Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 3, 1999, Pages 509-516

  Leroux, F ^a   Van Keulen, B J ^b   Daliers, J ^b   Pommery, N ^a   Henichart J P ^a  

^a Institut de Chimie Pharmaceutique   (France)

^b UCB PHARMA   (Belgium)

Author keywords

Antiinflammatories; Bronchodilators; Enzyme inhibitors; Substituent effects

Indexed keywords

PHOSPHODIESTERASE IV INHIBITOR; PICLAMILAST; ROLIPRAM; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; GUINEA PIG; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; RATS; TRACHEA; TRIAZINES;

EID: 0032977802     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00266-1     Document Type: Article

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