-
1
-
-
79959560633
-
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects
-
Lee, J.M. et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474, 506-510 (2011).
-
(2011)
Nature
, vol.474
, pp. 506-510
-
-
Lee, J.M.1
-
2
-
-
20844456958
-
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
-
Ortlund, E.A. et al. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat. Struct. Mol. Biol. 12, 357-363 (2005).
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 357-363
-
-
Ortlund, E.A.1
-
3
-
-
13544263313
-
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
-
Krylova, I.N. et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120, 343-355 (2005).
-
(2005)
Cell
, vol.120
, pp. 343-355
-
-
Krylova, I.N.1
-
4
-
-
22144487356
-
Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
-
Li, Y. et al. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc. Natl. Acad. Sci. USA 102, 9505-9510 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9505-9510
-
-
Li, Y.1
-
5
-
-
79958265623
-
Emerging actions of the nuclear receptor LRH-1 in the gut
-
Fernandez-Marcos, P.J., Auwerx, J. & Schoonjans, K. Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim. Biophys. Acta 1812, 947-955 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, pp. 947-955
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
Schoonjans, K.3
-
6
-
-
52049108214
-
Liver receptor homolog-1, an emerging metabolic modulator
-
Lee, Y.K. & Moore, D.D. Liver receptor homolog-1, an emerging metabolic modulator. Front. Biosci. 13, 5950-5958 (2008).
-
(2008)
Front. Biosci.
, vol.13
, pp. 5950-5958
-
-
Lee, Y.K.1
Moore, D.D.2
-
7
-
-
0031010818
-
Steroidogenic factor 1: A key determinant of endocrine development and function
-
Parker, K.L. & Schimmer, B.P. Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr. Rev. 18, 361-377 (1997).
-
(1997)
Endocr. Rev.
, vol.18
, pp. 361-377
-
-
Parker, K.L.1
Schimmer, B.P.2
-
8
-
-
78149337402
-
Canonical Wnt/beta-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression
-
Wagner, R.T., Xu, X., Yi, F., Merrill, B.J. & Cooney, A.J. Canonical Wnt/beta-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells 28, 1794-1804 (2010).
-
(2010)
Stem Cells
, vol.28
, pp. 1794-1804
-
-
Wagner, R.T.1
Xu, X.2
Yi, F.3
Merrill, B.J.4
Cooney, A.J.5
-
9
-
-
20244381404
-
Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development
-
Gu, P. et al. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol. Cell Biol. 25, 3492-3505 (2005).
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 3492-3505
-
-
Gu, P.1
-
10
-
-
0037036456
-
Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes
-
Clyne, C.D., Speed, C.J., Zhou, J. & Simpson, E.R. Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J. Biol. Chem. 277, 20591-20597 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20591-20597
-
-
Clyne, C.D.1
Speed, C.J.2
Zhou, J.3
Simpson, E.R.4
-
11
-
-
1542512538
-
Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue
-
Clyne, C.D. et al. Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue. Mol. Cell Endocrinol. 215, 39-44 (2004).
-
(2004)
Mol. Cell Endocrinol.
, vol.215
, pp. 39-44
-
-
Clyne, C.D.1
-
12
-
-
19944430970
-
Interactions between prostaglandin E-2, liver receptor homologue-1, and aromatase in breast cancer
-
Zhou, J. et al. Interactions between prostaglandin E-2, liver receptor homologue-1, and aromatase in breast cancer. Cancer Res. 65, 657-663 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 657-663
-
-
Zhou, J.1
-
13
-
-
78649843419
-
The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion
-
Chand, A.L., Herridge, K.A., Thompson, E.W. & Clyne, C.D. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion. Endocr. Relat. Cancer 17, 965-975 (2010).
-
(2010)
Endocr. Relat. Cancer
, vol.17
, pp. 965-975
-
-
Chand, A.L.1
Herridge, K.A.2
Thompson, E.W.3
Clyne, C.D.4
-
14
-
-
28744459007
-
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene
-
Annicotte, J.S. et al. The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene 24, 8167-8175 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 8167-8175
-
-
Annicotte, J.S.1
-
15
-
-
79958193092
-
The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells
-
Thiruchelvam, P.T. et al. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast Cancer Res. Treat. 127, 385-396 (2011).
-
(2011)
Breast Cancer Res. Treat.
, vol.127
, pp. 385-396
-
-
Thiruchelvam, P.T.1
-
16
-
-
3242784885
-
Mechanism of the nuclear receptor molecular switch
-
Nagy, L. & Schwabe, J.W. Mechanism of the nuclear receptor molecular switch. Trends Biochem. Sci. 29, 317-324 (2004).
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 317-324
-
-
Nagy, L.1
Schwabe, J.W.2
-
17
-
-
0033637121
-
A regulatory cascade of the nuclear receptors FXR SHP-1 and LRH-1 represses bile acid biosynthesis
-
Goodwin, B. et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6, 517-526 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 517-526
-
-
Goodwin, B.1
-
18
-
-
57449090890
-
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1
-
Sablin, E.P. et al. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc. Natl. Acad. Sci. USA 105, 18390-18395 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18390-18395
-
-
Sablin, E.P.1
-
19
-
-
0038503976
-
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
-
Sablin, E.P., Krylova, I.N., Fletterick, R.J. & Ingraham, H.A. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol. Cell 11, 1575-1585 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1575-1585
-
-
Sablin, E.P.1
Krylova, I.N.2
Fletterick, R.J.3
Ingraham, H.A.4
-
20
-
-
27944442420
-
Orphan nuclear receptors adopted by crystallography
-
Ingraham, H.A. & Redinbo, M.R. Orphan nuclear receptors adopted by crystallography. Curr. Opin. Struct. Biol. 15, 708-715 (2005).
-
(2005)
Curr. Opin. Struct. Biol.
, vol.15
, pp. 708-715
-
-
Ingraham, H.A.1
Redinbo, M.R.2
-
21
-
-
0348224159
-
Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1
-
Xu, P.L., Kong, Y.Y., Xie, Y.H. & Wang, Y. Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/hLRH-1. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35, 897-903 (2003).
-
(2003)
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
, vol.35
, pp. 897-903
-
-
Xu, P.L.1
Kong, Y.Y.2
Xie, Y.H.3
Wang, Y.4
-
22
-
-
21144448184
-
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
-
Wang, W. et al. The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc. Natl. Acad. Sci. USA 102, 7505-7510 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7505-7510
-
-
Wang, W.1
-
23
-
-
13944276441
-
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1
-
Li, Y. et al. Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Mol. Cell 17, 491-502 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 491-502
-
-
Li, Y.1
-
24
-
-
0035102591
-
Probing conformational changes in the estrogen receptor: Evidence for a partially unfolded intermediate facilitating ligand binding and release
-
Gee, A.C. & Katzenellenbogen, J.A. Probing conformational changes in the estrogen receptor: evidence for a partially unfolded intermediate facilitating ligand binding and release. Mol. Endocrinol. 15, 421-428 (2001).
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 421-428
-
-
Gee, A.C.1
Katzenellenbogen, J.A.2
-
25
-
-
84856007344
-
Structural basis of coactivation of liver receptor homolog-1 by β-catenin
-
Yumoto, F. et al. Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc. Natl. Acad. Sci. USA 109, 143-148 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 143-148
-
-
Yumoto, F.1
-
26
-
-
67749119818
-
Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain
-
Jasuja, R. et al. Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain. Mol. Endocrinol. 23, 1231-1241 (2009).
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 1231-1241
-
-
Jasuja, R.1
-
27
-
-
76749125430
-
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
-
Venteclef, N. et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Genes Dev. 24, 381-395 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 381-395
-
-
Venteclef, N.1
-
28
-
-
79953786258
-
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
-
Whitby, R.J. et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J. Med. Chem. 54, 2266-2281 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 2266-2281
-
-
Whitby, R.J.1
-
29
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
30
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G.N., Vagin, A.A. & Dodson, E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240-255 (1997).
-
(1997)
Acta Crystallogr. D Biol. Crystallogr.
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
31
-
-
0037779018
-
A graphical user interface to the CCP4 program suite
-
Potterton, E., Briggs, P., Turkenburg, M. & Dodson, E. A graphical user interface to the CCP4 program suite. Acta Crystallogr. D Biol. Crystallogr. 59, 1131-1137 (2003).
-
(2003)
Acta Crystallogr. D Biol. Crystallogr.
, vol.59
, pp. 1131-1137
-
-
Potterton, E.1
Briggs, P.2
Turkenburg, M.3
Dodson, E.4
-
33
-
-
77949535720
-
And development of Coot
-
Emsley, P., Lohkamp, B., Scott, W.G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Features, C.K.4
-
34
-
-
74549178560
-
MolProbity: All-atom structure validation for macromolecular crystallography
-
Chen, V.B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66, 12-21 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
-
35
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh, E.G. & Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917 (1959).
-
(1959)
Can. J. Biochem. Physiol.
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
36
-
-
0026672292
-
Improved procedures for the determination of lipid phosphorus by malachite green
-
Zhou, X. & Arthur, G. Improved procedures for the determination of lipid phosphorus by malachite green. J. Lipid Res. 33, 1233-1236 (1992).
-
(1992)
J. Lipid Res.
, vol.33
, pp. 1233-1236
-
-
Zhou, X.1
Arthur, G.2
-
37
-
-
84855690465
-
Prediction of protein secondary structure from circular dichroism using theoretically derived spectra
-
doi:10.1002/prot.23188, 14 September 2011
-
Louis-Jeune, C., Andrade-Navarro, M.A. & Perez-Iratxeta, C. Prediction of protein secondary structure from circular dichroism using theoretically derived spectra. Proteins published online, doi:10.1002/prot.23188 (14 September 2011).
-
Proteins Published Online
-
-
Louis-Jeune, C.1
Andrade-Navarro, M.A.2
Perez-Iratxeta, C.3
-
38
-
-
33144462544
-
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry
-
Chalmers, M.J. et al. Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal. Chem. 78, 1005-1014 (2006).
-
(2006)
Anal. Chem.
, vol.78
, pp. 1005-1014
-
-
Chalmers, M.J.1
|