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1
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0033866622
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Role of Na(+)HCO(3)(-)cotran-sporter NBC1, Na(+)/H(+)exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion
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Jacob P, Christiani S, Rossmann H, et al. Role of Na(+)HCO(3)(-)cotran-sporter NBC1, Na(+)/H(+)exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology 2000; 119:406-419.
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(2000)
Gastroenterology
, vol.119
, pp. 406-419
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Jacob, P.1
Christiani, S.2
Rossmann, H.3
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2
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34147133736
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- exchange and that it plays a significant role in regulating intracellular pH.
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- exchange and that it plays a significant role in regulating intracellular pH.
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3
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55249127294
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- exchanger coupled with NHE3 for electro-neutral NaCI absorption across mammalian small intestine.
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- exchanger coupled with NHE3 for electro-neutral NaCI absorption across mammalian small intestine.
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4
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0031751939
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Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated
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Collins JF, Kiela PR, Xu H, et al. Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated. Am J Physiol 1998; 275:C1143-1150.
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(1998)
Am J Physiol
, vol.275
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Collins, J.F.1
Kiela, P.R.2
Xu, H.3
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5
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38349143138
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+ exchange kinetics different from other apically expressed NHE isoforms.
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+ exchange kinetics different from other apically expressed NHE isoforms.
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6
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42049099655
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Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology(Bethesda)2008; 23:104-114.
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Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology(Bethesda)2008; 23:104-114.
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7
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33646139664
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Coupling modes and toichiometry of CI-/HC03-exchange by slc26a3 and slc26a6
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Shcheynikov N, Wang Y, Park M, et al. Coupling modes and toichiometry of CI-/HC03-exchange by slc26a3 and slc26a6. J Gen Physiol 2006; 127:511-524.
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(2006)
J Gen Physiol
, vol.127
, pp. 511-524
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Shcheynikov, N.1
Wang, Y.2
Park, M.3
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8
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42549134089
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Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte
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Niederer SA, Swietach P, Wilson DA, et al. Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte. Biophys J 2008; 94:2385-2403.
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(2008)
Biophys J
, vol.94
, pp. 2385-2403
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Niederer, S.A.1
Swietach, P.2
Wilson, D.A.3
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9
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40049092462
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Species differences in CI-affinity and in electrogenicity of SLC26A6-mediated oxalate/CI-exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis
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Clark JS, Vandorpe DH, Chernova MN, et al. Species differences in CI-affinity and in electrogenicity of SLC26A6-mediated oxalate/CI-exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol 2008; 586:1291-1306.
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(2008)
J Physiol
, vol.586
, pp. 1291-1306
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Clark, J.S.1
Vandorpe, D.H.2
Chernova, M.N.3
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10
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48449093733
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Singh AK, Sjoblom M, Zheng W, et al. CFTR and its key role in in vivo resting and luminal acid-induced duodenal HC03-secretion. Acta Physiol(Oxf)2008; 193:357-365. This report provides in-vivo evidence for coupled activities of Slc26a6(PAT-1)with CFTR in murine basal, but not acid-stimulated duodenal bicarbonate secretion.
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Singh AK, Sjoblom M, Zheng W, et al. CFTR and its key role in in vivo resting and luminal acid-induced duodenal HC03-secretion. Acta Physiol(Oxf)2008; 193:357-365. This report provides in-vivo evidence for coupled activities of Slc26a6(PAT-1)with CFTR in murine basal, but not acid-stimulated duodenal bicarbonate secretion.
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11
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0033867234
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Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract
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Ameen N, Alexis J, Salas P. Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract. Histochem Cell Biol 2000; 114:69-75.
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(2000)
Histochem Cell Biol
, vol.114
, pp. 69-75
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Ameen, N.1
Alexis, J.2
Salas, P.3
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12
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48249150864
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CFTR inhibition augments NHE3 activity during luminal high C02 exposure in rat duodenal mucosa
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Mizumori M, Choi Y, Guth PH, et al. CFTR inhibition augments NHE3 activity during luminal high C02 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol 2008; 294:G1318-1327.
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(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
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Mizumori, M.1
Choi, Y.2
Guth, P.H.3
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13
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51349085386
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Predicting PDZ domain-peptide interactions from primary sequences
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Chen JR, Chang BH, Allen JE, et al. Predicting PDZ domain-peptide interactions from primary sequences. Nat Biotechnol 2008; 26:1041-1045.
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(2008)
Nat Biotechnol
, vol.26
, pp. 1041-1045
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Chen, J.R.1
Chang, B.H.2
Allen, J.E.3
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14
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0037453510
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Assembly of cell regulatory systems through protein interaction domains
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Pawson T, Nash P. Assembly of cell regulatory systems through protein interaction domains. Science 2003; 300:445-452.
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(2003)
Science
, vol.300
, pp. 445-452
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Pawson, T.1
Nash, P.2
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15
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33751084598
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The emerging role of PDZ adapter proteins for regulation of intestinal ion transport
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A comprehensive review covering the roles of PDZ proteins in the regulation of intestinal anion secretion and electroneutral NaCI absorption
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Lamprecht G, Seidler U. The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol 2006; 291:G766-777. A comprehensive review covering the roles of PDZ proteins in the regulation of intestinal anion secretion and electroneutral NaCI absorption.
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(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.291
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Lamprecht, G.1
Seidler, U.2
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16
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34447629085
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Regulatory binding partners and complexes of NHE3
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A more recent review focuses on the roles of PDZ proteins and their signaling partners in the regulation of NHE3 trafficking and activity
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Donowitz M, Li X. Regulatory binding partners and complexes of NHE3. Physiol Rev 2007; 87:825-872. A more recent review focuses on the roles of PDZ proteins and their signaling partners in the regulation of NHE3 trafficking and activity.
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(2007)
Physiol Rev
, vol.87
, pp. 825-872
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Donowitz, M.1
Li, X.2
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17
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59849104969
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Broere N, Chen M, Cinar A, et al. Defective jejunal and colonic salt absorption and alteredNa(+)/H(+)exchanger 3(NHE3)activity in NHE regulatory factor 1(NHERF1)adaptor protein-deficient mice. Pflugers Arch 2009(in press). This study provides in-vivo evidence for the segment-specific involvement of NHERF-1 in intestinal salt absorption, NHE3 activity and membrane expression, and postulates its limited involvement in regulation of NHE3 by cyclic nucleotides in vivo.
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Broere N, Chen M, Cinar A, et al. Defective jejunal and colonic salt absorption and alteredNa(+)/H(+)exchanger 3(NHE3)activity in NHE regulatory factor 1(NHERF1)adaptor protein-deficient mice. Pflugers Arch 2009(in press). This study provides in-vivo evidence for the segment-specific involvement of NHERF-1 in intestinal salt absorption, NHE3 activity and membrane expression, and postulates its limited involvement in regulation of NHE3 by cyclic nucleotides in vivo.
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18
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34548314536
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Murtazina R, Kovbasnjuk O, Zachos NC, et al. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+)exchanger regulatory factor 1(NHERF1)null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem 2007; 282:25141-25151. This report compares the role of NHERF-1 in cyclic nucleotide-mediated down-regulation of NHE3 in the renal proximal tubules and ileum, and suggests that cAMP inhibition of NHE3 activity in these two tissues is mediated by different mechanisms.
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Murtazina R, Kovbasnjuk O, Zachos NC, et al. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+)exchanger regulatory factor 1(NHERF1)null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem 2007; 282:25141-25151. This report compares the role of NHERF-1 in cyclic nucleotide-mediated down-regulation of NHE3 in the renal proximal tubules and ileum, and suggests that cAMP inhibition of NHE3 activity in these two tissues is mediated by different mechanisms.
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19
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66449131072
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Sullivan S, Alex P, Dassopoulos T, et al. Downregulation of sodium transpor-ters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflamm Bowel Dis 2009; 15:261-274. Data derived from human patients and mouse models of colitis demonstrates that IBD-associated diarrhea may be due to a coordinated downregulation of multiple Na+ transporters and related regulatory proteins, including NHE1, NHE3, Na+/ K+-ATPase, and ENaC, as well as NHERF1, 2, and CIC-5.
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Sullivan S, Alex P, Dassopoulos T, et al. Downregulation of sodium transpor-ters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflamm Bowel Dis 2009; 15:261-274. Data derived from human patients and mouse models of colitis demonstrates that IBD-associated diarrhea may be due to a coordinated downregulation of multiple Na+ transporters and related regulatory proteins, including NHE1, NHE3, Na+/ K+-ATPase, and ENaC, as well as NHERF1, 2, and CIC-5.
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20
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52249089383
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The relative binding affinities of PDZ partners for CFTR: A biochemical basis for efficient endocytic recycling
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Cushing PR, Fellows A, Villone D, et al. The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling. Biochemistry 2008; 47:10084-10098.
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(2008)
Biochemistry
, vol.47
, pp. 10084-10098
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Cushing, P.R.1
Fellows, A.2
Villone, D.3
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21
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38049103594
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Broere N, Hillesheim J, Tuo B, et al. Cystic fibrosis transmembrane conduc-tance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1(NHERF-1)-but Not NHERF-2-deficient mice. J Biol Chem 2007; 282:37575-37584. These studies, performed with NHERF-1 and NHERF-2 knockout mice, provide evidence that NHERF-1 but not NHERF-2 is involved in the formation of CFTR-containing functional complexes responsible for membrane targeting and fine tuning of CFTR function as a cyclic nucleotide-regulated anion channel.
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Broere N, Hillesheim J, Tuo B, et al. Cystic fibrosis transmembrane conduc-tance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1(NHERF-1)-but Not NHERF-2-deficient mice. J Biol Chem 2007; 282:37575-37584. These studies, performed with NHERF-1 and NHERF-2 knockout mice, provide evidence that NHERF-1 but not NHERF-2 is involved in the formation of CFTR-containing functional complexes responsible for membrane targeting and fine tuning of CFTR function as a cyclic nucleotide-regulated anion channel.
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22
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55749088629
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Mechanisms of infectious diarrhea
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A useful review of the mechanisms of diarrhea caused by various pathogens
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Navaneethan U, Giannella RA. Mechanisms of infectious diarrhea. Nat Clin Pract Gastroenterol Hepatol 2008; 5:637-647. A useful review of the mechanisms of diarrhea caused by various pathogens.
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(2008)
Nat Clin Pract Gastroenterol Hepatol
, vol.5
, pp. 637-647
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Navaneethan, U.1
Giannella, R.A.2
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23
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61949259407
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Molecular bases of impaired water and ion movements in inflammatory bowel diseases
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A recent summary on the disturbances in intestinal ion transport in inflammatory bowel diseases
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Martinez-Augustin O, Romero-Calvo I, Suarez MD, et al. Molecular bases of impaired water and ion movements in inflammatory bowel diseases. Inflamm Bowel Dis 2009; 15:114-127. A recent summary on the disturbances in intestinal ion transport in inflammatory bowel diseases.
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(2009)
Inflamm Bowel Dis
, vol.15
, pp. 114-127
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Martinez-Augustin, O.1
Romero-Calvo, I.2
Suarez, M.D.3
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24
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47549095681
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The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity
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Hodges K, Alto NM, Ramaswamy K, et al. The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity. Cell Microbiol 2008; 10:1735-1745.
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(2008)
Cell Microbiol
, vol.10
, pp. 1735-1745
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Hodges, K.1
Alto, N.M.2
Ramaswamy, K.3
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25
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34250186732
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- exchange to a predominantly electrogenic CFTR-mediated anion secretion.
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- exchange to a predominantly electrogenic CFTR-mediated anion secretion.
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26
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64349099223
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Xu H, Chen H, Dong J, Ghishan FK. TNF-a Inhibits Human Intestinal NHE8 Gene Expression in Caco-2 via Tyrosine Kinase Pathway. In Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroentero-logical-Association May 17-22, 2008; San Diego, CA: 2008:A-56.
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Xu H, Chen H, Dong J, Ghishan FK. TNF-a Inhibits Human Intestinal NHE8 Gene Expression in Caco-2 via Tyrosine Kinase Pathway. In Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroentero-logical-Association May 17-22, 2008; San Diego, CA: 2008:A-56.
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+ transport.
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+ transport.
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64349113308
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Kiela PR, Larmonier CB, Midura-Kiela MT, Thurston RD, Ghishan FK. Hyper-sensitivity to DSS-induced mucosal injury in NHE3 knockout mice. In Digestive Disease Week Meeting/108th Annual Meeting of the American- Gastroenterological-Association May 19-24, 2007; Washington, DC, USA: Gastroenterology: 2007: A396. In this study, we demonstrate that changes in the small intestinal and colonic gene expression profile dramatically alter the mucosal response to DSS-mediated epithelial injury, and for the first time show that the small intestine is affected by DSS dependent on the NHE3 status.
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Kiela PR, Larmonier CB, Midura-Kiela MT, Thurston RD, Ghishan FK. Hyper-sensitivity to DSS-induced mucosal injury in NHE3 knockout mice. In Digestive Disease Week Meeting/108th Annual Meeting of the American- Gastroenterological-Association May 19-24, 2007; Washington, DC, USA: Gastroenterology: 2007: A396. In this study, we demonstrate that changes in the small intestinal and colonic gene expression profile dramatically alter the mucosal response to DSS-mediated epithelial injury, and for the first time show that the small intestine is affected by DSS dependent on the NHE3 status.
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