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Volumn 28, Issue 4, 2013, Pages 611-616

Ghrelin and leptin pathophysiology in chronic kidney disease

Author keywords

Cachexia; Cardiovascular; Chronic kidney disease; Ghrelin; Inflammation; Leptin; Mortality

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GHRELIN; GHRELIN RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; OBESTATIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84879994859     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-012-2380-9     Document Type: Review
Times cited : (35)

References (55)
  • 1
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • 16284174 10.1126/science.1117255 1:CAS:528:DC%2BD2MXhtF2is7bM
    • Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310(5750):996-999
    • (2005) Science , vol.310 , Issue.5750 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5    Klein, C.6    Hsueh, A.J.7
  • 2
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • 11057670 10.1038/35038090
    • Tschöp M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407(6806):908-913
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 4
    • 2942558193 scopus 로고    scopus 로고
    • Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
    • 15039149 10.1152/ajpendo.00582.2003 1:CAS:528:DC%2BD2cXmvVKntLo%3D
    • Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 287:E297-E304
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Cummings, D.E.1    Frayo, R.S.2    Marmonier, C.3    Aubert, R.4    Chapelot, D.5
  • 6
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • 15180951 10.1210/er.2002-0029
    • Van der Lely AJ, Tschöp M, Heiman ML, Ghigo E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25(3):426-457
    • (2004) Endocr Rev , vol.25 , Issue.3 , pp. 426-457
    • Van Der Lely, A.J.1    Tschöp, M.2    Heiman, M.L.3    Ghigo, E.4
  • 7
    • 0242383502 scopus 로고    scopus 로고
    • Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart
    • 14556085 10.1007/s00395-003-0434-7 1:CAS:528:DC%2BD3sXpsl2qtrk%3D
    • Frascarelli S, Ghelardoni S, Ronca-Testoni S, Zucchi R (2003) Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic Res Cardiol 98(6):401-405
    • (2003) Basic Res Cardiol , vol.98 , Issue.6 , pp. 401-405
    • Frascarelli, S.1    Ghelardoni, S.2    Ronca-Testoni, S.3    Zucchi, R.4
  • 8
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • 11560861 10.1161/hc3601.095575 1:CAS:528:DC%2BD3MXnslCltbw%3D
    • Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, Shimizu W, Hosoda H, Hirota Y, Ishida H, Mori H, Kangawa K (2001) Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104(12):1430-1435
    • (2001) Circulation , vol.104 , Issue.12 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Ikeda, Y.4    Yoshihara, F.5    Shimizu, W.6    Hosoda, H.7    Hirota, Y.8    Ishida, H.9    Mori, H.10    Kangawa, K.11
  • 10
    • 0035712816 scopus 로고    scopus 로고
    • The NPY/AgRP neuron and energy homeostasis
    • 10.1038/sj.ijo.0801915 1:CAS:528:DC%2BD38XitVCmtbc%3D
    • Morton GJ, Schwartz MW (2001) The NPY/AgRP neuron and energy homeostasis. Int J Obesity Relat Metab Disord 25(Suppl 5):S56-S62
    • (2001) Int J Obesity Relat Metab Disord , vol.25 , Issue.SUPPL. 5
    • Morton, G.J.1    Schwartz, M.W.2
  • 11
    • 79960955701 scopus 로고    scopus 로고
    • Evolution of leptin structure and function
    • 21677426 10.1159/000328435 1:CAS:528:DC%2BC3MXptlertbs%3D
    • Denver RJ, Bonett RM, Boorse GC (2011) Evolution of leptin structure and function. Neuroendocrinology 94(1):21-38
    • (2011) Neuroendocrinology , vol.94 , Issue.1 , pp. 21-38
    • Denver, R.J.1    Bonett, R.M.2    Boorse, G.C.3
  • 12
    • 33644863943 scopus 로고    scopus 로고
    • Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling
    • 10.1002/ajmg.a.31099 1:CAS:528:DC%2BD2sXms1SqsLc%3D
    • Cohen MM (2006) Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling. Am J Med Genet A 140A:515-524
    • (2006) Am J Med Genet A , vol.140 , pp. 515-524
    • Cohen, M.M.1
  • 13
    • 0029949063 scopus 로고    scopus 로고
    • Leptin activation in hypothalamus
    • 8657278 10.1038/381745a0 1:CAS:528:DyaK28XjvVKgurw%3D
    • Woods AJ, Stock MJ (1996) Leptin activation in hypothalamus. Nature 381:745
    • (1996) Nature , vol.381 , pp. 745
    • Woods, A.J.1    Stock, M.J.2
  • 14
    • 0035081809 scopus 로고    scopus 로고
    • Melanocortin receptors: Their functions and regulation by physiological agonists and antagonists
    • 11315190 10.1007/PL00000868 1:CAS:528:DC%2BD3MXjtVahtL0%3D
    • Abdel-Malek ZA (2001) Melanocortin receptors: their functions and regulation by physiological agonists and antagonists. Cell Mol Life Sci 58:434-441
    • (2001) Cell Mol Life Sci , vol.58 , pp. 434-441
    • Abdel-Malek, Z.A.1
  • 16
    • 0035973147 scopus 로고    scopus 로고
    • Potential role of leptin in angiogenesis: Leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro
    • 11460888 10.1038/emm.2001.17 1:CAS:528:DC%2BD3MXls1arurk%3D
    • Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33(2):95-102
    • (2001) Exp Mol Med , vol.33 , Issue.2 , pp. 95-102
    • Park, H.Y.1    Kwon, H.M.2    Lim, H.J.3    Hong, B.K.4    Lee, J.Y.5    Park, B.E.6    Jang, Y.7    Cho, S.Y.8    Kim, H.S.9
  • 19
    • 44449087465 scopus 로고    scopus 로고
    • Leptin and the sympathetic connection of fat to bone
    • 17924050 10.1007/s00198-007-0487-9 1:CAS:528:DC%2BD1cXmsFKnuro%3D
    • Hamrick MW, Ferrari SL (2008) Leptin and the sympathetic connection of fat to bone. Osteoporos Int 19(7):905-912
    • (2008) Osteoporos Int , vol.19 , Issue.7 , pp. 905-912
    • Hamrick, M.W.1    Ferrari, S.L.2
  • 21
    • 0842308729 scopus 로고    scopus 로고
    • Unraveling the multiple roles of leptin in inflammation and autoimmunity
    • 10.1007/s00109-003-0492-1
    • La Cava A, Alviggi C, Matarese G (2004) Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med (Berl) 82(1):4-11
    • (2004) J Mol Med (Berl) , vol.82 , Issue.1 , pp. 4-11
    • La Cava, A.1    Alviggi, C.2    Matarese, G.3
  • 22
    • 84855176875 scopus 로고    scopus 로고
    • Ghrelin and muscle metabolism in chronic uremia
    • 22200437 10.1053/j.jrn.2011.10.017 1:CAS:528:DC%2BC38XpvFyk
    • Barazzoni R, Gortan Cappellari G, Zanetti M, Guarnieri G (2012) Ghrelin and muscle metabolism in chronic uremia. J Ren Nutr 22(1):171-175
    • (2012) J Ren Nutr , vol.22 , Issue.1 , pp. 171-175
    • Barazzoni, R.1    Gortan Cappellari, G.2    Zanetti, M.3    Guarnieri, G.4
  • 26
    • 77957267841 scopus 로고    scopus 로고
    • Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease
    • 20607302 10.1007/s00467-010-1588-9
    • Büscher AK, Büscher R, Hauffa BP, Hoyer PF (2010) Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease. Pediatr Nephrol 25(11):2295-2301
    • (2010) Pediatr Nephrol , vol.25 , Issue.11 , pp. 2295-2301
    • Büscher, A.K.1    Büscher, R.2    Hauffa, B.P.3    Hoyer, P.F.4
  • 27
    • 78449281408 scopus 로고    scopus 로고
    • Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease
    • 20734087 10.1007/s00467-010-1628-5
    • Naufel MF, Bordon M, de Aquino TM, Ribeiro EB, de Abreu Carvalhaes JT (2010) Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease. Pediatr Nephrol 25(12):2477-2482
    • (2010) Pediatr Nephrol , vol.25 , Issue.12 , pp. 2477-2482
    • Naufel, M.F.1    Bordon, M.2    De Aquino, T.M.3    Ribeiro, E.B.4    De Abreu Carvalhaes, J.T.5
  • 28
    • 78650787867 scopus 로고    scopus 로고
    • Hormonal regulation of energy-protein homeostasis in hemodialysis patients: An anorexigenic profile that may predispose to adverse cardiovascular outcomes
    • 20959536 10.1152/ajpendo.00438.2010 1:CAS:528:DC%2BC3MXhvVSjs7Y%3D
    • Suneja M, Murry DJ, Stokes JB, Lim VS (2011) Hormonal regulation of energy-protein homeostasis in hemodialysis patients: an anorexigenic profile that may predispose to adverse cardiovascular outcomes. Am J Physiol Endocrinol Metab 300(1):E55-E64
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , Issue.1
    • Suneja, M.1    Murry, D.J.2    Stokes, J.B.3    Lim, V.S.4
  • 29
    • 0030927377 scopus 로고    scopus 로고
    • Leptin is cleared from the circulation primarily by the kidney
    • 9192234 10.1038/sj.ijo.0800428 1:CAS:528:DyaK2sXksVWqs74%3D
    • Cumin F, Baum HP, De Gasparo M, Levens N (1997) Leptin is cleared from the circulation primarily by the kidney. Int J obes Relat Metab Disord 21:495-504
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 495-504
    • Cumin, F.1    Baum, H.P.2    De Gasparo, M.3    Levens, N.4
  • 30
    • 84866146537 scopus 로고    scopus 로고
    • Relationship between plasma leptin level and chronic kidney disease
    • doi: 10.1155/2012/269532
    • Shankar A, Syamala S, Xiao J, Muntner P (2012) Relationship between plasma leptin level and chronic kidney disease. Int J Nephrol. 2012: 269532. doi: 10.1155/2012/269532
    • (2012) Int J Nephrol. , pp. 269532
    • Shankar, A.1    Syamala, S.2    Xiao, J.3    Muntner, P.4
  • 31
    • 79952689406 scopus 로고    scopus 로고
    • Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients
    • 21178976 10.1038/ki.2010.487 1:CAS:528:DC%2BC3MXjtFGjtbs%3D
    • Carrero JJ, Nakashima A, Qureshi AR, Lindholm B, Heimbürger O, Bárány P, Stenvinkel P (2011) Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients. Kidney Int 79(7):749-756
    • (2011) Kidney Int , vol.79 , Issue.7 , pp. 749-756
    • Carrero, J.J.1    Nakashima, A.2    Qureshi, A.R.3    Lindholm, B.4    Heimbürger, O.5    Bárány, P.6    Stenvinkel, P.7
  • 34
    • 20444497662 scopus 로고    scopus 로고
    • Role of leptin and melanocortin signaling in uremia-associated cachexia
    • 15931394 10.1172/JCI22521 1:CAS:528:DC%2BD2MXkvF2lsrc%3D
    • Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH (2005) Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115(6):1659-1665
    • (2005) J Clin Invest , vol.115 , Issue.6 , pp. 1659-1665
    • Cheung, W.1    Yu, P.X.2    Little, B.M.3    Cone, R.D.4    Marks, D.L.5    Mak, R.H.6
  • 35
    • 38849187108 scopus 로고    scopus 로고
    • Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients
    • 17854954 10.1016/j.clnu.2007.06.013 1:CAS:528:DC%2BD1cXhslOltrg%3D
    • Barazzoni R, Zanetti M, Stulle M, Mucci MP, Pirulli A, Dore F, Panzetta G, Vasile A, Biolo G, Guarnieri G (2008) Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients. Clin Nutr 27:142-149
    • (2008) Clin Nutr , vol.27 , pp. 142-149
    • Barazzoni, R.1    Zanetti, M.2    Stulle, M.3    Mucci, M.P.4    Pirulli, A.5    Dore, F.6    Panzetta, G.7    Vasile, A.8    Biolo, G.9    Guarnieri, G.10
  • 37
    • 0344588820 scopus 로고    scopus 로고
    • Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood
    • 9621291 1:CAS:528:DyaK1cXjvFWisLg%3D
    • Daschner M, Tönshoff B, Blum WF, Englaro P, Wingen AM, Schaefer F, Wühl E, Rascher W, Mehls O (1998) Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Am Soc Nephrol 9(6):1074-1079
    • (1998) J Am Soc Nephrol , vol.9 , Issue.6 , pp. 1074-1079
    • Daschner, M.1    Tönshoff, B.2    Blum, W.F.3    Englaro, P.4    Wingen, A.M.5    Schaefer, F.6    Wühl, E.7    Rascher, W.8    Mehls, O.9
  • 38
    • 0346270554 scopus 로고    scopus 로고
    • Relationship of leptin and insulin-like growth factor i to nutritional status in hemodialyzed children
    • 14586683 10.1007/s00467-003-1264-4
    • Besbas N, Ozaltin F, Coşkun T, Ozalp S, Saatçi U, Bakkaloǧlu A, El Nahas AM (2003) Relationship of leptin and insulin-like growth factor I to nutritional status in hemodialyzed children. Pediatr Nephrol 18(12):1255-1259
    • (2003) Pediatr Nephrol , vol.18 , Issue.12 , pp. 1255-1259
    • Besbas, N.1    Ozaltin, F.2    Coşkun, T.3    Ozalp, S.4    Saatçi, U.5    Bakkaloǧlu, A.6    El Nahas, A.M.7
  • 39
    • 0034042923 scopus 로고    scopus 로고
    • Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass
    • 10864587 1:CAS:528:DC%2BD3cXltFOjurk%3D
    • Stenvinkel P, Lindholm B, Lönnqvist F, Katzarski K, Heimbürger O (2000) Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 11:1303-1309
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1303-1309
    • Stenvinkel, P.1    Lindholm, B.2    Lönnqvist, F.3    Katzarski, K.4    Heimbürger, O.5
  • 41
    • 27744582252 scopus 로고    scopus 로고
    • Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: A randomized, placebo-controlled trial
    • 15888560 10.1681/ASN.2005010039 1:CAS:528:DC%2BD2MXms1egs7k%3D
    • Wynne K, Giannitsopoulou K, Small CJ, Patterson M, Frost G, Ghatei MA, Brown EA, Bloom SR, Choi P (2005) Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial. J Am Soc Nephrol 16:2111-2118
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2111-2118
    • Wynne, K.1    Giannitsopoulou, K.2    Small, C.J.3    Patterson, M.4    Frost, G.5    Ghatei, M.A.6    Brown, E.A.7    Bloom, S.R.8    Choi, P.9
  • 43
    • 33644554532 scopus 로고    scopus 로고
    • Leptin and inflammation-associated cachexia in chronic kidney disease
    • 16518340 10.1038/sj.ki.5000182 1:CAS:528:DC%2BD28Xhs1Kitrc%3D
    • Mak RH, Cheung W, Cone RD, Marks DL (2006) Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69(5):794-797
    • (2006) Kidney Int , vol.69 , Issue.5 , pp. 794-797
    • Mak, R.H.1    Cheung, W.2    Cone, R.D.3    Marks, D.L.4
  • 44
    • 13844270518 scopus 로고    scopus 로고
    • Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats
    • 15507538 10.1152/ajpendo.00196.2004 1:CAS:528:DC%2BD2MXisVKqsrg%3D
    • Granado M, Priego T, Martin AI, Villanua MA, Lopez-Calderon A (2005) Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab 288:E486-E492
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Granado, M.1    Priego, T.2    Martin, A.I.3    Villanua, M.A.4    Lopez-Calderon, A.5
  • 46
    • 0029863684 scopus 로고    scopus 로고
    • Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
    • 8621806 10.1172/JCI118653 1:CAS:528:DyaK28Xislymsb0%3D
    • Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold KR (1996) Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 97:2152-2157
    • (1996) J Clin Invest , vol.97 , pp. 2152-2157
    • Grunfeld, C.1    Zhao, C.2    Fuller, J.3    Pollack, A.4    Moser, A.5    Friedman, J.6    Feingold, K.R.7
  • 49
    • 84859831465 scopus 로고    scopus 로고
    • Cardiovascular disease in children with chronic kidney disease
    • 22383696 10.1681/ASN.2011111115 1:CAS:528:DC%2BC38XlvFOisL4%3D
    • Mitsnefes MM (2012) Cardiovascular disease in children with chronic kidney disease. J Am Soc Nephrol 23(4):578-585
    • (2012) J Am Soc Nephrol , vol.23 , Issue.4 , pp. 578-585
    • Mitsnefes, M.M.1
  • 50
    • 0035100787 scopus 로고    scopus 로고
    • Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
    • 11244021 10.1161/01.HYP.37.3.936 1:CAS:528:DC%2BD3MXitFems78%3D
    • Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG (2001) Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension 37(3):936-942
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 936-942
    • Correia, M.L.1    Morgan, D.A.2    Sivitz, W.I.3    Mark, A.L.4    Haynes, W.G.5
  • 51
    • 1642546991 scopus 로고    scopus 로고
    • Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension
    • 15051422 10.1016/j.lfs.2003.10.029 1:CAS:528:DC%2BD2cXisF2msLk%3D
    • Beltowski J, Wójcicka G, Marciniak A, Jamroz A (2004) Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension. Life Sci 74(24):2987-3000
    • (2004) Life Sci , vol.74 , Issue.24 , pp. 2987-3000
    • Beltowski, J.1    Wójcicka, G.2    Marciniak, A.3    Jamroz, A.4
  • 52
    • 77958103211 scopus 로고    scopus 로고
    • Low serum acylated ghrelin levels are associated with the development of cardiovascular disease in hemodialysis patients
    • 20930430 10.2169/internalmedicine.49.3047 1:CAS:528:DC%2BC38XhsVOmurbK
    • Chou CC, Bai CH, Tsai SC, Wu MS (2010) Low serum acylated ghrelin levels are associated with the development of cardiovascular disease in hemodialysis patients. Intern Med 49(19):2057-2064
    • (2010) Intern Med , vol.49 , Issue.19 , pp. 2057-2064
    • Chou, C.C.1    Bai, C.H.2    Tsai, S.C.3    Wu, M.S.4
  • 53
    • 0036420550 scopus 로고    scopus 로고
    • Leptin correlates with some hemostatic parameters in CAPD patients
    • 12372966 10.1159/000064074
    • Małyszko J, Wołczyński S, Małyszko J, MyÅliwiec M (2002) Leptin correlates with some hemostatic parameters in CAPD patients. Nephron 92(3):721-724
    • (2002) Nephron , vol.92 , Issue.3 , pp. 721-724
    • Małyszko, J.1    Wołczyński, S.2    Małyszko, J.3    Myåliwiec, M.4
  • 54
    • 0030699352 scopus 로고    scopus 로고
    • High plasma immunoreactive leptin level in essential hypertension
    • 9370390 10.1016/S0895-7061(97)00310-5 1:STN:280:DyaK1c%2Fjs1WmtQ%3D%3D
    • Agata J, Masuda A, Takada M, Higashiura K, Murakami H, Miyazaki Y, Shimamoto K (1997) High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 10(10 Pt 1):1171-1174
    • (1997) Am J Hypertens , vol.10 , Issue.10 PART 1 , pp. 1171-1174
    • Agata, J.1    Masuda, A.2    Takada, M.3    Higashiura, K.4    Murakami, H.5    Miyazaki, Y.6    Shimamoto, K.7
  • 55
    • 79952650364 scopus 로고    scopus 로고
    • Is ghrelin a biomarker for mortality in end-stage renal disease?
    • 21403653 10.1038/ki.2010.520 1:CAS:528:DC%2BC3MXjtFGjtLc%3D
    • Mak RH, Cheung WW (2011) Is ghrelin a biomarker for mortality in end-stage renal disease? Kidney Int 79(7):697-699
    • (2011) Kidney Int , vol.79 , Issue.7 , pp. 697-699
    • Mak, R.H.1    Cheung, W.W.2


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