eur Neuropsychopharmacol 21:241-247
36. Geyer MA, Markou A (1995) Animal models of psychiatric disorders. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 787-798
37. Goel N, Bale TL (2009) Examining the intersection of sex and stress in modeling neuropsychiatric disorders. J Neuroendocrinol 21:415-420
38. Goodman SH (2007) Depression in mothers. Annu Rev Clin Psychol 3:107-135
39. Green AR, Mechan AO, Elliot JM, O'Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ''ecstasy''). Pharmacol Rev 55:463-506
40. Häidkind R, Eller M, Kask A, Harro M, Rinken A, Oreland L, Harro J (2004) Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment. Neurochem Int 45:721-732
41. Harro J (2004) Animal models for better antidepressants: can pathogenetic approaches make a difference? Preclinica 2:402-407
42. Harro J (2010) Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology. Pharmacol Ther 125:402-422
43. Harro J, Oreland L (2001) Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus. Brain Res Rev 38:79-128
44. Harro J, Häidkind R, Harro M, Modiri A-R, Gillberg P-G, Pähkla R, Matto V, Oreland L (1999) Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. Eur Neuropsychopharmacol 10:5-16
45. Harro J, Tõnissaar M, Eller M, Kask A, Oreland L (2001) Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry. Brain Res 899:227-239
46. Harro J, Kanarik M, Matrov D, Panksepp J (2011) Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: relevance of animal affective systems to human disorders, with a focus on resilience to adverse events. Neurosci Biobehav Rev 35:1876-1889
47. Harvey BH, Retief R, Korff A, Wegener G (2006) Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT(2A/C)- receptors. Metab Brain Dis 21:211-220
48. Holmes PV (2003) Rodent models of depression: reexamining validity without anthropomorphic inference. Crit Rev Neurobiol 15:143-174
49. Ingram RE, Luxton DD (2005) Vulnerability-stress models. In: Hankin BL, Abela JRZ (eds) Development of psychopathology. A Vulnerability-Stress Perspective. Sage, Thousand Oaks, pp 32-46
50. Jacobson LH, Cryan JF (2007) Feeling strained? Influence of genetic background on depressionrelated behavior in mice: a review. Behav Genet 37:171-213
51. Kalueff AV, Wheaton M, Murphy DL (2007) What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res 179:1-18
52. Kanarik M, Alttoa A, Matrov D, Kõiv K, Sharp T, Panksepp J, Harro J (2011) Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats. Eur Neuropsychopharmacol 21:92-107
53. Karmiloff-Smith A (2006) The tortuous route from genes to behavior: a neuroconstructivist approach. Cogn Affect Behav Neurosci 6:9-17
54. Kask A, Harro J, Tuomainen P, Rägo L, Männistö PT (1997) Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats. Naunyn-Schmiedeberg's Arch Pharmacol 355:267-272
55. Katz RJ, Roth KA, Carroll BJ (1981) Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev 5:247-251
56. Kendler KS, Kessler RC, Walters EE, MacLean CJ, Sham PC, Neale MC, Heath AC, Eaves LJ (1995) Stressful life events, genetic liability and onset of an episode of major depression in women. Am J Psychiatry 152:833-842
57. Kendler KS, Gatz M, Gardner CO, Pedersen NL (2006) Personality and major depression. A Swedish longitudinal, population-based twin study. Arch Gen Psychiatry 63:1113-1120
58. Ladd CO, Thrivikraman KV, Huot RL, Plotsky PM (2005) Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates. Psychoneuroendocrinology 30:520-533
59. Lanfumey L, Mannoury La Cour C, Froger N, Hamon M (2000) 5-HT-HPA interactions in two models of transgenic mice relevant to major depression. Neurochem Res 25:1199-1206
60. Lavi-Avnon Y, Yadid G, Overstreet DH, Weller A (2005) Abnormal patterns of maternal behavior in a genetic animal model of depression. Physiol Behav 84:607-615
61. Lesch K-P (2007) Linking emotion to the social brain. EMBO Reports 8:S24-S29
62. Levine A, Worrell TR, Zimnisky R, Schmauss C (2012) Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol Dis 45:488-498
63. Maccari S, Darnaudery M, Morley-Fletcher S, Zuena AR, Cinque C, van Reeth O (2003) Prenatal stress and long-term consequences: implications of glucocorticoid hormones. Neurosci Biobehav Rev 27:119-127
64. MacInnes N, Handley SL, Harding GF (2001) Former chronic methylenedioxymethamphetamine (MDMA or ecstasy) users report mild depressive symptoms. J Psychopharmacol 15:181-186
65. Mällo T, Alttoa A, Kõiv K, Tõnissaar M, Eller M, Harro J (2007a) Rats with persistently low or high exploratory activity: behaviour in tests of anxiety and depression, and extracellular levels of dopamine. Behav Brain Res 177:269-281
66. Mällo T, Matrov D, Herm L, Kõiv K, Eller M, Rinken A, Harro J (2007b) Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression. Behav Brain Res 184:57-71
67. Mällo T, Matrov D, Kõiv K, Harro (2009) Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect. Neuroscience 164:963-974
68. Matrov D, Vonk A, Herm L, Rinken A, Harro J (2011) Activating effects of chronic variable stress in rats with different exploratory activity: association with dopamine D1 receptor function in nucleus accumbens. Neuropsychobiology 64:110-122
69. McArthur R, Borsini F (2006) Animal models of depression in drug discovery: a historical perspective. Pharmacol Biochem Behav 84:436-452
70. McKinney WT Jr, Bunney WE Jr (1969) Animal models of depression. I: review of evidence: implications for research. Arch Gen Psychiatry 21:240-248
71. McNish KA, Davis M (1997) Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress. Behav Neurosci 111:80-91
72. Meerlo P, Overkamp GJ, Koolhaas JM (1997) Behavioural and physiological consequences of a single social defeat in Roman high- and low-avoidance rats. Psychoneuroendocrinology 22:155-168
73. Michelsen KA, van den Hove DL, Schmitz C, Segers O, Prickaerts J, Steinbusch HW (2007) Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex. BMC Neurosci 8:107
74. Musazzi L, Mallei A, Tardito D, Gruber SHM, El Khoury A, Racagni G, Mathe AA, Popoli M (2010) Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression. J Psychiat Res 44:511-520
75. Nestler EJ, Gould E, Manji H, Bucan M, Duman RS, Gershenfeld HK, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsly L, Zalcman S (2002) Preclinical models: status of basic research in depression. Biol Psychiatry 52:503-528
76. O'Neill MF, Moore NA (2003) Animal models of depression: are there any? Hum Psychopharmacol 18:239-254
77. Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EMM, Joels M, Lucassen PJ, Krugers H (2010) Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. J Neurosci 30:6635-6645
78. Overstreet DH, Friedman E, Mathe AA, Yadid G (2005) The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. Neurosci Biobehav Rev 29:739-759
79. Oxford Dictionaries (2011) http://oxforddictionaries.com/definition/vulnerable-?q=vulnerability-#vulnerable__3. 31 Dec.2011
80. Oztan O, Aydin C, Isgor C (2011) Stressful environmental and social stimulation in adolescence causes antidepressant-like effects associated with epigenetic induction of the hippocampal BDNF and mossy fibre sprouting in the novelty-seeking phenotype. Neurosci Lett 501: 107-111
81. Palumbo ML, Zorrilla Zubilete MA, Cremaschi GA, Genaro AM (2009) Different effect of chronic stress on learning and memory in BALB/c and C57BL/6 inbred mice: involvement of hippocampal NO production and PKC activity. Stress 12:350-361
82. Panksepp J (1998) Affective Neuroscience: the foundations of human and animal emotions. Oxford University Press, New York
83. Panksepp J, Vilberg T, Bean NJ, Coy DJ, Kastin AJ (1978) Reduction of distress vocalization in chicks by opiate-like peptides. Brain Res Bull 3:663-667
84. Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511-1515
85. Piubelli C, Vighini M, Mathe AA, Domenici E, Carboni L (2011) Escitalopram modulates neuron-remodelling proteins in a rat gene-environment interaction model of depression as revealed by proteomics. Part I: genetic background. Int J Neuropsychopharmacol 14:796-833
86. Pucilowski O, Overstreet DH, Rezvani AH, Janowsky DS (1993) Chronic mild stress-induced anhedonia: greater effect in a genetic rat model of depression. Physiol Behav 54:1215-1220
87. Raudkivi K, Mällo T, Harro J (2012) Effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5-HT in rats with persistent differences in positive affectivity. Acta Neuropsychiatrica (in press)
88. Refojo D, Deussing JM (2012) Animal models of depression. In: Lopez-Munos F, Alamo C (eds) Neurobiology of depression. Frontiers in neuroscience. CRC Press, Boca Raton, pp 1-25
89. Renoir T, Pang TY, Lanfumey L (2012) Drug withdrawal-induced depression: serotonergic and plasticity changes in animal models. Neurosci Biobehav Rev 36:696-726
90. Rezvani AH, Parsian A, Overstreet DH (2002) The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism. Psychiatr Genet 12:1-16
91. Richardson JS (1991) Animal models of depression reflect changing views on the essence and etiology of depressive disorders in humans. Prog Neuro-Psychopharmacol Biol Psychiatry 15:199-204
92. Rosecrans JA, De Feo JJ (1965) The interrelationships between chronic restraint stress and reserpine sedation. Arch Int Pharmacodyn Ther 157:487-498
93. Ruhe HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry 12:331-359
94. Ryan B, Musazzi L, Mallei A, Tardito D, Gruber SHM, El Khoury A, Anwyl R, Racagni G, Mathe AA, Rowan MJ, Popoli M (2009) Remodelling by early-life stress of NMDA receptordependent synaptic plasticity in a gene-environment rat model of depression. Int J Neuropsychopharmacol 12:553-559
95. Samuels BA, Leonardo ED, Gadient R, Williams A, Zhou J, David DJ, Gardier AM, Wong EHF, Hen R (2011) Modeling treatment-resistant depression. Neuropharmacology 61:408-413
96. Sanders-Bush E, Bushing JA, Sulser F (1975) Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms. J Pharmacol Exp Ther 192:33-41
97. Schmidt MV, Scharf SH, Sterlemann V, Ganea K, Liebl C, Holsboer F, Müller MB (2010) High susceptibility to chronic social stress is associated with a depression-like phenotype. Psychoneuroendocrinology 35:635-643
98. Schmidt MV, Wang X-D, Meijer OC (2011) Early life stress paradigms in rodents: potential animal models of depression? Psychopharmacology 214:131-140
99. Shaffery J, Hoffmann R, Armitage R (2003) The neurobiology of depression: perspectives from animal and human sleep studies. Neuroscientist 9:82
100. Simmons DA, Broderick PA (2005) Cytokines, stressors, and clinical depression: augmented adaptation responses underlie depression pathogenesis. Prog Neuro-Psychopharmacol Biol Psychiatry 29:793-807
101. Song C, Leonard BE (2005) The olfactory bulbectomized rat as a model of depression. Neurosci Biobehav Rev 29:627-647
102. Stead JD, Clinton S, Neal C, Schneider J, Jama A, Miller S, Vazguez DM, Watson SJ, Akil H (2006) Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviours. Behav Genet 36:697-712
103. Stedenfeld KA, Clinton SM, Kerman IA, Akil H, Watson SJ, Sved AF (2011) Novelty-seeking behavior predicts vulnerability in a rodent model of depression. Physiol Behav 103:210-216
104. Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P (2004) Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 29:2007-2017
105. Sun M-K, Alkon DL (2006) Differential gender-related vulnerability to depression induction and converging antidepressant responses in rats. J Pharmacol Exp Ther 316:926-932
106. Taffe MA, Huitron-Resendiz S, Schroeder R, Parsons LH, Henriksen SJ, Gold LH (2003) MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys. Pharmacol Biochem Behav 76:141-152
107. Talge NM, Neal C, Glover V (2007) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 48:245-261
108. Tarantino LM, Sullivan PF, Meltzer-Brody S (2011) Using animal models to disentangle the role of genetic, epigenetic, and environmental influences on behavioral outcomes associated with maternal anxiety and depression. Front Psychiatry 2:44
109. Tõnissaar M, Mällo T, Eller M, Häidkind R, Kõiv K, Harro J (2008) Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram. Prog Neuro-Psychopharmacol Biol Psychiatry 32:164-177
110. van den Hove DLA (2006) Prenatal stress and adult psychopathology. University of Maastricht 2006
111. van Donkelaar EL, Kelly PAT, Dawson N, Blokland A, Prickaerts J, Steinbusch HWM, Ferrington L (2010) Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats. J Neurosci Res 88:1557-1568
112. van Praag HM (2001) Anxiety/aggression driven depression: a paradigm of functionalization and verticalization of psychiatric diagnosing. Prog Neuro-Psychopharmacol Biol Psychiatry 12:28-39
113. Ventura R, Cabib S, Puglisi-Allegra S (2002) Genetic susceptibility of mesocortical dopamine to stress determines liability to inhibition of mesoaccumbens dopamine and to behavioural ''despair'' in a mouse model of depression. Neuroscience 115:999-1007
114. Wegener G, Harvey BH, Bonefeld B, Müller HK, Volke V, Overstreet DH, Elfving B (2010) Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression. Int J Neuropsychopharmacol 13:461-473
115. Wikipedia (2011) http://en.wikipedia.org/wiki/Vulnerability. 31 Febr 2011
116. Williams M (2011) Productivity shortfalls in drug discovery: contributions from the preclinical sciences? J Pharmacol Exp Ther 336:3-8
117. Willner P (1990) Animal models of depression: an overview. Pharmacol Ther 45:425-455
118. Willner P (1997) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 134:319-329
119. Willner P, Mitchell PJ (2002) The validity of animal models of predisposition to depression. Behav Pharmacol 13:169-188
120. Willner P, Muscat R, Papp M (1992) Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev 16:525-534
121. Wurtman RJ, Wurtman JJ (1996) Brain serotonin, carbohydrate-craving, obesity and depression. Adv Exp Biol Med 398:35-41