Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 1, 2008, Pages

  Eid, A H ^a   Chotani, M A ^b   Mitra, S ^b   Miller, T J ^b   Flavahan, N A ^c  

^a LEBANESE INTERNATIONAL UNIVERSITY   (Lebanon)

^b OHIO STATE UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activator protein 1; Adenosine 5 monophosphate; C Jun NH2 terminal kinase; Raynaud's phenomenon; Transcription

Indexed keywords

ALPHA 2C ADRENERGIC RECEPTOR; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; MUTANT PROTEIN; RAP1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; ADRENERGIC RECEPTOR ALPHA(2C); ALPHA 2 ADRENERGIC RECEPTOR; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; DRUG DERIVATIVE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN KINASE INHIBITOR; RAPGEF3 PROTEIN, HUMAN; TELOMERE BINDING PROTEIN; TERF2IP PROTEIN, HUMAN;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; GENE CONTROL; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASOCONSTRICTION; CELL CULTURE; COLD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; SKIN; TRANSACTIVATION; UPREGULATION; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ANTHRACENES; CELLS, CULTURED; COLD; CYCLIC AMP; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FORSKOLIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, ADRENERGIC, ALPHA-2; SIGNAL TRANSDUCTION; SKIN; TELOMERE-BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; UP-REGULATION; VASOCONSTRICTION;

EID: 49849106317     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00084.2008     Document Type: Article

References (39)

1. Altschuler DL, Ribeiro-Neto F. Mitogenic and oncogenic properties of the small G protein Rap1b. Proc Natl Acad Sci USA 95: 7475-7479, 1998.
2. Bailey SR, Eid AH, Mitra S, Flavahan S, Flavahan NA. Rho kinase mediates cold-induced constriction of cutaneous arteries: role of alpha2C-adrenoceptor translocation. Circ Res 94: 1367-1374, 2004.
3. Bailey SR, Mitra S, Flavahan S, Flavahan NA. Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol 289: H243-H250, 2005.
4. Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L. Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem 278: 4778-4785, 2003.
5. Caron E. Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. J Cell Sci 116: 435-440, 2003.
6. 2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol 278: H1075-H1083, 2000.
7. 2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. Am J Physiol Heart Circ Physiol 288: H69-H76, 2005.
8. 2- adrenoceptors in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 286: H59-H67, 2004.
9. 2C-adrenoceptors and cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol 293: H1955-H1961, 2007.
10. Ekenvall L, Lindblad LE, Norbeck O, Etzell BM. α-Adrenoceptors and cold-induced vasoconstriction in human finger skin. Am J Physiol Heart Circ Physiol 255: H1000-H1003, 1988.
11. 2-adrenoceptors. Am J Physiol Heart Circ Physiol 255: H121-H130, 1988.
12. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
13. 2-adrenergic responses in cutaneous veins: role of receptor reserve. Am J Physiol Heart Circ Physiol 249: H950-H955, 1985.
14. Freedman RR, Baer RP, Mayes MD. Blockade of vasospastic attacks by alpha2-adrenergic but not alpha1-adrenergic antagonists in idiopathic Raynaud's disease. Circulation 92: 1448-1451, 1995.
15. Frodin M, Peraldi P, Van Obberghen E. Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J Biol Chem 269: 6207-6214, 1994.
16. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108: 73-81, 2001.
17. He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 280: 33426-33434, 2005.
18. Hochbaum D, Tanos T, Ribeiro-Neto F, Altschuler D, Coso OA. Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger. J Biol Chem 278: 33738-33746, 2003.
19. Honda M, Suzuki M, Nakayama K, Ishikawa T. Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice. Br J Pharmacol 152: 91-100, 2007.
20. Jeyaraj SC, Chotani MA, Mitra S, Gregg HE, Flavahan NA, Morrison KJ. Cooling evokes redistribution of α2C-adrenoceptors from golgi to plasma membrane in transfected HEK293 cells. Mol Pharmacol 60: 1195-1200, 2001.
21. Koyama H, Bornfeldt KE, Fukumoto S, Nishizawa Y. Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation. J Cell Physiol 186: 1-10, 2001.
22. Laroche-Joubert N, Marsy S, Michelet S, Imbert-Teboul M, Doucet A. Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I. J Biol Chem 277: 18598-18604, 2002.
23. Li RC, Cindrova-Davies T, Skepper JN, Sellers LA. Prostacyclin induces apoptosis of vascular smooth muscle cells by a cAMP-mediated inhibition of extracellular signal-regulated kinase activity and can counteract the mitogenic activity of endothelin-1 or basic fibroblast growth factor. Circ Res 94: 759-767, 2004.
24. Liao DF, Duff JL, Daum G, Pelech SL, Berk BC. Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells. Role of Raf. Circ Res 79: 1007-1014, 1996.
25. Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 277: 32799-32806, 2002.
26. Maly FE, Quilliam LA, Dorseuil O, Der CJ, Bokoch GM. Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes. J Biol Chem 269: 18743-18746, 1994.
27. O'Neill E, Kolch W. Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br J Cancer 90: 283-288, 2004.
28. 2-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol 283: R287-R295, 2002.
29. Ribeiro-Neto F, Urbani J, Lemee N, Lou L, Altschuler DL. On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Proc Natl Acad Sci USA 99: 5418-5423, 2002.
30. Sachinidis A, Seul C, Gouni-Berthold I, Seewald S, Ko Y, Vetter H, Fingerle J, Hoppe J. Cholera toxin treatment of vascular smooth muscle cells decreases smooth muscle alpha-actin content and abolishes the platelet-derived growth factor-BB-stimulated DNA synthesis. Br J Pharmacol 130: 1561-1570, 2000.
31. Schaak S, Cayla C, Lymperopoulos A, Flordellis C, Cussac D, Denis C, Paris H. Transcriptional down-regulation of the human alpha2C-adrenergic receptor by cAMP. Mol Pharmacol 58: 821-827, 2000.
32. Schaak S, Devedjian JC, Cayla C, Sender Y, Paris H. Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. Biochem J 328: 431-438, 1997.
33. Schramm K, Niehof M, Radziwill G, Rommel C, Moelling K. Phosphorylation of c-Raf-1 by protein kinase A interferes with activation. Biochem Biophys Res Commun 201: 740-747, 1994.
34. Shen J, DiCorleto PE. ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. Circ Res 102: 448-456, 2008.
35. Stork PJ. Does Rap1 deserve a bad Rap? Trends Biochem Sci 28: 267-275, 2003.
36. Vanhoutte PM. Physical factors of regulation. In: Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle. Bethesda, MD: Am Physiol Soc, 1980, sect. 2, vol. II, chapt. 16, p. 443-474.
37. Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ. Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. Mol Cell Biol 26: 2130-2145, 2006.
38. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262: 1065-1069, 1993.
39. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392: 622-626, 1998.