메뉴 건너뛰기




Volumn 34, Issue 10, 2013, Pages 2431-2440

Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation

Author keywords

Adulthood; Aging; Alzheimer's disease; Amyloid precursor protein; Cognition; Learning and memory; Neurogenesis

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

EID: 84879885442     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.04.016     Document Type: Article
Times cited : (60)

References (61)
  • 1
    • 65549125564 scopus 로고    scopus 로고
    • Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain
    • Ahlenius H., Visan V., Kokaia M., Lindvall O., Kokaia Z. Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J.Neurosci. 2009, 29:4408-4419.
    • (2009) J.Neurosci. , vol.29 , pp. 4408-4419
    • Ahlenius, H.1    Visan, V.2    Kokaia, M.3    Lindvall, O.4    Kokaia, Z.5
  • 3
    • 84862697779 scopus 로고    scopus 로고
    • Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells
    • Baratchi S., Evans J., Tate W.P., Abraham W.C., Connor B. Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus 2012, 22:1517-1527.
    • (2012) Hippocampus , vol.22 , pp. 1517-1527
    • Baratchi, S.1    Evans, J.2    Tate, W.P.3    Abraham, W.C.4    Connor, B.5
  • 4
    • 78650669822 scopus 로고    scopus 로고
    • The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway
    • Belyaev N.D., Kellett K.A., Beckett C., Makova N.Z., Revett T.J., Nalivaeva N.N., Hooper N.M., Turner A.J. The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J.Biol. Chem. 2010, 285:41443-41454.
    • (2010) J.Biol. Chem. , vol.285 , pp. 41443-41454
    • Belyaev, N.D.1    Kellett, K.A.2    Beckett, C.3    Makova, N.Z.4    Revett, T.J.5    Nalivaeva, N.N.6    Hooper, N.M.7    Turner, A.J.8
  • 6
    • 13844271818 scopus 로고    scopus 로고
    • Neural stem cells as therapeutic agents for age-related brain repair
    • Bernal G.M., Peterson D.A. Neural stem cells as therapeutic agents for age-related brain repair. Aging Cell 2004, 3:345-351.
    • (2004) Aging Cell , vol.3 , pp. 345-351
    • Bernal, G.M.1    Peterson, D.A.2
  • 7
    • 13844257516 scopus 로고    scopus 로고
    • Neurogenesis in a rat model of age-related cognitive decline
    • Bizon J.L., Lee H.J., Gallagher M. Neurogenesis in a rat model of age-related cognitive decline. Aging Cell 2004, 3:227-234.
    • (2004) Aging Cell , vol.3 , pp. 227-234
    • Bizon, J.L.1    Lee, H.J.2    Gallagher, M.3
  • 9
    • 1242271233 scopus 로고    scopus 로고
    • Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice
    • Bondolfi L., Ermini F., Long J.M., Ingram D.K., Jucker M. Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol. Aging 2004, 25:333-340.
    • (2004) Neurobiol. Aging , vol.25 , pp. 333-340
    • Bondolfi, L.1    Ermini, F.2    Long, J.M.3    Ingram, D.K.4    Jucker, M.5
  • 10
    • 78650679757 scopus 로고    scopus 로고
    • Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood
    • Bouab M., Paliouras G.N., Aumont A., Forest-Berard K., Fernandes K.J. Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood. Neuroscience 2011, 173:135-149.
    • (2011) Neuroscience , vol.173 , pp. 135-149
    • Bouab, M.1    Paliouras, G.N.2    Aumont, A.3    Forest-Berard, K.4    Fernandes, K.J.5
  • 12
    • 2542519087 scopus 로고    scopus 로고
    • Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
    • Caille I., Allinquant B., Dupont E., Bouillot C., Langer A., Muller U., Prochiantz A. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 2004, 131:2173-2181.
    • (2004) Development , vol.131 , pp. 2173-2181
    • Caille, I.1    Allinquant, B.2    Dupont, E.3    Bouillot, C.4    Langer, A.5    Muller, U.6    Prochiantz, A.7
  • 13
    • 0033306418 scopus 로고    scopus 로고
    • Restoring production of hippocampal neurons in old age
    • Cameron H.A., McKay R.D. Restoring production of hippocampal neurons in old age. Nat. Neurosci. 1999, 2:894-897.
    • (1999) Nat. Neurosci. , vol.2 , pp. 894-897
    • Cameron, H.A.1    McKay, R.D.2
  • 14
    • 79551546647 scopus 로고    scopus 로고
    • Secreted amyloid precursor protein beta and secreted amyloid precursor protein α induce axon outgrowth invitro through Egr1 signaling pathway
    • Chasseigneaux S., Dinc L., Rose C., Chabret C., Coulpier F., Topilko P., Mauger G., Allinquant B. Secreted amyloid precursor protein beta and secreted amyloid precursor protein α induce axon outgrowth invitro through Egr1 signaling pathway. PLoS One 2011, 6:e16301.
    • (2011) PLoS One , vol.6
    • Chasseigneaux, S.1    Dinc, L.2    Rose, C.3    Chabret, C.4    Coulpier, F.5    Topilko, P.6    Mauger, G.7    Allinquant, B.8
  • 15
    • 77953505738 scopus 로고    scopus 로고
    • Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice
    • Demars M., Hu Y.S., Gadadhar A., Lazarov O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J.Neurosci. Res. 2010, 88:2103-2117.
    • (2010) J.Neurosci. Res. , vol.88 , pp. 2103-2117
    • Demars, M.1    Hu, Y.S.2    Gadadhar, A.3    Lazarov, O.4
  • 16
    • 80053918665 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
    • Demars M.P., Bartholomew A., Strakova Z., Lazarov O. Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res. Ther. 2011, 2:36.
    • (2011) Stem Cell Res. Ther. , vol.2 , pp. 36
    • Demars, M.P.1    Bartholomew, A.2    Strakova, Z.3    Lazarov, O.4
  • 19
    • 4644294031 scopus 로고    scopus 로고
    • Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination
    • Enwere E., Shingo T., Gregg C., Fujikawa H., Ohta S., Weiss S. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J.Neurosci. 2004, 24:8354-8365.
    • (2004) J.Neurosci. , vol.24 , pp. 8354-8365
    • Enwere, E.1    Shingo, T.2    Gregg, C.3    Fujikawa, H.4    Ohta, S.5    Weiss, S.6
  • 20
    • 0003698235 scopus 로고    scopus 로고
    • The mouse brain in stereotaxic coordinates
    • Elsevier Academic Press, San Diego
    • Franklin, K., Paxinos, G., 2008. The mouse brain in stereotaxic coordinates, third ed. Elsevier Academic Press, San Diego.
    • (2008) third ed.
    • Franklin, K.1    Paxinos, G.2
  • 21
    • 0029841562 scopus 로고    scopus 로고
    • Increased activity-regulating and neuroprotective efficacy of α-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain
    • Furukawa K., Sopher B.L., Rydel R.E., Begley J.G., Pham D.G., Martin G.M., Fox M., Mattson M.P. Increased activity-regulating and neuroprotective efficacy of α-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J.Neurochem. 1996, 67:1882-1896.
    • (1996) J.Neurochem. , vol.67 , pp. 1882-1896
    • Furukawa, K.1    Sopher, B.L.2    Rydel, R.E.3    Begley, J.G.4    Pham, D.G.5    Martin, G.M.6    Fox, M.7    Mattson, M.P.8
  • 22
    • 77955637621 scopus 로고    scopus 로고
    • APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation
    • Ghosal K., Stathopoulos A., Pimplikar S.W. APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS One 2010, 5:e11866.
    • (2010) PLoS One , vol.5
    • Ghosal, K.1    Stathopoulos, A.2    Pimplikar, S.W.3
  • 23
    • 70350370474 scopus 로고    scopus 로고
    • Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    • Goodger Z.V., Rajendran L., Trutzel A., Kohli B.M., Nitsch R.M., Konietzko U. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J.Cell. Sci. 2009, 122:3703-3714.
    • (2009) J.Cell. Sci. , vol.122 , pp. 3703-3714
    • Goodger, Z.V.1    Rajendran, L.2    Trutzel, A.3    Kohli, B.M.4    Nitsch, R.M.5    Konietzko, U.6
  • 24
    • 36048947606 scopus 로고    scopus 로고
    • Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    • Hattiangady B., Shetty A.K. Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol. Aging 2008, 29:129-147.
    • (2008) Neurobiol. Aging , vol.29 , pp. 129-147
    • Hattiangady, B.1    Shetty, A.K.2
  • 25
    • 1242316182 scopus 로고    scopus 로고
    • Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation
    • Heine V.M., Maslam S., Joels M., Lucassen P.J. Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiol. Aging 2004, 25:361-375.
    • (2004) Neurobiol. Aging , vol.25 , pp. 361-375
    • Heine, V.M.1    Maslam, S.2    Joels, M.3    Lucassen, P.J.4
  • 28
    • 0033654329 scopus 로고    scopus 로고
    • Neurogenesis in the adult hippocampus
    • discussion 235-241, 302-226
    • Kempermann G., Gage F.H. Neurogenesis in the adult hippocampus. Novartis Found. Symp. 2000, 231:220-235. discussion 235-241, 302-226.
    • (2000) Novartis Found. Symp. , vol.231 , pp. 220-235
    • Kempermann, G.1    Gage, F.H.2
  • 29
    • 0036325981 scopus 로고    scopus 로고
    • Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    • Kempermann G., Gast D., Gage F.H. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 2002, 52:135-143.
    • (2002) Ann. Neurol. , vol.52 , pp. 135-143
    • Kempermann, G.1    Gast, D.2    Gage, F.H.3
  • 30
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann G., Kuhn H.G., Gage F.H. Experience-induced neurogenesis in the senescent dentate gyrus. J.Neurosci. 1998, 18:3206-3212.
    • (1998) J.Neurosci. , vol.18 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 31
    • 33646383889 scopus 로고    scopus 로고
    • Down-regulation of endogenous amyloid precursor protein processing due to cellular aging
    • Kern A., Roempp B., Prager K., Walter J., Behl C. Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. J.Biol. Chem. 2006, 281:2405-2413.
    • (2006) J.Biol. Chem. , vol.281 , pp. 2405-2413
    • Kern, A.1    Roempp, B.2    Prager, K.3    Walter, J.4    Behl, C.5
  • 33
    • 4043072841 scopus 로고    scopus 로고
    • Increased expression of amyloid precursor protein in oral squamous cell carcinoma
    • Ko S.Y., Lin S.C., Chang K.W., Wong Y.K., Liu C.J., Chi C.W., Liu T.Y. Increased expression of amyloid precursor protein in oral squamous cell carcinoma. Int. J. Cancer 2004, 111:727-732.
    • (2004) Int. J. Cancer , vol.111 , pp. 727-732
    • Ko, S.Y.1    Lin, S.C.2    Chang, K.W.3    Wong, Y.K.4    Liu, C.J.5    Chi, C.W.6    Liu, T.Y.7
  • 34
    • 33748188974 scopus 로고    scopus 로고
    • Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    • Kronenberg G., Bick-Sander A., Bunk E., Wolf C., Ehninger D., Kempermann G. Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol. Aging 2006, 27:1505-1513.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1505-1513
    • Kronenberg, G.1    Bick-Sander, A.2    Bunk, E.3    Wolf, C.4    Ehninger, D.5    Kempermann, G.6
  • 35
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J.Neurosci. 1996, 16:2027-2033.
    • (1996) J.Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 38
    • 78049267204 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    • Li H., Wang B., Wang Z., Guo Q., Tabuchi K., Hammer R.E., Sudhof T.C., Zheng H. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:17362-17367.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 17362-17367
    • Li, H.1    Wang, B.2    Wang, Z.3    Guo, Q.4    Tabuchi, K.5    Hammer, R.E.6    Sudhof, T.C.7    Zheng, H.8
  • 43
    • 50049104885 scopus 로고    scopus 로고
    • Newborn granule cells in the ageing dentate gyrus
    • Morgenstern N.A., Lombardi G., Schinder A.F. Newborn granule cells in the ageing dentate gyrus. J.Physiol. 2008, 586:3751-3757.
    • (2008) J.Physiol. , vol.586 , pp. 3751-3757
    • Morgenstern, N.A.1    Lombardi, G.2    Schinder, A.F.3
  • 44
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
    • (2009) Nature , vol.457 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 45
    • 0033012984 scopus 로고    scopus 로고
    • Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells
    • Ohsawa I., Takamura C., Morimoto T., Ishiguro M., Kohsaka S. Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur. J. Neurosci. 1999, 11:1907-1913.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 1907-1913
    • Ohsawa, I.1    Takamura, C.2    Morimoto, T.3    Ishiguro, M.4    Kohsaka, S.5
  • 46
    • 34247178605 scopus 로고    scopus 로고
    • Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle
    • Olariu A., Cleaver K.M., Cameron H.A. Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle. J.Comp. Neurol. 2007, 501:659-667.
    • (2007) J.Comp. Neurol. , vol.501 , pp. 659-667
    • Olariu, A.1    Cleaver, K.M.2    Cameron, H.A.3
  • 47
    • 0032539666 scopus 로고    scopus 로고
    • From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells
    • Pietrzik C.U., Hoffmann J., Stober K., Chen C.Y., Bauer C., Otero D.A., Roch J.M., Herzog V. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:1770-1775.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 1770-1775
    • Pietrzik, C.U.1    Hoffmann, J.2    Stober, K.3    Chen, C.Y.4    Bauer, C.5    Otero, D.A.6    Roch, J.M.7    Herzog, V.8
  • 48
    • 13444271905 scopus 로고    scopus 로고
    • Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation
    • Rao M.S., Hattiangady B., Abdel-Rahman A., Stanley D.P., Shetty A.K. Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation. Eur. J. Neurosci. 2005, 21:464-476.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 464-476
    • Rao, M.S.1    Hattiangady, B.2    Abdel-Rahman, A.3    Stanley, D.P.4    Shetty, A.K.5
  • 49
    • 0024395366 scopus 로고
    • Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts
    • Saitoh T., Sundsmo M., Roch J.M., Kimura N., Cole G., Schubert D., Oltersdorf T., Schenk D.B. Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 1989, 58:615-622.
    • (1989) Cell , vol.58 , pp. 615-622
    • Saitoh, T.1    Sundsmo, M.2    Roch, J.M.3    Kimura, N.4    Cole, G.5    Schubert, D.6    Oltersdorf, T.7    Schenk, D.B.8
  • 50
    • 40849097929 scopus 로고    scopus 로고
    • Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons
    • Schneider A., Rajendran L., Honsho M., Gralle M., Donnert G., Wouters F., Hell S.W., Simons M. Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J.Neurosci. 2008, 28:2874-2882.
    • (2008) J.Neurosci. , vol.28 , pp. 2874-2882
    • Schneider, A.1    Rajendran, L.2    Honsho, M.3    Gralle, M.4    Donnert, G.5    Wouters, F.6    Hell, S.W.7    Simons, M.8
  • 51
    • 0029586276 scopus 로고
    • Age-related production of new granule cells in the adult dentate gyrus
    • Seki T., Arai Y. Age-related production of new granule cells in the adult dentate gyrus. Neuroreport 1995, 6:2479-2482.
    • (1995) Neuroreport , vol.6 , pp. 2479-2482
    • Seki, T.1    Arai, Y.2
  • 52
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 53
    • 84861129061 scopus 로고    scopus 로고
    • Spatiotemporal changes to the subventricular zone stem cell pool through aging
    • Shook B.A., Manz D.H., Peters J.J., Kang S., Conover J.C. Spatiotemporal changes to the subventricular zone stem cell pool through aging. J.Neurosci. 2012, 32:6947-6956.
    • (2012) J.Neurosci. , vol.32 , pp. 6947-6956
    • Shook, B.A.1    Manz, D.H.2    Peters, J.J.3    Kang, S.4    Conover, J.C.5
  • 56
    • 0029942495 scopus 로고    scopus 로고
    • Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus
    • Thinakaran G., Teplow D.B., Siman R., Greenberg B., Sisodia S.S. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J.Biol. Chem. 1996, 271:9390-9397.
    • (1996) J.Biol. Chem. , vol.271 , pp. 9390-9397
    • Thinakaran, G.1    Teplow, D.B.2    Siman, R.3    Greenberg, B.4    Sisodia, S.S.5
  • 57
    • 0030826603 scopus 로고    scopus 로고
    • Transforming growth factor-α null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    • Tropepe V., Craig C.G., Morshead C.M., van der Kooy D. Transforming growth factor-α null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J.Neurosci. 1997, 17:7850-7859.
    • (1997) J.Neurosci. , vol.17 , pp. 7850-7859
    • Tropepe, V.1    Craig, C.G.2    Morshead, C.M.3    van der Kooy, D.4
  • 58
    • 84896590565 scopus 로고    scopus 로고
    • BACE1, the Alzheimer's beta-secretase enzyme, in health and disease
    • Vassar R. BACE1, the Alzheimer's beta-secretase enzyme, in health and disease. Mol. Neurodegener. 2012, 7(suppl 1):L3.
    • (2012) Mol. Neurodegener. , vol.7 , Issue.SUPPL. 1
    • Vassar, R.1
  • 61
    • 17444371643 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    • Zheng W., Nowakowski R.S., Vaccarino F.M. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Dev. Neurosci. 2004, 26:181-196.
    • (2004) Dev. Neurosci. , vol.26 , pp. 181-196
    • Zheng, W.1    Nowakowski, R.S.2    Vaccarino, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.