Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments

Journal of Structural Biology

Volumn 137, Issue 1-2, 2002, Pages 248-258

  Watanabe, Kaori ^a   Muhle Goll, Claudia ^b,c   Kellermayer, Miklós S Z ^a,d   Labeit, Siegfried ^c   Granzier, Henk ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CONNECTIN; IMMUNOGLOBULIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ATOMIC FORCE MICROSCOPY; CONFERENCE PAPER; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIMULATION;

EID: 18744374455     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2002.4458     Document Type: Conference Paper

References (39)

1. Bagni, M. A., Cecchi, G., Colomo, F., and Garzella, P. (1994) Development of stiffness precedes cross-bridge attachment during the early tension rise in single frog muscle fibres. J. Physiol. 481, 273-278.
2. Bang, M. L., Centner, T., Fornoff, F., Geach, A. J., Gotthardt, M., McNabb, M., Witt, C. C., Labeit, D., Gregorio, C. C., and Granzier, H., et al. (2001) The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ. Res. 89, 1065-1072.
3. Bustamante, C., Marko, J. F., Siggia, E. D., and Smith, S. (1994) Entropic elasticity of lambda-phage DNA. Science 265, 1599-1600.
4. Carrion-Vazquez, M., Oberhauser, A. F., Fisher, T. E., Marszalek, P. E., Li, H., and Fernandez, J. M. (2000) Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. Prog. Biophys. Mol. Biol. 74, 63-91.
5. Carrion-Vazquez, M., Oberhauser, A. F., Fowler, S. B., Marszalek, P. E., Broedel, S. E., Clarke, J., and Fernandez, J. M. (1999) Mechanical and chemical unfolding of a single protein: A comparison. Proc. Natl. Acad. Sci. USA 96, 3694-3699.
6. Freiburg, A., Trombitas, K., Hell, W., Cazorla, O., Fougerousse, F., Centner, T., Kolmerer, B., Witt, C., Beckmann, J. S., Gregorio, C. C., et al. (2000) Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. Circ. Res. 86, 1114-1121.
7. Gautel, M., and Goulding, D. (1996) A molecular map of titin/connectin elasticity reveals two different mechanisms acting in series. FEBS Lett 385, 11-14.
8. Gregorio, C. C., Granzier, H., Sorimachi, H., and Labeit, S. (1999) Muscle assembly: A titanic achievement? Curr. Opin. Cell. Biol. 11, 18-25.
9. Guerois, R., and Serrano, L. (2000) The SH3-fold family: Experimental evidence and prediction of variations in the folding pathways. J. Mol. Biol. 304, 967-982.
10. Harpaz, Y., and Chothia, C. (1994) Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J. Mol. Biol. 238, 528-539.
11. Higuchi, H., Nakauchi, Y., Maruyama, K., and Fujime, S. (1993) Characterization of beta-connectin (titin 2) from striated muscle by dynamic light scattering. Biophys. J. 65, 1906-1915.
12. Improta, S., Politou, A. S., and Pastore, A. (1996) Immunoglobulin-like modules from titin I-band: Extensible components of muscle elasticity. Structure 4, 323-337.
13. Kellermayer, M. S., Smith, S. B., Granzier, H. L., and Bustamante, C. (1997) Folding-unfolding transitions in single titin molecules characterized with laser tweezers. Science 276, 1112-1116.
14. Labeit, S., and Kolmerer, B. (1995) Titins: Giant proteins in charge of muscle ultrastructure and elasticity. Science 270, 293-296.
15. Li, H., Carrion-Vazquez, M., Oberhauser, A. F., Marszalek, P. E., and Fernandez, J. M. (2000a) Point mutations alter the mechanical stability of immunoglobulin modules. Nature Struct. Biol. 7, 1117-1120.
16. Li, H., Oberhauser, A. F., Fowler, S. B., Clarke, J., and Fernandez, J. M. (2000b) Atomic force microscopy reveals the mechanical design of a modular protein. Proc. Natl. Acad. Sci. USA 97, 6527-6531.
17. Li, H., Oberhauser, A. F., Redick, S. D., Carrion-Vazquez, M., Erickson, H. P., and Fernandez, J. M. (2001) Multiple conformations of PEVK proteins detected by single-molecule techniques. Proc. Natl. Acad. Sci. USA 98, 10682-10686.
18. Linke, W. A., and Granzier, H. (1998) A spring tale: New facts on titin elasticity. Biophys. J. 75, 2613-2614.
19. Linke, W. A., Ivemeyer, M., Mundel, P., Stockmeier, M. R., and Kolmerer, B. (1998) Nature of PEVK-titin elasticity in skeletal muscle. Proc. Natl. Acad. Sci. USA 95, 8052-8057.
20. Linke, W. A., Ivemeyer, M., Olivieri, N., Kolmerer, B., Ruegg, J. C., and Labeit, S. (1996) Towards a molecular understanding of the elasticity of titin. J. Mol. Biol. 261, 62-71.
21. Lu, H., Isralewitz, B., Krammer, A., Vogel, V., and Schulten, K. (1998) Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation. Biophys. J. 75, 662-671.
22. Lu, H., and Schulten, K. (2000) The key event in force-induced unfolding of titin's immunoglobulin domains. Biophys J. 79, 51-65.
23. Ma, K., Kan, L., and Wang, K. (2001) Polyproline II helix is a key structural motif of the elastic PEVK segment of titin. Biochemistry 40, 3427-3438.
24. Marszalek, P. E., Lu, H., Li, H., Carrion-Vazquez, M., Oberhauser, A. F., Schulten, K., and Fernandez, J. M. (1999) Mechanical unfolding intermediates in titin modules. Nature 402, 100-103.
25. Maruyama, K. (1997) Connectin/titin, giant elastic protein of muscle. FASEB J. 11, 341-345.
26. Minajeva, A., Kulke, M., Fernandez, J. M., and Linke, W. A. (2001) Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils. Biophys. J. 80, 1442-1451.
27. Muhle-Goll, C., Habeck, M., Cazorla, O., Nilges, M., Labeit, S., and Granzier, H. (2001) Structural and functional studies of titin's fibronectin type III modules reveal conserved surface patterns, binding to myosin S1- A possible role in the Frank-Starling mechanism of the heart. J. Mol. Biol. 313, 431-447.
28. Rief, M., Gautel, M., Oesterhelt, F., Fernandez, J. M., and Gaub, H. E. (1997) Reversible unfolding of individual titin immunoglobulin domains by AFM. Science 276, 1109-1112.
29. Rief, M., Gautel, M., Schemmel, A., and Gaub, H. E. (1998) The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy. Biophys. J. 75, 3008-3014.
30. Rief, M., Pascual, J., Saraste, M., and Gaub, H. E. (1999) Single molecule force spectroscopy of spectrin repeats: Low unfolding forces in helix bundles. J. Mol. Biol. 286, 553-561.
31. Sali, A., and Blundell, T. L. (1993) Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815.
32. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25, 4876-4882.
33. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680.
34. Trinick, J., and Tskhovrebova, L. (1999) Titin: A molecular control freak. Trends Cell Biol. 9, 377-380.
35. Trombitas, K., Greaser, M., Labeit, S., Jin, J. P., Kellermayer, M., Helmes, M., and Granzier, H. (1998) Titin extensibility in situ: Entropic elasticity of permanently folded and permanently unfolded molecular segments. J. Cell Biol. 140, 853-859.
36. Tskhovrebova, L., and Trinick, J. (2001) Flexibility and extensibility in the titin molecule: Analysis of electron microscope data. J. Mol. Biol. 310, 755-771.
37. Tskhovrebova, L., Trinick, J., Sleep, J. A., and Simmons, R. M. (1997) Elasticity and unfolding of single molecules of the giant muscle protein titin. Nature 387, 308-312.
38. Wang, K. (1996) Titin/connectin and nebulin: Giant protein rulers of muscle structure and function. Adv. Biophys. 33, 123-134.
39. Witt, C. C., Olivieri, N., Centner, T., Kolmerer, B., Millevoi, S., Morell, J., Labeit, D., Labeit, S., Jockusch, H., and Pastore, A. (1998) A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. J. Struct. Biol. 122, 206-215.