The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20404-20415

  Sheikh, Irshad Ali ^a   Koley, Hemanta ^a   Chakrabarti, Manoj K ^a   Hoque, Kazi Mirajul ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTINYLATION ASSAYS; CURRENT-VOLTAGE RELATIONSHIP; FLUID ACCUMULATION; INTRACELLULAR COMPARTMENTS; SIGNALING PATHWAYS; SURFACE EXPRESSION; THERAPEUTIC VALUES; WHEAT GERM AGGLUTININ;

CYTOLOGY; MODULATION; PHYSIOLOGY; PROTEINS; RAILROAD ROLLING STOCK; TRANSPORT PROPERTIES;

CELLS;

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; ANTIPORTER; CHLORIDE ION; CHOLERA TOXIN; CYCLIC AMP; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP 1; GGTI 298; H 1152; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL 4; INWARDLY RECTIFYING POTASSIUM CHANNEL; RAP1 PROTEIN; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ;

ARTICLE; BIOTINYLATION; CELLULAR DISTRIBUTION; CHANNEL GATING; CHLORIDE TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIARRHEA; HUMAN; HUMAN CELL; IMAGE RECONSTRUCTION; INTESTINE FLUID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

CHLORIDE CHANNELS; CHLORIDE TRANSPORT; CHOLERA TOXIN; CL- SECRETION; CYCLIC AMP (CAMP); DIARRHEA; EPAC1; KCNN4C; POTASSIUM TRANSPORT; RAP1A;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CHLORIDES; CHOLERA TOXIN; CYCLIC AMP; DIARRHEA; EPITHELIAL CELLS; FORSKOLIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; INTESTINAL MUCOSA; MICE; MICROSCOPY, CONFOCAL; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; RAP GTP-BINDING PROTEINS; RAP1 GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84880060224     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.467860     Document Type: Article

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