Discovery of oxazole-based PDE4 inhibitors with picomolar potency

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2594-2597

  Kuang, Rongze ^a   Shue, Ho Jane ^a   Xiao, Li ^a   Blythin, David J ^a   Shih, Neng Yang ^a   Chen, Xiao ^a   Gu, Danlin ^a   Schwerdt, John ^a   Lin, Ling ^a   Ting, Pauline C ^a   Cao, Jianhua ^a   Aslanian, Robert ^a   Piwinski, John J ^a   Prelusky, Daniel ^a   Wu, Ping ^a   Zhang, Ji ^a   Zhang, Xiang ^a   Celly, Chander S ^a   Billah, Motasim ^a   Wang, Peng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Inflammation; Oxazole; PDE4 inhibitor; Phosphodiesterase 4; Picomolar

Indexed keywords

OXAZOLE; PHOSPHODIESTERASE IV INHIBITOR;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DEVELOPMENT; IN VIVO STUDY; REACTION OPTIMIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLIC N-OXIDES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; OXAZOLES; PHOSPHODIESTERASE 4 INHIBITORS; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862779566     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.115     Document Type: Article

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