Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7089-7093

  Nankervis, Jacob L ^a   Feil, Susanne C ^b   Hancock, Nancy C ^b   Zheng, Zhaohua ^a   Ng, Hooi Ling ^b   Morton, Craig J ^b   Holien, Jessica K ^b   Ho, Patricia W M ^b   Frazzetto, Mark M ^a   Jennings, Ian G ^a   Manallack, David T ^a   John Martin, T ^b   Thompson, Philip E ^a   Parker, Michael W ^b,c  

^a MONASH UNIVERSITY   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Crystallography; Gewald reaction; PDE4; Phosphodiesterase inhibitors; Thiophene

Indexed keywords

PARATHYROID HORMONE RECEPTOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV D2; PHOSPHODIESTERASE IV INHIBITOR; THIOPHENE; UMR 106; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED CLINICAL TRIAL; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; MODELS, MOLECULAR; PHOSPHODIESTERASE 4 INHIBITORS; PROTEIN BINDING; THIOPHENES;

EID: 80255137205     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.109     Document Type: Article

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