Synthesis and biological activity of pyrido[3′,2′:4,5]furo[3,2- d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4946-4956

  Taltavull, Joan ^a   Serrat, Jordi ^a   Grcia, Jordi ^a   Gavald, Amadeu ^a   Córdoba, Mnica ^a   Calama, Elena ^a   Montero, José Luis ^a   Andrés, Míriam ^a   Miralpeix, Montserrat ^a   Vilella, Dolors ^a   Hernández, Begoña ^a   Beleta, Jorge ^a   Ryder, Hamish ^b   Pags, Lluís ^a  

^a RandD Centre ^*  (Spain)

^b Angel Building   (United Kingdom)

Author keywords

chronic obstructive pulmonary disease; COPD; PDE4; PFP; phosphodiesterase type 4; pyrido 3 ,2 :4,5 furo 3,2 d pyrimidine

Indexed keywords

AMINE; PHOSPHODIESTERASE IV INHIBITOR; PYRIDINE; PYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; PYRIMIDINE DERIVATIVE; ROFLUMILAST; SCAFFOLD PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; BIOLOGICAL ACTIVITY; CELL STRAIN CACO 2; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG HYDROLYSIS; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FERRET; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LOW DRUG DOSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; ASTHMA; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FERRETS; HUMANS; MODELS, MOLECULAR; PHOSPHODIESTERASE 4 INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053178005     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.054     Document Type: Article

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