Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells

Experimental Hematology

Volumn 33, Issue 8, 2005, Pages 928-934

  Groh, Margaret E ^a   Maitra, Basabi ^a   Szekely, Emese ^a   Koç, Omer N ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA;

ARTICLE; BONE MARROW; CELL ACTIVATION; CELL COMMUNICATION; CELL CONTACT; CELL CULTURE; CELL INTERACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREGULATION; MESENCHYMAL STEM CELL; MESENCHYME CELL; MICROENVIRONMENT; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; MESENCHYMAL STEM CELLS; MONOCYTES; T-LYMPHOCYTE SUBSETS;

EID: 22144473736     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2005.05.002     Document Type: Article

References (17)

1. M. Pittenger, A. Mackay, and S. Beck Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
2. M. Di Nicola, C. Carlo-Stella, and M. Magni Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli Blood 99 2002 3838 3843
3. W.T. Tse, J.D. Pendleton, W.M. Beyer, M.C. Egalka, and E.C. Guinan Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 75 2003 389 397
4. M. Krampera, S. Glennie, and J. Dyson Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide Blood 101 2003 3722 3729 Epub 2002 Dec 27
5. K. Le Blanc, C. Tammik, K. Rosendahl, E. Zetterberg, and O. Ringden HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells Exp Hematol 31 2003 890 896
6. B. Maitra, E. Szekely, and K. Gjini Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation Bone Marrow Transplant 33 2004 597 604
7. S. Aggarwal, and M. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822 Epub 2004 Oct 19
8. S. Beyth, Z. Borovsky, and D. Mevorach Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T cell unresponsiveness Blood 105 2005 2214 2219 Epub 2004 Oct 28
9. R. Meisel, A. Zibert, M. Laryea, U. Gobel, W. Daubener, and D. Dilloo Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation Blood 103 2004 4619 4621 Epub 2004 Mar 4
10. O.N. Koç, and H.M. Lazarus Mesenchymal stem cells: heading into the clinic Bone Marrow Transplant 27 2001 235 239
11. K. Le Blanc, I. Rasmusson, and B. Sundberg Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 9419 2004 1439 1441
12. A. Bacigalupo, M. Valle, and M. Podesta The suppressive effect of bone marrow mesenchymal stem cells on T cell activation is deficient in patients with severe aplastic anemia Blood 104 2004 147a
13. F. Djouad, P. Plence, and C. Bony Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals Blood 102 2003 3837 3844 Epub 2003 Jul 24
14. K. Le Blanc, I. Rasmusson, and C. Gotherstrom Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes Scand J Immunol 60 2004 307 315
15. A. Bartholomew, C. Sturgeon, and M. Siatskas Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Exp Hematol 30 2002 42 48
16. O.N. Koç, S.L. Gerson, and B.W. Cooper Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy J Clin Oncol 18 2000 307 316
17. O.N. Koç, J. Day, M. Nieder, S.L. Gerson, H.M. Lazarus, and W. Krivit Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) Bone Marrow Transplant 30 2002 215 222