Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 2, 2007, Pages 182-185

  Chappie, Thomas A ^a   Humphrey, John M ^a   Allen, Martin P ^a   Estep, Kimberly G ^a   Fox, Carol B ^a   Lebel, Lorraine A ^a   Liras, Spiros ^a   Marr, Eric S ^a   Menniti, Frank S ^a   Pandit, Jayvardhan ^a   Schmidt, Christopher J ^a   Tu, Meihua ^a   Williams, Robert D ^a   Yang, Feng V ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIMETHOXY 4 PYRROLIDYLQUINAZOLINE; BRAIN ENZYME; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP; ENZYME INHIBITOR; PAPAVERINE; PHOSPHODIESTERASE 10 A; PHOSPHODIESTERASE 10 A INHIBITOR; PHOSPHODIESTERASE 3 A; PHOSPHODIESTERASE 3 B; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; NONHUMAN; PHARMACOPHORE; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ANIMALS; CORPUS STRIATUM; CRYSTALLOGRAPHY, X-RAY; CYCLIC GMP; MICE; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRROLIDINES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846451429     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060653b     Document Type: Article

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