Cytosolic NADPH homeostasis in glucose-starved procyclic trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18494-18505

  Allmann, Stefan ^a   Morand, Pauline ^b   Ebikeme, Charles ^b   Gales, Lara ^c,d,e   Biran, Marc ^b   Hubert, Jane ^b,d,e   Brennand, Ana ^a   Mazet, Muriel ^b   Franconi, Jean Michel ^b   Michels, Paul A M ^f   Portais, Jean Charles ^c,d,e   Boshart, Michael ^a   Bringaud, Frédéric ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b CNRS University Bordeaux Segalen   (France)

^c INSA   (France)

^d UMR792 INGÉNIERIE DES SYSTÈMES BIOLOGIQUES ET DES PROCÉDÉS   (France)

^e CNRS   (France)

^f DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSOLIC; MALIC ENZYMES; PARASITE; PENTOSE PHOSPHATE PATHWAY; STRESS MANAGEMENT; TRYPANOSOMA BRUCEI;

CARBON;

ENZYMES;

GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE ISOMERASE; HYDROGEN PEROXIDE; MALATE DEHYDROGENASE (DECARBOXYLATING); PENTOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CARBON SOURCE; CELL DEATH; CONTROLLED STUDY; GLUCONEOGENESIS; HOMEOSTASIS; MICROBIAL GROWTH; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

GLUCONEOGENESIS; NADPH PRODUCTION; OXIDATIVE STRESS; REDOX REGULATION; TRANSHYDROGENASE-LIKE SHUNT; TRYPANOSOMA BRUCEI; TRYPANOSOME;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOSOL; DEHYDROEPIANDROSTERONE; GLUCONEOGENESIS; GLUCOSE; GLUCOSE-6-PHOSPHATE ISOMERASE; GLUCOSEPHOSPHATE DEHYDROGENASE; HOMEOSTASIS; HYDROGEN PEROXIDE; INSECT PROTEINS; ISOENZYMES; MALATE DEHYDROGENASE; MASS SPECTROMETRY; NADP; PENTOSE PHOSPHATE PATHWAY; RNA INTERFERENCE; TRYPANOSOMA BRUCEI BRUCEI; TSETSE FLIES;

EID: 84880062485     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.462978     Document Type: Article

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