Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments

Circulation Research

Volumn 112, Issue 12, 2013, Pages 1542-1556

  Patel, Vaibhav B ^a   Wang, Zuocheng ^a   Fan, Dong ^a   Zhabyeyev, Pavel ^a   Basu, Ratnadeep ^a   Das, Subhash K ^a   Wang, Wang ^a   Desaulniers, Jessica ^a   Holland, Steven M ^b   Kassiri, Zamaneh ^a   Oudit, Gavin Y ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

actin cytoskeleton; cortactin; heart failure; mechanotransduction; p47phox; pressure overload; remodeling

Indexed keywords

BETA CATENIN; CORTACTIN; F ACTIN; FOCAL ADHESION KINASE; G ACTIN; MYOSIN HEAVY CHAIN BETA; NERVE CELL ADHESION MOLECULE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; ACTIN; CADHERIN; CATNB PROTEIN, MOUSE; CDH2 PROTEIN, MOUSE; CYBB PROTEIN, MOUSE; FOCAL ADHESION KINASE 1; MEMBRANE PROTEIN; NEUTROPHIL CYTOSOLIC FACTOR 1; PTK2 PROTEIN, MOUSE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; BIOMECHANICAL STRESS; CARDIOVASCULAR MORTALITY; CELL ADHESION; COMPARATIVE STUDY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOSKELETON; ENZYME PHOSPHORYLATION; HEART EJECTION FRACTION; HEART FAILURE; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MALE; MECHANOTRANSDUCTION; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS; SUDDEN CARDIAC DEATH; SYSTOLIC DYSFUNCTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BIOMECHANICS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; MECHANICAL STRESS; METABOLISM; MOUSE MUTANT; P47PHOX; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; POLYMERIZATION; PRESSURE OVERLOAD; REMODELING; TIME;

ACTIN CYTOSKELETON; CORTACTIN; HEART FAILURE; MECHANOTRANSDUCTION; P47PHOX; PRESSURE OVERLOAD; REMODELING;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; BETA CATENIN; BIOMECHANICS; CADHERINS; CELLS, CULTURED; CORTACTIN; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY, DOPPLER; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION KINASE 1; HEART FAILURE; HUMANS; IMMUNOPRECIPITATION; MALE; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; POLYMERIZATION; REACTIVE OXYGEN SPECIES; STRESS, MECHANICAL; TIME FACTORS; VENTRICULAR REMODELING;

EID: 84880042028     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300299     Document Type: Article

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