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Volumn 14, Issue 2, 2013, Pages 207-216

The role of endothelial insulin signaling in the regulation of glucose metabolism

Author keywords

Capillary recruitment; Endothelial cell; Endothelial nitric oxide synthase; Insulin signaling; Insulin transport; Skeletal muscle insulin resistance

Indexed keywords

1 METHYLXANTHINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N(G) METHYLARGININE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RAS PROTEIN; SOS PROTEIN;

EID: 84879690756     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-013-9242-z     Document Type: Article
Times cited : (34)

References (88)
  • 1
    • 84858702540 scopus 로고    scopus 로고
    • The worldwide epidemiology of type 2 diabetes mellitus present and future perspectives
    • 22064493 10.1038/nrendo.2011.183 1:CAS:528:DC%2BC38Xkt1Chs70%3D
    • Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus present and future perspectives. Nat Rev Endocrinol. 2011;8:228-36.
    • (2011) Nat Rev Endocrinol. , vol.8 , pp. 228-236
    • Chen, L.1    Magliano, D.J.2    Zimmet, P.Z.3
  • 2
    • 66149131064 scopus 로고    scopus 로고
    • Diabetes in Asia: Epidemiology, risk factors, and pathophysiology
    • 19470990 10.1001/jama.2009.726 1:CAS:528:DC%2BD1MXmsFaks7k%3D
    • Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009;301:2129-40.
    • (2009) JAMA. , vol.301 , pp. 2129-2140
    • Chan, J.C.1    Malik, V.2    Jia, W.3    Kadowaki, T.4    Yajnik, C.S.5    Yoon, K.H.6
  • 3
    • 12944320328 scopus 로고    scopus 로고
    • Prediction of the risk of cardiovascular mortality using a score that includes glucose as a risk factor: The DECODE Study
    • 15662552 10.1007/s00125-004-1574-5 1:STN:280:DC%2BD2M%2FmtF2ksA%3D%3D
    • Balkau B, Hu G, Qiao Q, Tuomilehto J, Borch-Johnsen K, Pyorala K. Prediction of the risk of cardiovascular mortality using a score that includes glucose as a risk factor: The DECODE Study. Diabetologia. 2004;47:2118-28.
    • (2004) Diabetologia , vol.47 , pp. 2118-2128
    • Balkau, B.1    Hu, G.2    Qiao, Q.3    Tuomilehto, J.4    Borch-Johnsen, K.5    Pyorala, K.6
  • 4
    • 43849095463 scopus 로고    scopus 로고
    • Cardiovascular disease risk in type 2 diabetes mellitus: Insights from mechanistic studies
    • 18502305 10.1016/S0140-6736(08)60768-0 1:CAS:528:DC%2BD1cXmt1Ontro%3D
    • Mazzone T, Chait A, Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet. 2008;371:1800-9.
    • (2008) Lancet , vol.371 , pp. 1800-1809
    • Mazzone, T.1    Chait, A.2    Plutzky, J.3
  • 5
    • 0043244907 scopus 로고    scopus 로고
    • American diabetes association: Economic costs of diabetes in the US in 2002
    • 12610059 10.2337/diacare.26.3.917
    • Hogan P, Dall T, Nikolov P. American diabetes association: economic costs of diabetes in the US in 2002. Diabetes Care. 2003;26:917-32.
    • (2003) Diabetes Care , vol.26 , pp. 917-932
    • Hogan, P.1    Dall, T.2    Nikolov, P.3
  • 6
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • 3894418 10.1172/JCI111938 1:STN:280:DyaL2M3mtF2lsw%3D%3D
    • DeFronzo R, Gunnarsson R, Ojorkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest. 1985;76:149-55.
    • (1985) J Clin Invest , vol.76 , pp. 149-155
    • Defronzo, R.1    Gunnarsson, R.2    Ojorkman, O.3    Olsson, M.4    Wahren, J.5
  • 7
    • 0025123408 scopus 로고
    • 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo
    • 2211599 1:CAS:528:DyaK3cXlvV2isLc%3D
    • Turinsky J, O'Sullivan DM, Bayly BP. 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J Biol Chem. 1990;265:16880-5.
    • (1990) J Biol Chem , vol.265 , pp. 16880-16885
    • Turinsky, J.1    O'Sullivan, D.M.2    Bayly, B.P.3
  • 8
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • 9916137 10.1172/JCI5001 1:CAS:528:DyaK1MXltFequw%3D%3D
    • Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999;103:253-9.
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 9
    • 0036300538 scopus 로고    scopus 로고
    • Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • 12086926 10.2337/diabetes.51.7.2005 1:CAS:528:DC%2BD38Xlt1Wls7c%3D
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002;51:2005-11.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 10
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • 21490391 10.1172/JCI43378 1:CAS:528:DC%2BC3MXlvFKnt7Y%3D
    • Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest. 2011;121:1858-70.
    • (2011) J Clin Invest , vol.121 , pp. 1858-1870
    • Holland, W.L.1    Bikman, B.T.2    Wang, L.P.3    Yuguang, G.4    Sargent, K.M.5    Bulchand, S.6
  • 11
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • 22385956 10.1016/j.cell.2012.02.017 1:CAS:528:DC%2BC38XjtlSgtrg%3D
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012;148:852-71.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 12
    • 53149116286 scopus 로고    scopus 로고
    • Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle
    • 10.1152/ajpendo.90259.2008 1:CAS:528:DC%2BD1cXhtFCgt77I
    • Long YC, Zierath JR. Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle. Am J Physiol Endocrinol Metab. 2008;295:E545-52.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. 545-552
    • Long, Y.C.1    Zierath, J.R.2
  • 13
    • 17844402218 scopus 로고    scopus 로고
    • Active role for the vasculature in the delivery of insulin to skeletal muscle
    • 15810996 10.1111/j.1440-1681.2005.04188.x 1:CAS:528:DC%2BD2MXjvFSqtbw%3D
    • Vincent MA, Clerk LH, Rattigan S, Clark MG, Barrett EJ. Active role for the vasculature in the delivery of insulin to skeletal muscle. Clin Exp Pharmacol Physiol. 2005;32:302-7.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 302-307
    • Vincent, M.A.1    Clerk, L.H.2    Rattigan, S.3    Clark, M.G.4    Barrett, E.J.5
  • 14
    • 0024423823 scopus 로고
    • Insulin transport across capillaries is rate limiting for insulin action in dogs
    • 2681272 10.1172/JCI114339 1:CAS:528:DyaK3cXhtVGj
    • Yang YJ, Hope ID, Ader M, Bergman RN. Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest. 1989;84:1620-8.
    • (1989) J Clin Invest , vol.84 , pp. 1620-1628
    • Yang, Y.J.1    Hope, I.D.2    Ader, M.3    Bergman, R.N.4
  • 15
    • 0027313517 scopus 로고
    • Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin
    • 8375586 10.2337/diabetes.42.10.1469 1:CAS:528:DyaK3sXms1aqtb4%3D
    • Jansson PA, Fowelin JP, von Schenck HP, Smith UP, Lönnroth PN. Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin. Diabetes. 1993;42:1469-73.
    • (1993) Diabetes , vol.42 , pp. 1469-1473
    • Jansson, P.A.1    Fowelin, J.P.2    Von Schenck, H.P.3    Smith, U.P.4    Lönnroth, P.N.5
  • 16
    • 0029151869 scopus 로고
    • Kinetics of insulin action in vivo. Identification of rate limiting steps
    • 7622001 10.2337/diabetes.44.8.947 1:CAS:528:DyaK2MXnsVSntrk%3D
    • Miles PD, Levisetti M, Reichart D, Khoursheed M, Moossa AR, Olefsky JM. Kinetics of insulin action in vivo. Identification of rate limiting steps. Diabetes. 1995;44:947-53.
    • (1995) Diabetes , vol.44 , pp. 947-953
    • Miles, P.D.1    Levisetti, M.2    Reichart, D.3    Khoursheed, M.4    Moossa, A.R.5    Olefsky, J.M.6
  • 17
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose and lipid metabolism
    • 11742412 10.1038/414799a 1:CAS:528:DC%2BD38Xhtlylsg%3D%3D
    • Saltiel AR, Kahn CR. Insulin signaling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 18
    • 0032987220 scopus 로고    scopus 로고
    • Insulin signaling: Metabolic pathways and mechanisms for specificity
    • 10433517 10.1016/S0898-6568(99)00025-X 1:CAS:528:DyaK1MXkt1ems78%3D
    • Nystrom FH, Quon MJ. Insulin signaling: metabolic pathways and mechanisms for specificity. Cell Signal. 1999;11:563-74.
    • (1999) Cell Signal , vol.11 , pp. 563-574
    • Nystrom, F.H.1    Quon, M.J.2
  • 19
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signaling pathways: Insights into insulin action
    • 16493415 10.1038/nrm1837 1:CAS:528:DC%2BD28XhtlWnsLw%3D
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signaling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006;7:85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 20
    • 84862543951 scopus 로고    scopus 로고
    • From signal transduction to signal interpretation: An alternative model for the molecular function of insulin receptor substrates
    • 22515179 10.3109/13813455.2012.671333 1:CAS:528:DC%2BC38Xoslaltbo%3D
    • Boller S, Joblin BA, Xu L, Item F, Trüb T, Boschetti N, et al. From signal transduction to signal interpretation: an alternative model for the molecular function of insulin receptor substrates. Arch Physiol Biochem. 2012;118(3):148-55.
    • (2012) Arch Physiol Biochem , vol.118 , Issue.3 , pp. 148-155
    • Boller, S.1    Joblin, B.A.2    Xu, L.3    Item, F.4    Trüb, T.5    Boschetti, N.6
  • 21
    • 0032523085 scopus 로고    scopus 로고
    • Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
    • 9541510 10.1172/JCI1594 1:CAS:528:DyaK1cXisV2qsbs%3D
    • Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, et al. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest. 1998;101:1784-8.
    • (1998) J Clin Invest , vol.101 , pp. 1784-1788
    • Abe, H.1    Yamada, N.2    Kamata, K.3    Kuwaki, T.4    Shimada, M.5    Osuga, J.6
  • 22
    • 0037662849 scopus 로고    scopus 로고
    • Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury
    • 12810606 10.1161/01.CIR.0000070937.52035.25 1:CAS:528: DC%2BD3sXksF2ntbc%3D
    • Kubota T, Kubota N, Moroi M, Terauchi Y, Kobayashi T, Kamata K, et al. Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation. 2003;107:3073-80.
    • (2003) Circulation , vol.107 , pp. 3073-3080
    • Kubota, T.1    Kubota, N.2    Moroi, M.3    Terauchi, Y.4    Kobayashi, T.5    Kamata, K.6
  • 23
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • 10376603 10.1038/21224 1:CAS:528:DyaK1MXjvFegu7s%3D
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601-5.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 24
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • 10747347 10.1161/01.CIR.101.13.1539 1:CAS:528:DC%2BD3cXivVyhtr4%3D
    • Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101:1539-45.
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.N.4    Kirby, M.5    Mostowski, H.6
  • 25
    • 0035839532 scopus 로고    scopus 로고
    • 2+ but requires phosphorylation byAkt at Ser(1179)
    • 11402048 10.1074/jbc.M103702200 1:CAS:528:DC%2BD3MXmtFehtLc%3D
    • 2+ but requires phosphorylation byAkt at Ser(1179). J Biol Chem. 2001;276:30392-8.
    • (2001) J Biol Chem , vol.276 , pp. 30392-30398
    • Montagnani, M.1    Chen, H.2    Barr, V.A.3    Quon, M.J.4
  • 26
    • 0037216768 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
    • 1:CAS:528:DC%2BD3sXmvF2gsg%3D%3D
    • Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physio. 2003;284:R1-12.
    • (2003) Am J Physiol Regul Integr Comp Physio , vol.284 , pp. 1-12
    • Fleming, I.1    Busse, R.2
  • 27
    • 33845742185 scopus 로고    scopus 로고
    • Mechanisms of disease: Endothelial dysfunction in insulin resistance and diabetes
    • 17179929 10.1038/ncpendmet0366 1:CAS:528:DC%2BD2sXmsVSksA%3D%3D
    • Rask-Madsen C, King GL. Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007;3:46-56.
    • (2007) Nat Clin Pract Endocrinol Metab. , vol.3 , pp. 46-56
    • Rask-Madsen, C.1    King, G.L.2
  • 28
    • 23744511665 scopus 로고    scopus 로고
    • Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
    • 1:CAS:528:DC%2BD2MXotFejsrg%3D
    • Potenza MA, Marasciulo FL, Chieppa DM, Brigiani GS, Formoso G, Quon MJ, et al. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol. 2005;289:H813-22.
    • (2005) Am J Physiol , vol.289 , pp. 813-822
    • Potenza, M.A.1    Marasciulo, F.L.2    Chieppa, D.M.3    Brigiani, G.S.4    Formoso, G.5    Quon, M.J.6
  • 29
    • 69049094056 scopus 로고    scopus 로고
    • Vascular actions of insulin with implications for endothelial dysfunction
    • 19491294 10.1152/ajpendo.00297.2009 1:CAS:528:DC%2BD1MXht1ykur7I
    • Potenza MA, Addabbo F, Montagnani M. Vascular actions of insulin with implications for endothelial dysfunction. Am J Physiol Endocrinol Metab. 2009;297:E568-77.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. 568-577
    • Potenza, M.A.1    Addabbo, F.2    Montagnani, M.3
  • 30
    • 0027953703 scopus 로고
    • Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes
    • 8039601 10.2337/diabetes.43.4.587 1:CAS:528:DyaK2cXlsFCht78%3D
    • Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes. 1994;43:1066-84.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 31
    • 84865428817 scopus 로고    scopus 로고
    • Pathophysiological roles of endothelin receptors in cardiovascular diseases
    • 22863667 10.1254/jphs.12R01CR 1:CAS:528:DC%2BC38XhtlagtbrM
    • Ohkita M, Tawa M, Kitada K, Matsumura Y. Pathophysiological roles of endothelin receptors in cardiovascular diseases. J Pharmacol Sci. 2012;119(4):302-13.
    • (2012) J Pharmacol Sci , vol.119 , Issue.4 , pp. 302-313
    • Ohkita, M.1    Tawa, M.2    Kitada, K.3    Matsumura, Y.4
  • 32
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • 16618833 10.1161/CIRCULATIONAHA.105.563213
    • Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-904.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 33
    • 0035116150 scopus 로고    scopus 로고
    • Diabetes and endothelial dysfunction: A clinical perspective
    • 11159815 10.1210/er.22.1.36 1:STN:280:DC%2BD3M3isFCktA%3D%3D
    • Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001;22:36-52.
    • (2001) Endocr Rev , vol.22 , pp. 36-52
    • Calles-Escandon, J.1    Cipolla, M.2
  • 34
    • 34447639114 scopus 로고    scopus 로고
    • Endothelial dysfunction in insulin resistance and type 2 diabetes
    • 17645585 10.1111/j.1365-2796.2007.01830.x 1:CAS:528:DC%2BD2sXhtVens7nP
    • Jansson PA. Endothelial dysfunction in insulin resistance and type 2 diabetes. J Intern Med. 2007;262:173-83.
    • (2007) J Intern Med. , vol.262 , pp. 173-183
    • Jansson, P.A.1
  • 35
    • 33644781862 scopus 로고    scopus 로고
    • Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    • 16505232 10.2337/diabetes.55.03.06.db05-0771 1:CAS:528: DC%2BD28XisVWis7s%3D
    • Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, et al. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006;55:691-8.
    • (2006) Diabetes , vol.55 , pp. 691-698
    • Naruse, K.1    Rask-Madsen, C.2    Takahara, N.3    Ha, S.W.4    Suzuma, K.5    Way, K.J.6
  • 36
    • 0032719024 scopus 로고    scopus 로고
    • Characterization of selective resistance to insulin signaling in the vasculature ofobese Zucker (fa/fa) rats
    • 10449437 10.1172/JCI5971 1:CAS:528:DyaK1MXltlekurw%3D
    • Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, et al. Characterization of selective resistance to insulin signaling in the vasculature ofobese Zucker (fa/fa) rats. J Clin Invest. 1999;104:447-57.
    • (1999) J Clin Invest , vol.104 , pp. 447-457
    • Jiang, Z.Y.1    Lin, Y.W.2    Clemont, A.3    Feener, E.P.4    Hein, K.D.5    Igarashi, M.6
  • 37
    • 70349648329 scopus 로고    scopus 로고
    • Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: The role of endothelin-1
    • 19581418 10.2337/db08-0961 1:CAS:528:DC%2BD1MXht1yku7jO
    • Gogg S, Smith U, Jansson PA. Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. Diabetes. 2009;58:2238-45.
    • (2009) Diabetes , vol.58 , pp. 2238-2245
    • Gogg, S.1    Smith, U.2    Jansson, P.A.3
  • 38
    • 79952142784 scopus 로고    scopus 로고
    • Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
    • 21356519 10.1016/j.cmet.2011.01.018 1:CAS:528:DC%2BC3MXisFGrsro%3D
    • Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, et al. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab. 2011;13:294-307.
    • (2011) Cell Metab. , vol.13 , pp. 294-307
    • Kubota, T.1    Kubota, N.2    Kumagai, H.3    Yamaguchi, S.4    Kozono, H.5    Takahashi, T.6
  • 39
    • 0035957414 scopus 로고    scopus 로고
    • Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes
    • 11259670 10.1073/pnas.071054598 1:CAS:528:DC%2BD3MXis1Kiu7s%3D
    • Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci USA. 2001;98:3756-61.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3756-3761
    • Zhang, J.1    Ou, J.2    Bashmakov, Y.3    Horton, J.D.4    Brown, M.S.5    Goldstein, J.L.6
  • 40
    • 2342483040 scopus 로고    scopus 로고
    • SREBPs suppress IRS-2-mediated insulin signaling in the liver
    • 15048126 10.1038/ncb1111 1:CAS:528:DC%2BD2cXis1GltLg%3D
    • Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, et al. SREBPs suppress IRS-2-mediated insulin signaling in the liver. Nat Cell Biol. 2004;6:351-7.
    • (2004) Nat Cell Biol. , vol.6 , pp. 351-357
    • Ide, T.1    Shimano, H.2    Yahagi, N.3    Matsuzaka, T.4    Nakakuki, M.5    Yamamoto, T.6
  • 42
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • 382871 1:CAS:528:DyaE1MXlslWhs70%3D
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214-23.
    • (1979) Am J Physiol , vol.237 , pp. 214-223
    • Defronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 43
    • 42449107752 scopus 로고    scopus 로고
    • Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
    • 18223011 10.2337/db07-1444 1:CAS:528:DC%2BD1cXksVGktb8%3D
    • Chiu JD, Richey JM, Harrison LN, Zuniga E, Kolka CM, Kirkman E, et al. Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal. Diabetes. 2008;57:828-35.
    • (2008) Diabetes , vol.57 , pp. 828-835
    • Chiu, J.D.1    Richey, J.M.2    Harrison, L.N.3    Zuniga, E.4    Kolka, C.M.5    Kirkman, E.6
  • 44
    • 0022500793 scopus 로고
    • In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
    • 3525609 10.1172/JCI112599 1:CAS:528:DyaL28XltV2jtb8%3D
    • Prager R, Wallace P, Olefsky JM. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest. 1986;78:472-81.
    • (1986) J Clin Invest , vol.78 , pp. 472-481
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 45
    • 0028847791 scopus 로고
    • The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
    • 7860757 10.1172/JCI117723 1:CAS:528:DyaK2MXjsV2rs7Y%3D
    • Turk D, Alzaid A, Dinneen S, Nair KS, Rizza R. The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues. J Clin Invest. 1995;95:755-62.
    • (1995) J Clin Invest , vol.95 , pp. 755-762
    • Turk, D.1    Alzaid, A.2    Dinneen, S.3    Nair, K.S.4    Rizza, R.5
  • 46
    • 0036723832 scopus 로고    scopus 로고
    • Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects
    • 12196467 10.2337/diabetes.51.9.2742
    • Sjöstrand M, Gudbjörnsdottir S, Holmäng A, Lönn L, Strindberg L, Lönnroth P. Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects. Diabetes. 2002;51:2742-8.
    • (2002) Diabetes , vol.51 , pp. 2742-2748
    • Sjöstrand, M.1    Gudbjörnsdottir, S.2    Holmäng, A.3    Lönn, L.4    Strindberg, L.5    Lönnroth, P.6
  • 47
    • 33846798106 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms
    • 17272818 10.1161/01.RES.0000255691.76142.4a 1:CAS:528: DC%2BD2sXhtVOruro%3D
    • Aird WC. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res. 2007;100:158-73.
    • (2007) Circ Res , vol.100 , pp. 158-173
    • Aird, W.C.1
  • 48
    • 0021907605 scopus 로고
    • Receptor-mediated transport of insulin across endothelial cells
    • 3883490 10.1126/science.3883490 1:CAS:528:DyaL2MXhs1Srtb4%3D
    • King GL, Johnson SM. Receptor-mediated transport of insulin across endothelial cells. Science. 1985;227:1583-6.
    • (1985) Science , vol.227 , pp. 1583-1586
    • King, G.L.1    Johnson, S.M.2
  • 49
    • 0022019629 scopus 로고
    • Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture
    • 3881990 1:CAS:528:DyaL2MXht1KjsrY%3D
    • Dernovsek KD, Bar RS. Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture. Am J Physiol. 1985;248:E244-51.
    • (1985) Am J Physiol , vol.248 , pp. 244-251
    • Dernovsek, K.D.1    Bar, R.S.2
  • 50
    • 0027997787 scopus 로고
    • Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules
    • 7525606 10.1083/jcb.127.5.1217 1:CAS:528:DyaK2cXmslOnu7Y%3D
    • Schnitzer JE, Oh P, Pinney E, Allard J. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol. 1994;127:1217-32.
    • (1994) J Cell Biol. , vol.127 , pp. 1217-1232
    • Schnitzer, J.E.1    Oh, P.2    Pinney, E.3    Allard, J.4
  • 51
    • 0029871377 scopus 로고    scopus 로고
    • Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process
    • 8617883 10.1172/JCI118572 1:CAS:528:DyaK28XhvVensbc%3D
    • Steil GM, Ader M, Moore DM, Rebrin K, Bergman RN. Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. J Clin Invest. 1996;97:1497-503.
    • (1996) J Clin Invest , vol.97 , pp. 1497-1503
    • Steil, G.M.1    Ader, M.2    Moore, D.M.3    Rebrin, K.4    Bergman, R.N.5
  • 52
    • 0036314289 scopus 로고    scopus 로고
    • Mode of transcapillary transport of insulin and insulin analog NN304in dog hindlimb: Evidence for passive diffusion
    • 11872653 10.2337/diabetes.51.3.574 1:CAS:528:DC%2BD38XitFSgsrY%3D
    • Hamilton-Wessler M, Ader M, Dea MK, Moore D, Loftager M, Markussen J, et al. Mode of transcapillary transport of insulin and insulin analog NN304in dog hindlimb: evidence for passive diffusion. Diabetes. 2002;51:574-82.
    • (2002) Diabetes , vol.51 , pp. 574-582
    • Hamilton-Wessler, M.1    Ader, M.2    Dea, M.K.3    Moore, D.4    Loftager, M.5    Markussen, J.6
  • 53
    • 84856734904 scopus 로고    scopus 로고
    • Insulin entry into muscle involves a saturable process in the vascular endothelium
    • 22002008 10.1007/s00125-011-2343-x 1:CAS:528:DC%2BC3MXhs1ynur7E
    • Majumdar S, Genders AJ, Inyard AC, Frison V, Barrett EJ. Insulin entry into muscle involves a saturable process in the vascular endothelium. Diabetologia. 2012;55:450-6.
    • (2012) Diabetologia , vol.55 , pp. 450-456
    • Majumdar, S.1    Genders, A.J.2    Inyard, A.C.3    Frison, V.4    Barrett, E.J.5
  • 54
    • 79960768692 scopus 로고    scopus 로고
    • Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
    • 10.1152/ajpendo.00186.2011 1:CAS:528:DC%2BC3MXhtFSqurvF
    • Barrett EJ, Wang H, Upchurch CT, Liu Z. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am J Physiol Endocrinol Metab. 2011;30:E252-63.
    • (2011) Am J Physiol Endocrinol Metab , vol.30 , pp. 252-263
    • Barrett, E.J.1    Wang, H.2    Upchurch, C.T.3    Liu, Z.4
  • 55
    • 33745865888 scopus 로고    scopus 로고
    • The vascular endothelial cell mediates insulin transport into skeletal muscle
    • 16569759 10.1152/ajpendo.00047.2006 1:CAS:528:DC%2BD28XovVWgt7s%3D
    • Wang H, Liu Z, Li G, Barrett EJ. The vascular endothelial cell mediates insulin transport into skeletal muscle. Am J Physiol Endocrinol Metab. 2006;291:E323-32.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. 323-332
    • Wang, H.1    Liu, Z.2    Li, G.3    Barrett, E.J.4
  • 56
    • 78650767327 scopus 로고    scopus 로고
    • Caveolin-1 is required for vascular endothelial insulin uptake
    • 20959538 10.1152/ajpendo.00498.2010 1:CAS:528:DC%2BC3MXhvVSjsLg%3D
    • Wang H, Wang AX, Barrett EJ. Caveolin-1 is required for vascular endothelial insulin uptake. Am J Physiol Endocrinol Metab. 2011;300:E134-44.
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. 134-144
    • Wang, H.1    Wang, A.X.2    Barrett, E.J.3
  • 57
    • 0037131313 scopus 로고    scopus 로고
    • Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice
    • 12167625 10.1074/jbc.M205948200 1:CAS:528:DC%2BD38XnvVehtrs%3D
    • Schubert W, Frank PG, Woodman SE, Hyogo H, Cohen DE, Chow CW, et al. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem. 2002;277:40091-8.
    • (2002) J Biol Chem , vol.277 , pp. 40091-40098
    • Schubert, W.1    Frank, P.G.2    Woodman, S.E.3    Hyogo, H.4    Cohen, D.E.5    Chow, C.W.6
  • 58
    • 0030863236 scopus 로고    scopus 로고
    • Hemodynamic actions of insulin in rat skeletal muscle: Evidence for capillary recruitment
    • 9287035 10.2337/diabetes.46.9.1381 1:CAS:528:DyaK2sXlvFenur4%3D
    • Rattigan S, Clark MG, Barrett EJ. Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. Diabetes. 1997;46:1381-8.
    • (1997) Diabetes , vol.46 , pp. 1381-1388
    • Rattigan, S.1    Clark, M.G.2    Barrett, E.J.3
  • 59
    • 0022502428 scopus 로고
    • Xanthine oxidase: Biochemistry, distribution and physiology
    • 3529824 1:CAS:528:DyaL28XkslKktbw%3D
    • Parks DA, Granger DN. Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol Scand Suppl. 1986;548:87-99.
    • (1986) Acta Physiol Scand Suppl. , vol.548 , pp. 87-99
    • Parks, D.A.1    Granger, D.N.2
  • 60
    • 0032501992 scopus 로고    scopus 로고
    • Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion
    • 9490243 10.1161/01.CIR.97.5.473 1:STN:280:DyaK1c7ktVKrtw%3D%3D
    • Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998;97:473-83.
    • (1998) Circulation , vol.97 , pp. 473-483
    • Wei, K.1    Jayaweera, A.R.2    Firoozan, S.3    Linka, A.4    Skyba, D.M.5    Kaul, S.6
  • 61
    • 56049106597 scopus 로고    scopus 로고
    • Impaired microvascular perfusion: A consequence of vascular dysfunction and a potential cause of insulin resistance in muscle
    • 18612041 10.1152/ajpendo.90477.2008 1:CAS:528:DC%2BD1cXht1ymtb7L
    • Clark MG. Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle. Am J Physiol Endocrinol Metab. 2008;295:E732-50.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. 732-750
    • Clark, M.G.1
  • 62
    • 64149117276 scopus 로고    scopus 로고
    • The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
    • 19283361 10.1007/s00125-009-1313-z 1:CAS:528:DC%2BD1MXktVOktbY%3D
    • Barrett EJ, Eggleston EM, Inyard AC, Wang H, Li G, Chai W, et al. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia. 2009;52:752-64.
    • (2009) Diabetologia , vol.52 , pp. 752-764
    • Barrett, E.J.1    Eggleston, E.M.2    Inyard, A.C.3    Wang, H.4    Li, G.5    Chai, W.6
  • 63
    • 0036097592 scopus 로고    scopus 로고
    • Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow
    • 11756321 10.2337/diabetes.51.1.42 1:CAS:528:DC%2BD38Xlt1ejtQ%3D%3D
    • Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, et al. Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes. 2002;51:42-8.
    • (2002) Diabetes , vol.51 , pp. 42-48
    • Vincent, M.A.1    Dawson, D.2    Clark, A.D.3    Lindner, J.R.4    Rattigan, S.5    Clark, M.G.6
  • 64
    • 0035902547 scopus 로고    scopus 로고
    • Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase
    • 11457755 10.1161/01.CIR.104.3.342 1:CAS:528:DC%2BD3MXlslOmtLg%3D
    • Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, et al. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation. 2001;104:342-5.
    • (2001) Circulation , vol.104 , pp. 342-345
    • Duplain, H.1    Burcelin, R.2    Sartori, C.3    Cook, S.4    Egli, M.5    Lepori, M.6
  • 65
    • 0037663840 scopus 로고    scopus 로고
    • Inhibiting NOS blocks microvascular recruitment and blunts glucose uptake in response to insulin
    • 12791603 1:CAS:528:DC%2BD3sXls1Wnu74%3D
    • Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S. Inhibiting NOS blocks microvascular recruitment and blunts glucose uptake in response to insulin. Am J Physiol Endocrinol Metab. 2003;285:E123-9.
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. 123-129
    • Vincent, M.A.1    Barrett, E.J.2    Lindner, J.R.3    Clark, M.G.4    Rattigan, S.5
  • 66
    • 0028113927 scopus 로고
    • Nitric oxide release accounts for insulin's vascular effects in humans
    • 7989610 10.1172/JCI117621 1:CAS:528:DyaK2MXisFWgsrY%3D
    • Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 1994;94:2511-5.
    • (1994) J Clin Invest , vol.94 , pp. 2511-2515
    • Scherrer, U.1    Randin, D.2    Vollenweider, P.3    Vollenweider, L.4    Nicod, P.5
  • 67
    • 33947228451 scopus 로고    scopus 로고
    • Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells
    • 17242212 10.1128/MCB.01340-06 1:CAS:528:DC%2BD2sXjsVSrt7c%3D
    • Andreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, et al. Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol. 2007;27:2372-83.
    • (2007) Mol Cell Biol , vol.27 , pp. 2372-2383
    • Andreozzi, F.1    Laratta, E.2    Procopio, C.3    Hribal, M.L.4    Sciacqua, A.5    Perticone, M.6
  • 68
    • 9144222572 scopus 로고    scopus 로고
    • G972RIRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    • 14707024 10.1161/01.CIR.0000109498.77895.6F 1:CAS:528: DC%2BD2cXks1CisA%3D%3D
    • Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D, et al. G972RIRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation. 2004;109:399-405.
    • (2004) Circulation , vol.109 , pp. 399-405
    • Federici, M.1    Pandolfi, A.2    De Filippis, E.A.3    Pellegrini, G.4    Menghini, R.5    Lauro, D.6
  • 69
    • 0025959815 scopus 로고
    • Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level
    • 1706920 10.1016/0006-2952(91)90651-K 1:CAS:528:DyaK3MXisVWhtro%3D
    • Kainoh M, Maruyama I, Nishio S, Nakadate T. Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level. Biochem Pharmacol. 1991;41:1135-40.
    • (1991) Biochem Pharmacol , vol.41 , pp. 1135-1140
    • Kainoh, M.1    Maruyama, I.2    Nishio, S.3    Nakadate, T.4
  • 70
    • 0141831989 scopus 로고    scopus 로고
    • Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: Close link between PGI2 signal and NO pathways
    • 12919953 10.1161/01.RES.0000091336.55487.F7 1:CAS:528: DC%2BD3sXntFCmt7Y%3D
    • Niwano K, Arai M, Tomaru K, Uchiyama T, Ohyama Y, Kurabayashi M. Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways. Circ Res. 2003;93:523-30.
    • (2003) Circ Res , vol.93 , pp. 523-530
    • Niwano, K.1    Arai, M.2    Tomaru, K.3    Uchiyama, T.4    Ohyama, Y.5    Kurabayashi, M.6
  • 71
    • 0034713816 scopus 로고    scopus 로고
    • Oral Beraprost sodium, a prostaglandin I2 analogue, for intermittent claudication: A double-blind, randomized, multicenter controlled trial. Beraprostet Claudication Intermittente (BERCI) Research Group
    • 10908215 10.1161/01.CIR.102.4.426
    • Lièvre M, Morand S, Besse B, Fiessinger J, Boissel J. Oral Beraprost sodium, a prostaglandin I2 analogue, for intermittent claudication: a double-blind, randomized, multicenter controlled trial. Beraprostet Claudication Intermittente (BERCI) Research Group. Circulation. 2000;102:426-31.
    • (2000) Circulation , vol.102 , pp. 426-431
    • Lièvre, M.1    Morand, S.2    Besse, B.3    Fiessinger, J.4    Boissel, J.5
  • 72
    • 0036569119 scopus 로고    scopus 로고
    • Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) study group effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial
    • 11985913 10.1016/S0735-1097(02)01786-2
    • Galiè N, Humbert M, Vachiéry JL, Vizza CD, Kneussl M, Manes A, et al. Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) study group effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol. 2002;39:1496-502.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galiè, N.1    Humbert, M.2    Vachiéry, J.L.3    Vizza, C.D.4    Kneussl, M.5    Manes, A.6
  • 73
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • 19444259 10.1038/nrendo.2009.48 1:CAS:528:DC%2BD1MXlvV2ktbw%3D
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:262-9.
    • (2009) Nat Rev Endocrinol. , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 74
    • 0027495779 scopus 로고
    • GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery
    • 8238371 1:CAS:528:DyaK2cXitl2ksw%3D%3D
    • Richter G, Feddersen O, Wagner U, Barth P, Göke R, Göke B. GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery. Am J Physiol. 1993;265:L374-81.
    • (1993) Am J Physiol , vol.265 , pp. 374-381
    • Richter, G.1    Feddersen, O.2    Wagner, U.3    Barth, P.4    Göke, R.5    Göke, B.6
  • 75
    • 8544258807 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    • 15353407 10.1152/ajpendo.00237.2004 1:CAS:528:DC%2BD2cXhtFShsLvJ
    • Nyström T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrén B, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab. 2004;287:E1209-15.
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. 1209-1215
    • Nyström, T.1    Gutniak, M.K.2    Zhang, Q.3    Zhang, F.4    Holst, J.J.5    Ahrén, B.6
  • 76
    • 77954384449 scopus 로고    scopus 로고
    • Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor
    • 20452396 10.1016/j.mce.2010.04.022 1:CAS:528:DC%2BC3cXos1ykurY%3D
    • Erdogdu O, Nathanson D, Sjöholm A, Nyström T, Zhang Q. Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor. Mol Cell Endocrinol. 2010;325:26-35.
    • (2010) Mol Cell Endocrinol , vol.325 , pp. 26-35
    • Erdogdu, O.1    Nathanson, D.2    Sjöholm, A.3    Nyström, T.4    Zhang, Q.5
  • 77
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • 22357961 10.2337/db11-1073 1:CAS:528:DC%2BC38XkslCht7w%3D
    • Chai W, Dong Z, Wang N, Wang W, Tao L, Cao W, et al. Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes. 2012;61:888-96.
    • (2012) Diabetes , vol.61 , pp. 888-896
    • Chai, W.1    Dong, Z.2    Wang, N.3    Wang, W.4    Tao, L.5    Cao, W.6
  • 78
    • 0036224228 scopus 로고    scopus 로고
    • Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo
    • 11916937 10.2337/diabetes.51.4.1138 1:CAS:528:DC%2BD38Xis1Oisrw%3D
    • Clerk LH, Rattigan S, Clark MG. Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes. 2002;51:1138-45.
    • (2002) Diabetes , vol.51 , pp. 1138-1145
    • Clerk, L.H.1    Rattigan, S.2    Clark, M.G.3
  • 79
    • 0033761684 scopus 로고    scopus 로고
    • Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha
    • 11078458 10.2337/diabetes.49.11.1904 1:CAS:528:DC%2BD3cXnvVOmt7c%3D
    • Youd JM, Rattigan S, Clark MG. Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha. Diabetes. 2000;49:1904-9.
    • (2000) Diabetes , vol.49 , pp. 1904-1909
    • Youd, J.M.1    Rattigan, S.2    Clark, M.G.3
  • 81
    • 26244456737 scopus 로고    scopus 로고
    • Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment
    • 16059714 10.1007/s00125-005-1887-z 1:CAS:528:DC%2BD2MXhtVyltLnK
    • Wallis MG, Smith ME, Kolka CM, Zhang L, Richards SM, Rattigan S, et al. Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment. Diabetologia. 2005;48:2131-9.
    • (2005) Diabetologia , vol.48 , pp. 2131-2139
    • Wallis, M.G.1    Smith, M.E.2    Kolka, C.M.3    Zhang, L.4    Richards, S.M.5    Rattigan, S.6
  • 82
    • 0036897102 scopus 로고    scopus 로고
    • Insulin-mediated hemodynamic changes are impaired in muscle of zucker obese rats
    • 12453905 10.2337/diabetes.51.12.3492 1:CAS:528:DC%2BD38Xptl2nu78%3D
    • Wallis MG, Wheatley CM, Rattigan S, Barrett EJ, Clark AD, Clark MG. Insulin-mediated hemodynamic changes are impaired in muscle of zucker obese rats. Diabetes. 2002;51:3492-8.
    • (2002) Diabetes , vol.51 , pp. 3492-3498
    • Wallis, M.G.1    Wheatley, C.M.2    Rattigan, S.3    Barrett, E.J.4    Clark, A.D.5    Clark, M.G.6
  • 83
    • 0028123578 scopus 로고
    • Reduced microvascular hyperaemia in subjects at risk of developing type 2(non-insulin-dependent) diabetes mellitus
    • 8163058 10.1007/s001250050096 1:STN:280:DyaK2c3hsFOnuw%3D%3D
    • Jaap AJ, Hammersley MS, Shore AC, Tooke JE. Reduced microvascular hyperaemia in subjects at risk of developing type 2(non-insulin-dependent) diabetes mellitus. Diabetologia. 1994;37:214-6.
    • (1994) Diabetologia , vol.37 , pp. 214-216
    • Jaap, A.J.1    Hammersley, M.S.2    Shore, A.C.3    Tooke, J.E.4
  • 84
    • 0032878326 scopus 로고    scopus 로고
    • Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2diabetes
    • 10480619 10.2337/diabetes.48.9.1856 1:CAS:528:DyaK1MXmtVaitbg%3D
    • Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, et al. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2diabetes. Diabetes. 1999;48:1856-62.
    • (1999) Diabetes , vol.48 , pp. 1856-1862
    • Caballero, A.E.1    Arora, S.2    Saouaf, R.3    Lim, S.C.4    Smakowski, P.5    Park, J.Y.6
  • 85
    • 39049183894 scopus 로고    scopus 로고
    • Microvascular dysfunction: Causative role in the association between hypertension, insulin resistance and the metabolic syndrome
    • 17144887 10.1042/bse0420163
    • Serné EH, de Jongh RT, Eringa EC, Ijzerman RG, de Boer MP, Stehouwer CD. Microvascular dysfunction: causative role in the association between hypertension, insulin resistance and the metabolic syndrome. Essays Biochem. 2006;42:163-76.
    • (2006) Essays Biochem. , vol.42 , pp. 163-176
    • Serné, E.H.1    De Jongh, R.T.2    Eringa, E.C.3    Ijzerman, R.G.4    De Boer, M.P.5    Stehouwer, C.D.6
  • 86
    • 14044250985 scopus 로고    scopus 로고
    • Decreased muscle capillary permeability surface area in type 2diabetic subjects
    • 15536160 10.1210/jc.2004-0947 1:CAS:528:DC%2BD2MXhsVCgtLs%3D
    • Gudbjörnsdóttir S, Sjöstrand M, Strindberg L, Lönnroth P. Decreased muscle capillary permeability surface area in type 2diabetic subjects. J Clin Endocrinol Metab. 2005;90:1078-82.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1078-1082
    • Gudbjörnsdóttir, S.1    Sjöstrand, M.2    Strindberg, L.3    Lönnroth, P.4
  • 87
    • 0141992797 scopus 로고    scopus 로고
    • The discovery of tadalafil: A novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues
    • 14521414 10.1021/jm030056e 1:CAS:528:DC%2BD3sXnvVCju78%3D
    • Daugan A, Grondin P, Ruault C, de Gouville AC LM, Coste H, Linget JM, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues. J Med Chem. 2003;46:4525-32.
    • (2003) J Med Chem , vol.46 , pp. 4525-4532
    • Daugan, A.1    Grondin, P.2    Ruault, C.3    De Gouville Ac, L.M.4    Coste, H.5    Linget, J.M.6
  • 88
    • 77958033082 scopus 로고    scopus 로고
    • Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes
    • 20535445 10.1007/s00125-010-1819-4 1:CAS:528:DC%2BC3cXhtV2gtrnP
    • Jansson PA, Murdolo G, Sjögren L, Nyström B, Sjöstrand M, Strindberg L, et al. Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes. Diabetologia. 2010;53:2205-8. Technology Technology Technology Technology Technology
    • (2010) Diabetologia , vol.53 , pp. 2205-2208
    • Jansson, P.A.1    Murdolo, G.2    Sjögren, L.3    Nyström, B.4    Sjöstrand, M.5    Strindberg, L.6


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