Microvascular dysfunction: Causative role in the association between hypertension, insulin resistance and the metabolic syndrome?

Essays in Biochemistry

Volumn 42, Issue , 2006, Pages 163-176

  Serné, Erik H ^a   DeJongh, Renate T ^a   Eringa, Etto C ^a   Ijzerman, Richard G ^a   DeBoer, Michiel P ^a   Stehouwer, Coen D A ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; CAPILLARY PERMEABILITY; ENDOCRINE GLAND; HUMAN; HYPERTENSION; INSULIN RESISTANCE; METABOLIC SYNDROME X; MICROCIRCULATION; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

CAPILLARY PERMEABILITY; ENDOCRINE GLANDS; HUMANS; HYPERTENSION; INSULIN RESISTANCE; METABOLIC SYNDROME X; MICROCIRCULATION; MODELS, BIOLOGICAL; OBESITY; SIGNAL TRANSDUCTION;

EID: 39049183894     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/bse0420163     Document Type: Article

References (33)

1. Grundy, S.M., Brewer, Jr, H.B., Cleeman, J.I., Smith, Jr, S.C., & Lenfant, C. (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 109, 433-438
2. Serné, E.H., Stehouwer, C.D., ter Maaten, J.C., ter Wee, P.M., Rauwerda, J.A., Donker, A.J. & Gans, R.O. (1999) Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. Circulation. 99, 896-902
3. Levy, B.I., Ambrosio, G., Pries, A.R. & Struijker-Boudier, H.A. (2001) Microcirculation in hypertension: a new target for treatment? Circulation. 104, 736-741
4. Clark, M.G., Wallis, M.G., Barrett, E.J., Vincent, M.A., Richards, S.M., Clerk, LH. & Rattigan, S. (2003) Blood flow and muscle metabolism: a focus on insulin action. Am. J. Physiol. Endocrinol. Metob. 284, E241-E258
5. Serne, E.H., Gans, R.O., ter Maaten, J.C., Tangelder, G.J., Donker, A.J. & Stehouwer, CD. (2001) Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction. Hypertension. 38, 238-242
6. Serné, E.H., Gans, R.O., ter Maaten, J.C., ter Wee, P.M., Donker, A.J. & Stehouwer, C.D. (2001) Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. Cardiovasc Res. 49, 161-168
7. de Jongh, R.T., Serné, E.H., IJzerman, R.G., de Vries, G. & Stehouwer, CD. (2004) Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension and insulin resistance. Circulation. 109, 2529-2535
8. Hedman, A., Reneland, R. & Lithell, H.O. (2000) Alterations in skeletal muscle morphology in glucose-tolerant elderly hypertensive men: relationship to development of hypertension and heart rate. J. Hypertens. 18, 559-565
9. Wong, T.Y., Klein, R., Sharrett, A.R., Duncan, B.B., Couper, D.J., Klein, B.E., Hubbard, LD. & Nieto, F.J. (2004) Retinal arteriolar diameter and risk for hypertension. Ann. Intern. Med. 140, 248-255
10. Johnson, R.J., Herrera-Acosta, J., Schreiner, G.F. & Rodriguez-lturbe, B. (2002) Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N. Engl. J. Med. 346, 913-923
11. le Noble, F.A., Stassen, F.R., Hacking, W.J. & Struijker Boudier, H.A. (1998) Angiogenesis and hypertension. J. Hypertens. 16, 1563-1572
12. Galletti, F., Strazzullo, P., Ferrara, I., Annuzzi, G., Rivellese, A.A., Gatto, S. & Mancini, M. (1997) NaCI sensitivity of essential hypertensive patients is related to insulin resistance. J. Hypertens. 15, 1485-1491
13. Wright, D.L & Sonnenschein, R.R. (1965) Relations among activity, blood flow and vascular state in skeletal muscle. Am. J. Physiol. 208, 782-789
14. Ellis, C.G., Wrigley, S.M. & Groom, A.C. (1994) Heterogeneity of red blood cell perfusion in capillary networks supplied by a single arteriole in resting skeletal muscle. Circ Res. 75, 357-368
15. Shulman, G.I. (2004) Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy. Physiology. 19, 183-190
16. Serné, E.H., IJzerman, R.G., Gans, R.O., Nijveldt, R., de Vries, G., Evertz, R., Donker, A.J. & Stehouwer, C.D. (2002) Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. Diabetes. 51, 1515-1522
17. Vincent, M.A., Clerk, L.H., Rattigan, S., Clark, M.G. & Barrett, E.J. (2005) Active role for the vasculature in the delivery of insulin to skeletal muscle. Clin. Exp. Pharmacol. Physiol. 32, 302-307
18. de Jongh, R.T., Serné, E.H., IJzerman, R.G., de Vries, G. & Stehouwer, CD. (2004) Free fatty acid levels modulate microvascular function: relevance for obesityassociated insulin resistance, hypertension and microangiopathy. Diabetes. 53, 2873-2882
19. de Jongh, R.T., Clark, A.D., Ijzerman, R.G., Serne, E.H., de Vries, G. & Stehouwer, C.D. (2004) Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia. 47, 978-986
20. Gudbjornsdottir, S., Sjostrand, M., Strindberg, L & Lonnroth, P. (2005) Decreased muscle capilary permeability surface area in type 2 diabetic subjects. J. Clin. Endocrinol. Metab. 90, 1078-1082
21. Sjostrand, M., Gudbjornsdottir, S., Holmang, A., Lonn, L., Strindberg, L & Lonnroth, P. (2002) Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects. Diabetes. 51, 2742-2748
22. Eringa, E.C., Stehouwer, CD., Merlijn, T., Westerhof, N. & Sipkema, P. (2002) Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or P13-kinase in skeletal muscle arterioles. Cardiovasc. Res. 56, 464-471
23. Kim, J.A., Montagnani, M., Koh, K.K. & Quon, M.J. (2006) Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 113, 1888-1904
24. Eringa, E.C., Stehouwer, C.D., Nieuw Amerongen, G.P., Ouwehand, L., Westerhof, N. & Sipkema, P. (2004) Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am. J. Physiol. Heart Circ. Physiol. 287, H2043-H2048
25. Jiang, Z.Y., Lin, Y.W., Clemont, A., Feener, E.P., Hein, K.D., Igarashi, M., Yamauchi, T., White, M.F. & King, G.L. (1999) Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 104, 447-457
26. Potenza, M.A., Marasciulo, F.L., Chieppa, D.M., Brigiani, G.S., Formoso, G., Quon, M.J. & Montagnani, M. (2005) Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-I production. Am. J. Physiol. Heart Circ. Physiol. 289, H813-H822
27. Cardillo, C., Campia, U., lantorno, M. & Panza, J.A. (2004) Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension. 43, 36-40
28. Kelley, D.E., Williams, K.V. & Price, J.C. (1999) Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET. Am. J. Physiol. 277, E361-E369
29. IJzerman, R.G., Voordouw, J.J., van Weissenbruch, M.M., Yudkin, J.S., Serne, E.H., Delemarre-van de Waal, H.A. & Stehouwer, C.D. (2005) TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance. Clin. Sci. 110, 361-368
30. Pausova, Z., Deslauriers, B., Gaudet, D., Tremblay, J., Kotchen, T.A., Larochelle, P., Cowley, A.W. & Harriet, P. (2000) Role of tumor necrosis factor-α gene locus in obesity and obesity-associated hypertension in French Canadians. Hypertension. 36, 14-19
31. Eringa, E.C., Stehouwer, C.D., Walburg, K., Clark, A.D., Nieuw Amerongen, G.P., Westerhof, N. & Sipkema, P. (2006) Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-α dependence on c-Jun N-terminal kinase. Arterioscler. Thromb. Vasc. Biol. 26, 274-280
32. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C.Z., Uysal, K.T., Maeda, K., Karin, M. & Hotamisligil, G.S. (2002) A central role for JNK in obesity and insulin resistance. Nature. 420, 333-336
33. Yudkin, J.S., Eringa, E. & Stehouwer, C.D. (2005) "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet. 365, 1817-1820