Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction

Circulation

Volumn 128, Issue 1, 2013, Pages 19-28

  Chung, Charles S ^a   Hutchinson, Kirk R ^a   Methawasin, Mei ^a   Saripalli, Chandra ^a   Smith, John E ^a   Hidalgo, Carlos G ^a   Luo, Xiuju ^a   Labeit, Siegfried ^b   Guo, Caiying ^c   Granzier, Henk L ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HHMI   (United States)

Author keywords

elasticity; exercise; extracellular matrix; hypertrophy; vascular stiffness

Indexed keywords

CONNECTIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN 11; IMMUNOGLOBULIN G3; PHOSPHOSPECIFIC ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL STIFFNESS; ARTICLE; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; EXERCISE TOLERANCE; EXON; EXTRACELLULAR MATRIX; HEART MUSCLE CELL; IMMUNOELECTRON MICROSCOPY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VISCOELASTICITY;

ELASTICITY; EXERCISE; EXTRACELLULAR MATRIX; HYPERTROPHY; VASCULAR STIFFNESS;

AGE FACTORS; ANIMALS; CARDIOMEGALY; DIASTOLE; DISEASE MODELS, ANIMAL; ELASTICITY; EXERCISE TOLERANCE; HEART FAILURE, DIASTOLIC; IMMUNOGLOBULINS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, IMMUNOELECTRON; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SARCOMERES;

EID: 84879753113     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.001268     Document Type: Article

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