Structure-based discovery of antagonists of nuclear receptor LRH-1

Journal of Biological Chemistry

Volumn 288, Issue 27, 2013, Pages 19830-19844

  Benod, Cindy ^a,b   Carlsson, Jens ^a,c   Uthayaruban, Rubatharshini ^a   Hwang, Peter ^a   Irwin, John J ^a   Doak, Allison K ^a   Shoichet, Brian K ^a   Sablin, Elena P ^a   Fletterick, Robert J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA CELLS; BIOCHEMICAL STUDIES; EXPERIMENTAL EVALUATION; GENE TRANSCRIPTIONS; MOLECULAR DOCKING; NUCLEAR RECEPTORS; TRANSCRIPTIONAL ACTIVITY; TRANSCRIPTIONAL TARGETS;

CELL PROLIFERATION; GENES; LIGANDS; MOLECULES;

TRANSCRIPTION;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIN E; LIVER RECEPTOR HOMOLOG 1; LIVER RECEPTOR HOMOLOG 1 ANTAGONIST; PROTEIN INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; MUTAGENESIS; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE; TRANSCRIPTION REGULATION;

ANTAGONIST; HORMONE RECEPTORS; INHIBITOR; LIGAND-BINDING PROTEIN; LRH-1; MOLECULAR DOCKING; NR5A2; NUCLEAR RECEPTORS; TRANSCRIPTION REGULATION;

CELL PROLIFERATION; CYCLIN E; DRUG DISCOVERY; HEK293 CELLS; HELA CELLS; HUMANS; MOLECULAR PROBES; NEOPLASMS; ONCOGENE PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880053626     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.411686     Document Type: Article

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