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Volumn 173, Issue 2, 2013, Pages 343-354

Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA

Author keywords

Immunosuppression; Induction; Interleukin 2 receptor signalling; Mesenchymal stem cells; Regulatory T cells

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84879997952     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12120     Document Type: Article
Times cited : (80)

References (76)
  • 1
    • 34548508410 scopus 로고    scopus 로고
    • Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities
    • Hoogduijn MJ, Crop MJ, Peeters AM etal. Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities. Stem Cells Dev 2007; 16:597-604.
    • (2007) Stem Cells Dev , vol.16 , pp. 597-604
    • Hoogduijn, M.J.1    Crop, M.J.2    Peeters, A.M.3
  • 2
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC etal. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 3
    • 18744373595 scopus 로고    scopus 로고
    • Human adipose tissue is a source of multipotent stem cells
    • Zuk PA, Zhu M, Ashjian P etal. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13:4279-4295.
    • (2002) Mol Biol Cell , vol.13 , pp. 4279-4295
    • Zuk, P.A.1    Zhu, M.2    Ashjian, P.3
  • 4
    • 80051724241 scopus 로고    scopus 로고
    • Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy
    • Antonucci I, Stuppia L, Kaneko Y etal. Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy. Cell Transplant 2011; 20:789-795.
    • (2011) Cell Transplant , vol.20 , pp. 789-795
    • Antonucci, I.1    Stuppia, L.2    Kaneko, Y.3
  • 5
    • 84871531570 scopus 로고    scopus 로고
    • Mesenchymal stem cell treatment for autoimmune diseases: a critical review
    • Figueroa FE, Carrion F, Villanueva S, Khoury M. Mesenchymal stem cell treatment for autoimmune diseases: a critical review. Biol Res 2012; 45:269-277.
    • (2012) Biol Res , vol.45 , pp. 269-277
    • Figueroa, F.E.1    Carrion, F.2    Villanueva, S.3    Khoury, M.4
  • 7
    • 84865355509 scopus 로고    scopus 로고
    • Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders
    • Bernardo ME, Fibbe WE. Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders. Ann NY Acad Sci 2012; 1266:107-117.
    • (2012) Ann NY Acad Sci , vol.1266 , pp. 107-117
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 8
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    • Le Blanc K, Frassoni F, Ball L etal. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 9
    • 56149110595 scopus 로고    scopus 로고
    • Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells
    • Casiraghi F, Azzollini N, Cassis P etal. Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. J Immunol 2008; 181:3933-3946.
    • (2008) J Immunol , vol.181 , pp. 3933-3946
    • Casiraghi, F.1    Azzollini, N.2    Cassis, P.3
  • 10
    • 56049100237 scopus 로고    scopus 로고
    • Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate
    • Popp FC, Eggenhofer E, Renner P etal. Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate. Transpl Immunol 2008; 20:55-60.
    • (2008) Transpl Immunol , vol.20 , pp. 55-60
    • Popp, F.C.1    Eggenhofer, E.2    Renner, P.3
  • 11
    • 81155150122 scopus 로고    scopus 로고
    • Improvement of skin-graft survival after autologous transplantation of adipose-derived stem cells in rats
    • Zografou A, Tsigris C, Papadopoulos O etal. Improvement of skin-graft survival after autologous transplantation of adipose-derived stem cells in rats. J Plast Reconstr Aesthet Surg 2011; 64:1647-1656.
    • (2011) J Plast Reconstr Aesthet Surg , vol.64 , pp. 1647-1656
    • Zografou, A.1    Tsigris, C.2    Papadopoulos, O.3
  • 13
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M, Cosmi L, Angeli R etal. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24:386-398.
    • (2006) Stem Cells , vol.24 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3
  • 14
    • 79952482065 scopus 로고    scopus 로고
    • Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells
    • Crop MJ, Baan CC, Korevaar SS etal. Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells. Clin Exp Immunol 2010; 162:474-486.
    • (2010) Clin Exp Immunol , vol.162 , pp. 474-486
    • Crop, M.J.1    Baan, C.C.2    Korevaar, S.S.3
  • 15
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M etal. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30:42-48.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3
  • 16
    • 30144440925 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate B-cell functions
    • Corcione A, Benvenuto F, Ferretti E etal. Human mesenchymal stem cells modulate B-cell functions. Blood 2006; 107:367-372.
    • (2006) Blood , vol.107 , pp. 367-372
    • Corcione, A.1    Benvenuto, F.2    Ferretti, E.3
  • 18
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105:1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 19
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • Jiang XX, Zhang Y, Liu B etal. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105:4120-4126.
    • (2005) Blood , vol.105 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3
  • 20
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M etal. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99:3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 21
    • 65549154385 scopus 로고    scopus 로고
    • Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients
    • Crop MJ, Baan CC, Korevaar SS etal. Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients. Transplantation 2009; 87:896-906.
    • (2009) Transplantation , vol.87 , pp. 896-906
    • Crop, M.J.1    Baan, C.C.2    Korevaar, S.S.3
  • 22
    • 18844404360 scopus 로고    scopus 로고
    • Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    • Augello A, Tasso R, Negrini SM etal. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 2005; 35:1482-1490.
    • (2005) Eur J Immunol , vol.35 , pp. 1482-1490
    • Augello, A.1    Tasso, R.2    Negrini, S.M.3
  • 23
    • 22144473736 scopus 로고    scopus 로고
    • Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells
    • Groh ME, Maitra B, Szekely E, Koc ON. Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. Exp Hematol 2005; 33:928-934.
    • (2005) Exp Hematol , vol.33 , pp. 928-934
    • Groh, M.E.1    Maitra, B.2    Szekely, E.3    Koc, O.N.4
  • 24
    • 79959938424 scopus 로고    scopus 로고
    • Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells
    • Deuse T, Stubbendorff M, Tang-Quan K etal. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant 2011; 20:655-667.
    • (2011) Cell Transplant , vol.20 , pp. 655-667
    • Deuse, T.1    Stubbendorff, M.2    Tang-Quan, K.3
  • 25
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • Sato K, Ozaki K, Oh I etal. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 2007; 109:228-234.
    • (2007) Blood , vol.109 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3
  • 26
    • 34547647603 scopus 로고    scopus 로고
    • Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G
    • Nasef A, Mathieu N, Chapel A etal. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation 2007; 84:231-237.
    • (2007) Transplantation , vol.84 , pp. 231-237
    • Nasef, A.1    Mathieu, N.2    Chapel, A.3
  • 27
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103:4619-4621.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 28
    • 78650026309 scopus 로고    scopus 로고
    • The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
    • Hoogduijn MJ, Popp F, Verbeek R etal. The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy. Int Immunopharmacol 2010; 10:1496-1500.
    • (2010) Int Immunopharmacol , vol.10 , pp. 1496-1500
    • Hoogduijn, M.J.1    Popp, F.2    Verbeek, R.3
  • 29
    • 84873022590 scopus 로고    scopus 로고
    • Interaction between adipose-tissue derived mesenchymal stem cells and regulatory T cells
    • Engela AU, Baan CC, Peeters AM, Weimar W, Hoogduijn MJ. Interaction between adipose-tissue derived mesenchymal stem cells and regulatory T cells. Cell Transplant 2012; 22:41-54.
    • (2012) Cell Transplant , vol.22 , pp. 41-54
    • Engela, A.U.1    Baan, C.C.2    Peeters, A.M.3    Weimar, W.4    Hoogduijn, M.J.5
  • 31
    • 38949175025 scopus 로고    scopus 로고
    • Mesenchymal cells recruit and regulate T regulatory cells
    • Di Ianni M, Del Papa B, De Ioanni M etal. Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol 2008; 36:309-318.
    • (2008) Exp Hematol , vol.36 , pp. 309-318
    • Di Ianni, M.1    Del Papa, B.2    De Ioanni, M.3
  • 32
    • 60449100851 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    • Gonzalez MA, Gonzalez-Rey E, Rico L, Buscher D, Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 2009; 136:978-989.
    • (2009) Gastroenterology , vol.136 , pp. 978-989
    • Gonzalez, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Buscher, D.4    Delgado, M.5
  • 33
    • 67650932291 scopus 로고    scopus 로고
    • Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
    • Ge W, Jiang J, Baroja ML etal. Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance. Am J Transplant 2009; 9:1760-1772.
    • (2009) Am J Transplant , vol.9 , pp. 1760-1772
    • Ge, W.1    Jiang, J.2    Baroja, M.L.3
  • 34
    • 79952042164 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    • Kavanagh H, Mahon BP. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 2011; 66:523-531.
    • (2011) Allergy , vol.66 , pp. 523-531
    • Kavanagh, H.1    Mahon, B.P.2
  • 35
    • 79951924294 scopus 로고    scopus 로고
    • Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility
    • Perico N, Casiraghi F, Introna M etal. Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol 2011; 6:412-422.
    • (2011) Clin J Am Soc Nephrol , vol.6 , pp. 412-422
    • Perico, N.1    Casiraghi, F.2    Introna, M.3
  • 36
    • 84859390119 scopus 로고    scopus 로고
    • Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    • Bilate AM, Lafaille JJ. Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol 2012; 30:733-758.
    • (2012) Annu Rev Immunol , vol.30 , pp. 733-758
    • Bilate, A.M.1    Lafaille, J.J.2
  • 37
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • Baron U, Floess S, Wieczorek G etal. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 2007; 37:2378-2389.
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3
  • 38
    • 84872914245 scopus 로고    scopus 로고
    • Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion
    • Eggenhofer E, Benseler V, Kroemer A etal. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol 2012; 3:297.
    • (2012) Front Immunol , vol.3 , pp. 297
    • Eggenhofer, E.1    Benseler, V.2    Kroemer, A.3
  • 39
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • Wieczorek G, Asemissen A, Model F etal. Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res 2009; 69:599-608.
    • (2009) Cancer Res , vol.69 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3
  • 40
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 41
    • 78650827566 scopus 로고    scopus 로고
    • Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression
    • Ge W, Jiang J, Arp J, Liu W, Garcia B, Wang H. Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2, 3-dioxygenase expression. Transplantation 2010; 90:1312-1320.
    • (2010) Transplantation , vol.90 , pp. 1312-1320
    • Ge, W.1    Jiang, J.2    Arp, J.3    Liu, W.4    Garcia, B.5    Wang, H.6
  • 42
    • 84865578483 scopus 로고    scopus 로고
    • Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation
    • Casiraghi F, Azzollini N, Todeschini M etal. Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation. Am J Transplant 2012; 12:2373-2383.
    • (2012) Am J Transplant , vol.12 , pp. 2373-2383
    • Casiraghi, F.1    Azzollini, N.2    Todeschini, M.3
  • 44
    • 10344220512 scopus 로고    scopus 로고
    • CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    • Curotto de Lafaille MA, Lino AC, Kutchukhidze N, Lafaille JJ. CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion. J Immunol 2004; 173:7259-7268.
    • (2004) J Immunol , vol.173 , pp. 7259-7268
    • Curotto de Lafaille, M.A.1    Lino, A.C.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 45
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille MA, Lafaille JJ. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 2009; 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 46
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V etal. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006; 126:375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 47
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM etal. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007; 445:931-935.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 48
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007; 445:936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 49
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M, Yaguchi H, Ohkura N etal. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007; 446:685-689.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3
  • 50
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P etal. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322:271-275.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 51
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ etal. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 2010; 184:3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3
  • 53
    • 84856567623 scopus 로고    scopus 로고
    • Expression of Helios in peripherally induced Foxp3+ regulatory T cells
    • Gottschalk RA, Corse E, Allison JP. Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol 2012; 188:976-980.
    • (2012) J Immunol , vol.188 , pp. 976-980
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 54
    • 82655184651 scopus 로고    scopus 로고
    • The PDL1-PD1 axis converts human TH1 cells into regulatory T cells
    • Amarnath S, Mangus CW, Wang JC etal. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med 2011; 3:111ra20.
    • (2011) Sci Transl Med , vol.3
    • Amarnath, S.1    Mangus, C.W.2    Wang, J.C.3
  • 55
    • 84879124355 scopus 로고    scopus 로고
    • Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation
    • Tatara R, Ozaki K, Kikuchi Y etal. Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation. Cytotherapy 2011; 13:686-694.
    • (2011) Cytotherapy , vol.13 , pp. 686-694
    • Tatara, R.1    Ozaki, K.2    Kikuchi, Y.3
  • 56
    • 77956215701 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    • Ghannam S, Pene J, Torcy-Moquet G, Jorgensen C, Yssel H. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 2010; 185:302-312.
    • (2010) J Immunol , vol.185 , pp. 302-312
    • Ghannam, S.1    Pene, J.2    Torcy-Moquet, G.3    Jorgensen, C.4    Yssel, H.5
  • 57
    • 84858977073 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis
    • Tasso R, Ilengo C, Quarto R, Cancedda R, Caspi RR, Pennesi G. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 2012; 53:786-793.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 786-793
    • Tasso, R.1    Ilengo, C.2    Quarto, R.3    Cancedda, R.4    Caspi, R.R.5    Pennesi, G.6
  • 58
    • 79955971620 scopus 로고    scopus 로고
    • The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells
    • Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, Le Blanc K. The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 2011; 117:4826-4835.
    • (2011) Blood , vol.117 , pp. 4826-4835
    • Mougiakakos, D.1    Jitschin, R.2    Johansson, C.C.3    Okita, R.4    Kiessling, R.5    Le Blanc, K.6
  • 59
    • 79954559096 scopus 로고    scopus 로고
    • T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells
    • Cheng G, Yu A, Malek TR. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev 2011; 241:63-76.
    • (2011) Immunol Rev , vol.241 , pp. 63-76
    • Cheng, G.1    Yu, A.2    Malek, T.R.3
  • 60
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009; 10:595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 61
    • 34548604258 scopus 로고    scopus 로고
    • Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells
    • Haniffa MA, Wang XN, Holtick U etal. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 2007; 179:1595-1604.
    • (2007) J Immunol , vol.179 , pp. 1595-1604
    • Haniffa, M.A.1    Wang, X.N.2    Holtick, U.3
  • 62
    • 38449121250 scopus 로고    scopus 로고
    • The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells
    • Jones S, Horwood N, Cope A, Dazzi F. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J Immunol 2007; 179:2824-2831.
    • (2007) J Immunol , vol.179 , pp. 2824-2831
    • Jones, S.1    Horwood, N.2    Cope, A.3    Dazzi, F.4
  • 63
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B etal. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 64
    • 79960369940 scopus 로고    scopus 로고
    • Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
    • Daniel C, Weigmann B, Bronson R, von Boehmer H. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 2011; 208:1501-1510.
    • (2011) J Exp Med , vol.208 , pp. 1501-1510
    • Daniel, C.1    Weigmann, B.2    Bronson, R.3    von Boehmer, H.4
  • 65
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm AP, Carpentier PA, Anger HA, Miller SD. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002; 169:4712-4716.
    • (2002) J Immunol , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 66
    • 33947667952 scopus 로고    scopus 로고
    • GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
    • Bushell A, Wood K. GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007; 7:759-768.
    • (2007) Am J Transplant , vol.7 , pp. 759-768
    • Bushell, A.1    Wood, K.2
  • 67
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig SN, Wieckiewicz J, Wu DC etal. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010; 16:809-813.
    • (2010) Nat Med , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3
  • 68
    • 78650835204 scopus 로고    scopus 로고
    • Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    • Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, Wood K. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010; 90:1321-1327.
    • (2010) Transplantation , vol.90 , pp. 1321-1327
    • Issa, F.1    Hester, J.2    Goto, R.3    Nadig, S.N.4    Goodacre, T.E.5    Wood, K.6
  • 69
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann J, Hoffmann P, Edinger M etal. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 2005; 105:2220-2226.
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3
  • 70
    • 80052157997 scopus 로고    scopus 로고
    • Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells
    • Shin HJ, Baker J, Leveson-Gower DB, Smith AT, Sega EI, Negrin RS. Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells. Blood 2011; 118:2342-2350.
    • (2011) Blood , vol.118 , pp. 2342-2350
    • Shin, H.J.1    Baker, J.2    Leveson-Gower, D.B.3    Smith, A.T.4    Sega, E.I.5    Negrin, R.S.6
  • 71
    • 70249122695 scopus 로고    scopus 로고
    • First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
    • Trzonkowski P, Bieniaszewska M, Juscinska J etal. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin Immunol 2009; 133:22-26.
    • (2009) Clin Immunol , vol.133 , pp. 22-26
    • Trzonkowski, P.1    Bieniaszewska, M.2    Juscinska, J.3
  • 72
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q etal. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 117:1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 73
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A etal. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011; 117:3921-3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 74
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • Koreth J, Matsuoka K, Kim HT etal. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 2011; 365:2055-2066.
    • (2011) N Engl J Med , vol.365 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 75
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005; 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 76
    • 77949886577 scopus 로고    scopus 로고
    • Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease
    • Sewgobind VD, van der Laan LJ, Kho MM etal. Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease. Transplantation 2010; 89:655-666.
    • (2010) Transplantation , vol.89 , pp. 655-666
    • Sewgobind, V.D.1    van der Laan, L.J.2    Kho, M.M.3


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