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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4308-4314

Discovery of triazines as potent, selective and orally active PDE4 inhibitors

(3) Gewald, Rainer a Grunwald, Christian a Egerland, Ute a

a Biocrea GmbH (Germany)

Author keywords

COPD; Neutrophilia; PDE4 inhibitor; Phosphodiesterase; Triazine

Indexed keywords

PHOSPHODIESTERASE IV INHIBITOR; TRIAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; MICROSOMES, LIVER; MOLECULAR DOCKING SIMULATION; PHOSPHODIESTERASE 4 INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84879691026 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.099 Document Type: Article

Times cited : (34)

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