Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids

Molecular and Biochemical Parasitology

Volumn 176, Issue 2, 2011, Pages 112-115

  Gupta, Shreedhara ^a   Cordeiro, Artur T ^c   Michels, Paul A M ^a,b  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

Author keywords

Dehydroepiandrosterone; Epiandrosterone; Genetic complementation; Glucose 6 phosphate dehydrogenase; Leishmania mexicana; Trypanosoma brucei

Indexed keywords

ANTITRYPANOSOMAL AGENT; EPIANDROSTERONE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PRASTERONE; STEROID;

ARTICLE; BLOODSTREAM INFECTION; HUMAN; IMMUNE SYSTEM; LEISHMANIA; LEISHMANIA MEXICANA; NEMATODE; NONHUMAN; PRIORITY JOURNAL; PROTISTAN COMMUNITY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; WILD TYPE;

ANDROSTERONE; CELL LINE; CHAGAS DISEASE; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; LEISHMANIA MEXICANA; LEISHMANIASIS; ORGANISMS, GENETICALLY MODIFIED; PROTOZOAN PROTEINS; SPECIES SPECIFICITY; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS, AFRICAN;

LEISHMANIA MEXICANA; MAMMALIA; NEMATODA; PROTISTA; TRYPANOSOMA BRUCEI;

EID: 79951671918     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.12.006     Document Type: Article

References (22)

1. M.P. Barrett, R.J. Burchmore, and A. Stich The trypanosomiases Lancet 362 2003 1469 1480 (Pubitemid 37352887)
2. S. Nwaka, and A. Hudson Innovative lead discovery strategies for tropical diseases Nat Rev Drug Discov 5 2006 941 955 (Pubitemid 44660607)
3. G.J. Crowther, D. Shanmugam, and S.J. Carmona Identification of attractive drug targets in neglected-disease pathogens using an in silico approach PLoS Negl Trop Dis 4 2010 e804
4. N. Heise, and F.R. Opperdoes Purification, localisation and characterisation of glucose-6-phosphate dehydrogenase of Trypanosoma brucei Mol Biochem Parasitol 99 1999 21 32 (Pubitemid 29127183)
5. F. Duffieux, J. Van Roy, P.A.M. Michels, and F.R. Opperdoes Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6- phosphogluconolactonase J Biol Chem 275 2000 27559 27565
6. M. Igoillo-Esteve, and J.J. Cazzulo The glucose-6-phosphate dehydrogenase from Trypanosoma cruzi: its role in the defense of the parasite against oxidative stress Mol Biochem Parasitol 149 2006 170 181 (Pubitemid 44279091)
7. M. Igoillo-Esteve, D. Maugeri, A.L. Stern, P. Beluardi, and J.J. Cazzulo The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease An Acad Bras Cienc 79 2007 649 663 (Pubitemid 350248758)
8. A.T. Cordeiro, O.H. Thiemann, and P.A.M. Michels Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites Bioorg Med Chem 17 2009 2483 2489
9. A.T. Cordeiro, and O.H. Thiemann 16-Bromoepiandrosterone, an activator of the mammalian immune system, inhibits glucose-6-phosphate dehydrogenase from Trypanosoma cruzi and is toxic to these parasites grown in culture Bioorg Med Chem 18 2010 4762 4768
10. F.R. Opperdoes, and J.P. Szikora In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes Mol Biochem Parasitol 147 2006 193 206
11. A.E. Leroux, D.A. Maugeri, F.R. Opperdoes, J.J. Cazzulo, and C. Nowicki Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei FEMS Microbiol Lett 314 2011 25 33
12. Q. Mo, S.F. Lu, and N.G. Simon Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity J Steroid Biochem Mol 99 2006 50 58
13. D.R. Cameron, and G.D. Braunstein The use of dehydroepiandrosterone therapy in clinical practice Treat Endocrinol 4 2005 95 114 (Pubitemid 40516577)
14. S. Yoshida, A. Honda, and Y Matsuzaki Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines Steroids 68 2003 73 83 (Pubitemid 35418305)
15. P.A. Marks, and J. Banks Inhibition of mammalian glucose-6-phosphate dehydrogenase by steroids Proc Natl Acad Sci USA 46 1960 447 452
16. D. Freilich, S. Ferris, and M. Wallace 16α-Bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth Am J Trop Med Hyg 63 2000 280 283 (Pubitemid 32537564)
17. K.R. Rasmussen, M.J. Arrowood, and M.C. Healey Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats Antimicrob Agents Chemother 36 1992 220 222
18. J. Morales-Montor, S. Baig, R. Mitchell, K. Deway, C. Hallal-Calleros, and R.T. Damian Immunoendocrine interactions during chronic cysticercosis determine male mouse feminization: role of IL-6 J Immunol 167 2001 4527 4533 (Pubitemid 32954331)
19. C.D. dos Santos, M.P. Toldo, and J.C. do Prado Júnior Trypanosoma cruzi: the effects of dehydroepiandrosterone (DHEA) treatment during experimental infection Acta Trop 95 2005 109 115 (Pubitemid 40943361)
20. J.A. Vargas-Villavicencio, C. Larralde, and J. Morales-Montor Treatment with dehydroepiandrosterone in vivo and in vitro inhibits reproduction, growth and viability of Taenia crassiceps metacestodes Int J Parasitol 38 2008 775 781
21. J.C. Carrero, C. Cervantes, N. Moreno-Mendoza, E. Saavedra, J. Morales-Montor, and J.P. Laclette Dehydroepiandrosterone decreases while cortisol increases in vitro growth and viability of Entamoeba histolytica Microbes Infect 8 2006 323 331 (Pubitemid 43214593)
22. M.A. Albert, J.R. Haanstra, and V. Hannaert Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei J Biol Chem 280 2005 28306 28315 (Pubitemid 41105727)