Retinal vascular geometry in Asian persons with diabetes and retinopathy

Journal of Diabetes Science and Technology

Volumn 6, Issue 3, 2012, Pages 595-605

  Cheung, Carol Yim Lui ^a,b   Lamoureux, Ecosse ^a,c   Ikram, Kamran ^b,d   Sasongko, M Bayu ^c,e   Ding, Jie ^a   Zheng, Yingfeng ^a   Mitchell, Paul ^f   Wang, Jie Jin ^c,f   Wong, Tien Yin ^a,b  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e GADJAH MADA UNIVERSITY   (Indonesia)

^f UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Diabetes; Epidemiology; Imaging; Retinopathy

Indexed keywords

ANTIDIABETIC AGENT; HEMOGLOBIN A1C;

ADULT; AGED; ARTICLE; ASIAN; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; DIABETES MELLITUS; DRUG USE; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; PHOTOGRAPHY; QUANTITATIVE ANALYSIS; RETINA BLOOD VESSEL; RETINAL VASCULAR BRANCHING ANGLE; RETINAL VASCULAR CALIBER; RETINAL VASCULAR FRACTAL DIMENSION; RETINAL VASCULAR GEOMETRY; RETINAL VASCULAR TORTUOSITY; RETINOPATHY; SMOKING; SYSTOLIC BLOOD PRESSURE; VISUAL SYSTEM EXAMINATION; VISUAL SYSTEM PARAMETERS; COMPUTER ASSISTED DIAGNOSIS; CROSS-SECTIONAL STUDY; DIABETIC RETINOPATHY; ETHNOLOGY; FEMALE; LABORATORY AUTOMATION; MALAYSIA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PREDICTIVE VALUE; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SINGAPORE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOMATION, LABORATORY; CROSS-SECTIONAL STUDIES; DIABETIC RETINOPATHY; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALAYSIA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; RETINAL VESSELS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SINGAPORE;

EID: 84879711304     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681200600315     Document Type: Article

References (56)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4-14.
2. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124-36.
3. Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ, Geiss LS, Gregg EW, Albright AL, Klein BE, Klein R. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA. 2010;304(6):649-56.
4. Wong TY, Klein R, Sharrett AR, Schmidt MI, Pankow JS, Couper DJ, Klein BE, Hubbard LD, Duncan BB; ARIC Investigators. Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. JAMA. 2002;287(19):2528-33.
5. Wong TY, Shankar A, Klein R, Klein BE, Hubbard LD. Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus. Arch Intern Med. 2005;165(9):1060-5.
6. Nguyen TT, Wang JJ, Islam FM, Mitchell P, Tapp RJ, Zimmet PZ, Simpson R, Shaw J, Wong TY. Retinal arteriolar narrowing predicts incidence of diabetes: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. Diabetes. 2008;57(3):536-9.
7. Nguyen TT, Wong TY. Retinal vascular changes and diabetic retinopathy. Curr Diab Rep. 2009;9(4):277-83.
8. Wong TY, Shankar A, Klein R, Klein BE. Retinal vessel diameters and the incidence of gross proteinuria and renal insuficiency in people with type 1 diabetes. Diabetes. 2004;53(1):179-84.
9. Klein R, Klein BE, Moss SE, Wong TY. Retinal vessel caliber and microvascular and macrovascular disease in type 2 diabetes: XXI: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Ophthalmology. 2007;114(10):1884- 92.
10. Kifley A, Wang JJ, Cugati S, Wong TY, Mitchell P. Retinal vascular caliber, diabetes, and retinopathy. Am J Ophthalmol. 2007;143(6):1024-6.
11. Nguyen TT, Wang JJ, Sharrett AR, Islam FM, Klein R, Klein BE, Cotch MF, Wong TY. Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2008;31(3):544-9.
12. Wong TY, Coresh J, Klein R, Muntner P, Couper DJ, Sharrett AR, Klein BE, Heiss G, Hubbard LD, Duncan BB. Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study. J Am Soc Nephrol. 2004;15(9):2469-76.
13. Klein R, Klein BE, Moss SE, Wong TY, Hubbard L, Cruickshanks KJ, Palta M. The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol. 2004;122(1):76-83.
14. Murray CD. The physiological principle of minimum work: I. the vascular system and the cost of blood volume. Proc Natl Acad Sci U S A. 1926;12(3):207-14.
15. Changizi MA, Cherniak C. Modeling the large-scale geometry of human coronary arteries. Can J Physiol Pharmacol. 2000;78(8):603-11.
16. Rossitti S, Löfgren J. Optimality principles and flow orderliness at the branching points of cerebral arteries. Stroke. 1993;24(7):1029-32.
17. Grauslund J, Green A, Kawasaki R, Hodgson L, Sjolie AK, Wong TY. Retinal vascular fractals and microvascular and macrovascular complications in type 1 diabetes. Ophthalmology. 2010;117(7):1400-5.
18. Sasongko MB, Wang JJ, Donaghue KC, Cheung N, Benitez-Aguirre P, Jenkins A, Hsu W, Lee ML, Wong TY. Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care. 2010;33(6):1331-6.
19. Cheung N, Donaghue KC, Liew G, Rogers SL, Wang JJ, Lim SW, Jenkins AJ, Hsu W, Li Lee M, Wong TY. Quantitative assessment of early diabetic retinopathy using fractal analysis. Diabetes Care. 2009;32(1):106-10.
20. Benitez-Aguirre P, Craig ME, Sasongko MB, Jenkins AJ, Wong TY, Wang JJ, Cheung N, Donaghue KC. Retinal Vascular Geometry Predicts Incident Retinopathy in Young People With Type 1 Diabetes: A prospective cohort study from adolescence. Diabetes Care. 2011;34(7):1622-7.
21. Cheung CY, Zheng Y, Hsu W, Lee ML, Lau QP, Mitchell P, Wang JJ, Klein R, Wong TY. Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors. Ophthalmology. 2011;118(5):812-8.
22. Cheung CY, Hsu W, Lee ML, Wang JJ, Mitchell P, Lau QP, Hamzah H, Ho M, Wong TY. A new method to measure peripheral retinal vascular caliber over an extended area. Microcirculation. 2010;17(7):495-503.
23. Liew G, Wang JJ, Cheung N, Zhang YP, Hsu W, Lee ML, Mitchell P, Tikellis G, Taylor B, Wong TY. The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure. Ophthalmology. 2008;115(11):1951-6.
24. Hughes AD, Martinez-Perez E, Jabbar AS, Hassan A, Witt NW, Mistry PD, Chapman N, Stanton AV, Beevers G, Pedrinelli R, Parker KH, Thom SA. Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J Hypertens. 2006;24(5):889-94.
25. Cheung N, Liew G, Lindley RI, Liu EY, Wang JJ, Hand P, Baker M, Mitchell P, Wong TY; Multi-Center Retina & Stroke Study Collaborative Group. Retinal fractals and acute lacunar stroke. Ann Neurol. 2010;68(1):107-11.
26. Doubal FN, MacGillivray TJ, Patton N, Dhillon B, Dennis MS, Wardlaw JM. Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke. Neurology. 2010;74(14):1102-7.
27. Sng CC, Sabanayagam C, Lamoureux EL, Liu E, Lim SC, Hamzah H, Lee J, Tai ES, Wong TY. Fractal analysis of the retinal vasculature and chronic kidney disease. Nephrol Dial Transplant. 2010;25(7):2252-8.
28. Sasongko MB, Wang JJ, Donaghue KC, Cheung N, Benitez-Aguirre P, Jenkins A, Hsu W, Lee ML, Wong TY. Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care. 2010;33(6):1331-6.
29. Foong AW, Saw SM, Loo JL, Shen S, Loon SC, Rosman M, Aung T, Tan DT, Tai ES, Wong TY. Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES). Ophthalmic Epidemiol. 2007;14(1):25-35.
30. Hart WE, Goldbaum M, Cote B, Kube P, Nelson MR. Measurement and classification of retinal vascular tortuosity. Int J Med Inform. 1999;53(2-3):239-52.
31. Zamir M, Medeiros JA, Cunningham TK. Arterial bifurcations in the human retina. J Gen Physiol. 1979;74(4):537-48.
32. Mainster MA. The fractal properties of retinal vessels: embryological and clinical implications. Eye (Lond). 1990;4(Pt 1):235-41.
33. Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS, Sharrett AR, Davis MD, Cai J. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology. 1999;106(12):2269-80.
34. Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res. 2003;27(3):143-9.
35. Cheung CY, Tay WT, Mitchell P, Wang JJ, Hsu W, Lee ML, Lau QP, Zhu AL, Klein R, Saw SM, Wong TY. Quantitative and qualitative retinal microvascular characteristics and blood pressure. J Hypertens. 2011;29(7):1380-91.
36. Wong TY, Klein R, Islam FM, Cotch MF, Folsom AR, Klein BE, Sharrett AR, Shea S. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol. 2006;141(3):446-455.
37. Wong TY, Cheung N, Tay WT, Wang JJ, Aung T, Saw SM, Lim SC, Tai ES, Mitchell P. Prevalence and risk factors for diabetic retinopathy: the Singapore Malay Eye Study. Ophthalmology. 2008;115(11):1869-75.
38. Islam FM, Nguyen TT, Wang JJ, Tai ES, Shankar A, Saw SM, Aung T, Lim SC, Mitchell P, Wong TY. Quantitative retinal vascular calibre changes in diabetes and retinopathy: the Singapore Malay eye study. Eye (Lond). 2009;23(8):1719-24.
39. Witt N, Wong TY, Hughes AD, Chaturvedi N, Klein BE, Evans R, McNamara M, Thom SA, Klein R. Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension. 2006;47(5):975-81.
40. Stettler C, Witt N, Tapp RJ, Thom S, Allemann S, Tillin T, Stanton A, O'Brien E, Poulter N, Gallimore JR, Hughes AD, Chaturvedi N. Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy. Diabetes Care. 2009;32(6):1098-100.
41. Sasongko MB, Wong TY, Nguyen TT, Cheung CY, Shaw JE, Wang JJ. Retinal vascular tortuosity in persons with diabetes and diabetic retinopathy. Diabetologia. 2011;54(9):2409-16.
42. Konno S, Feke GT, Yoshida A, Fujio N, Goger DG, Buzney SM. Retinal blood flow changes in type I diabetes. A long-term follow-up study. Invest Ophthalmol Vis Sci. 1996;37(6):1140-8.
43. Curtis TM, Gardiner TA, Stitt AW. Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye (Lond). 2009;23(7):1496-508.
44. Nagaoka T, Sato E, Takahashi A, Yokota H, Sogawa K, Yoshida A. Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study. Invest Ophthalmol Vis Sci. 2010;51(12):6729-34.
45. Jeganathan VS, Cheung N, Tay WT, Wang JJ, Mitchell P, Wong TY. Prevalence and risk factors of retinopathy in an Asian population without diabetes: the Singapore Malay Eye Study. Arch Ophthalmol. 2010;128(1):40-5.
46. Yu T, Mitchell P, Berry G, Li W, Wang JJ. Retinopathy in older persons without diabetes and its relationship to hypertension. Arch Ophthalmol. 1998;116(1):83-9.
47. Klein R. Retinopathy in a population-based study. Trans Am Ophthalmol Soc. 1992;90:561-94.
48. Peng XY, Wang FH, Liang YB, Wang JJ, Sun LP, Peng Y, Friedman DS, Liew G, Wang NL, Wong TY. Retinopathy in persons without diabetes: the Handan Eye Study. Ophthalmology. 2010;117(3):531-7.
49. Nguyen TT, Wang JJ, Wong TY. Retinal vascular changes in prediabetes and prehypertension: new findings and their research and clinical implications. Diabetes Care. 2007;30(10):2708-15.
50. Lim SW, Cheung N, Wang JJ, Donaghue KC, Liew G, Islam FM, Jenkins AJ, Wong TY. Retinal vascular fractal dimension and risk of early diabetic retinopathy: a prospective study of children and adolescents with type 1 diabetes. Diabetes Care. 2009;32(11):2081-3.
51. Parsons-Wingerter P, Radhakrishnan K, Vickerman MB, Kaiser PK. Oscillation of angiogenesis with vascular dropout in diabetic retinopathy by VESsel GENeration analysis (VESGEN). Invest Ophthalmol Vis Sci. 2010;51(1):498-507.
52. Avakian A, Kalina RE, Sage EH, Rambhia AH, Elliott KE, Chuang EL, Clark JI, Hwang JN, Parsons-Wingerter P. Fractal analysis of region-based vascular change in the normal and non-proliferative diabetic retina. Curr Eye Res. 2002;24(4):274-80.
53. Yau JW, Kawasaki R, Islam FM, Shaw J, Zimmet P, Wang JJ, Wong TY. Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Diabetologia. 2010;53(9):2042-5.
54. Stanton AV, Wasan B, Cerutti A, Ford S, Marsh R, Sever PP, Thom SA, Hughes AD. Vascular network changes in the retina with age and hypertension. J Hypertens. 1995;13(12 Pt 2):1724-8.
55. Cosatto VF, Liew G, Rochtchina E, Wainwright A, Zhang Y, Hsu W, Lee ML, Lau QP, Hamzah HH, Mitchell P, Wong TY, Wang JJ. Retinal vascular fractal dimension measurement and its influence from imaging variation: results of two segmentation methods. Curr Eye Res. 2010;35(9):850-6.
56. Knudtson MD, Klein BE, Klein R, Wong TY, Hubbard LD, Lee KE, Meuer SM, Bulla CP. Variation associated with measurement of retinal vessel diameters at diferent points in the pulse cycle. Br J Ophthalmol. 2004;88(1):57-61.