Snapshots of ispinesib-induced conformational changes in the mitotic kinesin eg5

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18588-18598

  Kaan, Hung Yi Kristal ^a   Major, Jennifer ^b   Tkocz, Katarzyna ^a   Kozielski, Frank ^a   Rosenfeld, Steven S ^b  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SITES; CONFORMATIONAL CHANGE; KEY REGULATORS; MITOTIC KINESIN EG5; SMALL MOLECULE INHIBITOR;

BIOCHEMISTRY; BIOLOGY;

CONFORMATIONS;

ADENOSINE TRIPHOSPHATE; EG5 KINESIN; ISPINESIB; KINESIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); KINESIN; KINETICS; MITOSIS;

ALGORITHMS; BENZAMIDES; BINDING SITES; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINESIN; KINETICS; MITOSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES;

EID: 84880052495     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.462648     Document Type: Article

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