Single molecule force spectroscopy of the cardiac titin N2B element: Effects of the molecular chaperone αB-crystallin with disease-causing mutations

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13914-13923

  Zhu, Yi ^a   Bogomolovas, Julius ^b   Labeit, Siegfried ^b   Granzier, Henk ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONTOUR LENGTHS; CRYSTALLIN; DILATED CARDIOMYOPATHY; FORCE-EXTENSION CURVES; HEART FUNCTION; MOLECULAR CHAPERONES; PERSISTENCE LENGTH; SINGLE MOLECULE; SINGLE MOLECULE FORCE SPECTROSCOPY; SMALL HEAT SHOCK PROTEINS; UNIQUE SEQUENCE; WILD TYPES;

RATE CONSTANTS;

MOLECULES;

ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; ARGININE; CHAPERONE; CONNECTIN; DESMIN; GLYCINE; HISTIDINE; IMMUNOGLOBULIN; TITIN N2B; UNCLASSIFIED DRUG; CRYAB PROTEIN, HUMAN; MUSCLE PROTEIN; PROTEIN KINASE;

ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; HUMAN; MISSENSE MUTATION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SINGLE MOLECULE FORCE SPECTROSCOPY; SPECTROSCOPY; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HEART MUSCLE; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ALPHA-CRYSTALLIN B CHAIN; AMINO ACID SUBSTITUTION; CARDIOMYOPATHY, DILATED; HUMANS; MUSCLE PROTEINS; MUTATION, MISSENSE; MYOCARDIUM; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY;

EID: 67649399290     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809743200     Document Type: Article

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