Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2266-2281

  Whitby, Richard J ^a   Stec, Jozef ^a   Blind, Raymond D ^b   Dixon, Sally ^a   Leesnitzer, Lisa M ^c   Orband Miller, Lisa A ^c   Williams, Shawn P ^c   Willson, Timothy M ^c   Xu, Robert ^c   Zuercher, William J ^c   Cai, Fang ^b   Ingraham, Holly A ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (OCT 4 EN 4 YL) 1 PHENYLAMINO 2 PHENYLBICYCLO[3.3.0]OCT 2 ENE; BICYCLO[3.3.0]OCTANE DERIVATIVE; LIVER RECEPTOR HOMOLOG 1; ORPHAN NUCLEAR RECEPTOR; RJW 100; RJW 101; RJW 102; RJW 103; STEROIDOGENIC FACTOR 1; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID; SMALL MOLECULE LIBRARIES; STEROIDOGENIC FACTOR 1; TRANSCRIPTIONAL ACTIVATION;

EID: 79953786258     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1014296     Document Type: Article

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