Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes

Diabetologia

Volumn 53, Issue 10, 2010, Pages 2205-2208

  Jansso, P A ^a   Murdolo, G ^b   Sjogren L ^a   Nystrom B ^c   Sjostrand M ^a   Strindberg, L ^a   Lonnroth P ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Endothelial dysfunction; Glucose lowering drugs; Insulin resistance; Microdialysis; Phosphodiesterase 5

Indexed keywords

GLUCOSE; INSULIN; PLACEBO; TADALAFIL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MICRODIALYSIS; MUSCLE BLOOD FLOW; MUSCLE CAPILLARY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

AGED; AREA UNDER CURVE; CAPILLARIES; CARBOLINES; DIABETES MELLITUS, TYPE 2; FEMALE; FOREARM; GLUCOSE; HUMANS; LINEAR MODELS; MICRODIALYSIS; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; REGIONAL BLOOD FLOW;

EID: 77958033082     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1819-4     Document Type: Article

References (11)

1. Jaap AJ, Hammersley MS, Shore AC, Tooke JE (1994) Reduced microvascular hyperaemia in subjects at risk of developing type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 37: 214-216
2. Caballero AE, Arora S, Saouaf R et al (1999) Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48:1856-1862
3. Serné EH, de Jongh RT, Eringa EC, Ijzerman RG, de Boer MP, Stehouwer CD (2006) Microvascular dysfunction: causative role in the association between hypertension, insulin resistance and the metabolic syndrome. Essays Biochem 42:163-176
4. Mahajan H, Kolka CM, Newman J, Rattigan S, Richards SM, Clark M (2006) Vascular and metabolic effects of methacholine in relation to insulin action in muscle. Diabetologia 49:713-723
5. Murdolo G, Sjöstrand M, Strindberg L et al (2008) Effects of intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals. J Clin Endocrinol Metab 93:2764-2773
6. Gudbjörnsdóttir S, Sjöstrand M, Strindberg L, Lönnroth P (2005) Decreased muscle capillary permeability surface area in type 2 diabetic subjects. J Clin Endocrinol Metab 90:1078-1082
7. Crone C, Levitt D (1984) Capillary permeability to small solutes. In: Renkin E, Michel C, Geiger S (eds) Handbook of physiology. The cardiovascular system. Microcirculation. American Physiological Society, Maryland, pp 411-166
8. Ayala J, Bracy D, Julien B, Rottman J, Fueger P, Wasserman D (2007) Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 56:1025-1033
9. Hill KD, Eckhauser AW, Marney A, Brown NJ (2009) Phosphodiesterase 5 inhibition improves beta cell function in the metabolic syndrome. Diab Care 32:857-859
10. Coggins M, Lindner J, Rattigan S et al (2001) Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes 50:2682-2690
11. Carson CC, Rajfer J, Eardley I et al (2004) The efficacy and safety of tadalafil: an update. BJU Int 93:1276-1281