Impaired retinal circulation in patients with type 2 diabetes mellitus: Retinal laser doppler velocimetry study

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 12, 2010, Pages 6729-6734

  Nagaoka, Taiji ^a   Sato, Eiichi ^a   Takahashi, Atsushi ^a   Yokota, Harumasa ^a   Sogawa, Kenji ^a   Yoshida, Akitoshi ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; HEMOGLOBIN A1C; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTERY DIAMETER; ARTERY WALL; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEMODYNAMICS; HUMAN; LASER DOPPLER FLOWMETRY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RETINA BLOOD FLOW; RETINA ISCHEMIA; SHEAR RATE;

ADULT; AGED; AGED, 80 AND OVER; BLOOD CIRCULATION; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BLOOD PRESSURE; CREATININE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INTRAOCULAR PRESSURE; LASER-DOPPLER FLOWMETRY; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; RETINAL ARTERY;

EID: 79955969572     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5364     Document Type: Article

References (50)

1. Konno S, Feke GT, Yoshida A, et al. Retinal blood flow changes in type I diabetes: a long-term follow-up study. Invest Ophthalmol Vis Sci. 1996;37:1140-1148.
2. Bursell SE, Clermont AC, Kinsley BT, et al. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci. 1996;37:886-897.
3. Grunwald JE, Riva CE, Sinclair SH, et al. Laser Doppler velocimetry study of retinal circulation in diabetes mellitus. Arch Ophthalmol. 1986;104:991-996.
4. Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997;14(suppl 5):S1-S85.
5. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(suppl 1):S5-S20.
6. Klein BE, Davis MD, Segal P, et al. Diabetic retinopathy: assessment of severity and progression. Ophthalmology. 1984;91:10 -17.
7. Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of diabetic retinopathy. XIV: ten-year incidence and progression of diabetic retinopathy. Arch Ophthalmol. 1994;112:1217-1228.
8. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs: an extension of the modified Airlie House classification. ETDRS report number 10. Ophthalmology. 1991;98:786-806.
9. Yoshida A, Feke GT, Mori F, et al. Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument. Am J Ophthalmol. 2003;135:356-361.
10. Nagaoka T, Yoshida A. Noninvasive evaluation of wall shear stress on retinal microcirculation in humans. Invest Ophthalmol Vis Sci. 2006;47:1113-1119.
11. Littmann H. Determining the true size of an object on the fundus of the living eye (in German). Klin Monatsbl Augenheilkd. 1988; 192:66-67.
12. Alm A, Bill A. Ocular circulation. In: Hart WMJ, ed. Adler's Physiology of the Eye. 9th ed. St. Louis: Mosby; 1992;198-227.
13. Nagaoka T, Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A. Effect of aging on retinal circulation in normotensive healthy subjects. Exp Eye Res. 2009;89:887-891.
14. Nagaoka T, Ishii Y, Takeuchi T, et al. Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis. Invest Ophthalmol Vis Sci. 2005;46:720-725.
15. Pourcelot L. Indications of Doppler's ultrasonography in the study of peripheral vessels (in French). Rev Prat. 1975;25:4671-4680.
16. Sato E, Feke GT, Menke MN, McMeel J. Retinal haemodynamics in patients with age-related macular degeneration. Eye. 2006;20:697-702.
17. Patel V, Rassam S, Newsom R, et al. Retinal blood flow in diabetic retinopathy. BMJ. 1992;305:678-683.
18. Clermont AC, Aiello LP, Mori F, et al. Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy. Am J Ophthalmol. 1997;124:433-446.
19. Bursell SE, Clermont AC, Aiello LP, et al. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care. 1999; 22:1245-1251.
20. Takagi C, Bursell SE, Lin YW, et al. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996;37:2504-2518.
21. Kunisaki M, Bursell SE, Clermont AC, et al. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995;269:E239-F246.
22. Kunisaki M, Bursell SE, Umeda F, et al. Prevention of diabetesinduced abnormal retinal blood flow by treatment with d-alphatocopherol. Biofactors. 1998;7:55- 67.
23. Irace C, Carallo C, Crescenzo A, et al. NIDDM is associated with lower wall shear stress of the common carotid artery. Diabetes. 1999;48:193-197.
24. Feke GT, Buzney SM, Ogasawara H, et al. Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci. 1994; 35:2968-2975.
25. Sheetz MJ, King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 2002;288:2579-2588.
26. Horio N, Clermont AC, Abiko A, et al. Angiotensin AT(1) receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodilatation in normotensive diabetic rats. Diabetologia. 2004;47:113-123.
27. Sogawa K, Nagaoka T, Izumi N, et al. Acute hyperglycemia induces endothelial dysfunction in the retinal arterioles in cats. Invest Ophthalmol Vis Sci. 2010;51:2648-2655.
28. Feng D, Bursell SE, Clermont AC, et al. von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes. Diabetes Care. 2000;23:1694-1698.
29. Nagaoka T, Mori F, Yoshida A. Retinal artery response to acute systemic blood pressure increase during cold pressor test in humans. Invest Ophthalmol Vis Sci. 2002;43:1941-1945.
30. Nagaoka T, Sakamoto T, Mori F, et al. The effect of nitric oxide on retinal blood flow during hypoxia in cats. Invest Ophthalmol Vis Sci. 2002;43:3037-3044.
31. Miyamoto K, Khosrof S, Bursell SE, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A. 1999;96:10836-10841.
32. Joussen AM, Poulaki V, Mitsiades N, et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002;16:438-440.
33. McLeod DS, Lefer DJ, Merges C, Lutty GA. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol. 1995;147:642-653.
34. Ando J, Tsuboi H, Korenaga R, et al. Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression. Am J Physiol. 1994;267:C679-C687.
35. Tsao PS, Lewis NP, Alpert S, Cooke JP. Exposure to shear stress alters endothelial adhesiveness: role of nitric oxide. Circulation. 1995;92:3513-3519.
36. Miyahara S, Kiryu J, Yamashiro K, et al. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes. Am J Pathol. 2004;164: 1697-1706.
37. Walpola PL, Gotlieb AI, Langille BL. Monocyte adhesion and changes in endothelial cell number, morphology, and F-actin distribution elicited by low shear stress in vivo. Am J Pathol. 1993; 142:1392-1400.
38. Walpola PL, Gotlieb AI, Cybulsky MI, Langille BL. Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol. 1995;15:2-10.
39. Guan K, Hudson C, Wong T, Kisilevsky M, et al. Retinal hemodynamics in early diabetic macular edema. Diabetes. 2006;55:813-818.
40. Sachinidis A, Mengden T, Locher R, et al. Novel cellular activities for low density lipoprotein in vascular smooth muscle cells. Hypertension. 1990;15:704-711.
41. Tasaki H, Yamashita K, Nakashima Y, et al. Increase in intracellular calcium ion in smooth muscle cells induced by low-density lipoprotein. Gerontology. 1994;40(suppl 2):23-28.
42. Sachinidis A, Locher R, Steiner A, et al. Effect of low-density lipoprotein on intracellular calcium, intracellular pH and DNA synthesis in cultured vascular smooth muscle cells. J Hypertens. 1989;6 (suppl 7):S116-S117.
43. Skinner S, Locher R, Niederer E, Vetter W. Can low density lipoprotein influence microvascular caliber? Microvasc Res. 1998; 55:241-248.
44. Frank RN. On the pathogenesis of diabetic retinopathy: a 1990 update. Ophthalmology. 1991;98:586-593.
45. Frank RN, Turczyn TJ, Das A. Pericyte coverage of retinal and cerebral capillaries. Invest Ophthalmol Vis Sci. 1990;31:999-1007.
46. Rassam SM, Patel V, Kohner EM. The effect of experimental hypertension on retinal vascular autoregulation in humans: a mechanism for the progression of diabetic retinopathy. Exp Physiol. 1995;80:53-68.
47. Bertram B, Wolf S, Fiehofer S, et al. Retinal circulation times in diabetes mellitus type 1. Br J Ophthalmol. 1991;75:462-465.
48. Tikellis G, Wang J, Tapp R, et al. The relationship of retinal vascular caliber to diabetes and retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. Diabetologia. 2007;50: 2263-2271.
49. Nguyen T, Wang J, Sharrett A, et al. Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2008;31:544-549.
50. Grunwald JE, Riva CE, Baine J, Brucker AJ. Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control. Invest Ophthalmol Vis Sci. 1992;33:356-363.