Deletion of p47 phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse

Diabetologia

Volumn 55, Issue 9, 2012, Pages 2522-2532

  Liu, G C ^a   Fang, F ^a   Zhou, J ^a   Koulajian, K ^a   Yang, S ^a   Lam, L ^a   Reich, H N ^a   John, R ^b   Herzenberg, A M ^b   Giacca, A ^a   Oudit, G Y ^c   Scholey, J W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Beta cell dysfunction; Diabetes; Diabetic nephropathy; Endoplasmic reticulum (ER) stress; NADPH oxidase; Oxidative stress; p47 phox; Reactive oxygen species

Indexed keywords

ALBUMIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NEUTROPHIL CYTOSOLIC FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ARTICLE; DIABETIC NEPHROPATHY; DISEASE COURSE; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; GENE DELETION; GENE EXPRESSION; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY HYPERTROPHY; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; GLOMERULUS; INJURY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; PATHOPHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERGLYCEMIA; KIDNEY GLOMERULUS; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84866084135     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2586-1     Document Type: Article

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