Synthesis and anticonvulsant activity of novel quinazolin-4(3H)-one derived pyrazole analogs

Medicinal Chemistry Research

Volumn 22, Issue 4, 2013, Pages 1711-1722

  Alagarsamy, Veerachamy ^a   Saravanan, Govindaraj ^b  

^a MNR College of Pharmacy   (India)

^b BAPATLA COLLEGE OF PHARMACY   (India)

Author keywords

Epilepsy; In vivo studies; Neurotoxicity; Pyrazole; Quniazoline

Indexed keywords

2 METHYL 3 [4 (3 PHENYL 5 PARA TOLYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL)PHENYL]QUINAZOLIN 4 (3H)ONE; 2 METHYL 3 [4 [5 (3 NITROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL]QUINAZOLIN 4 (3H)ONE; 2 PHENYL 3 [4 (3 PHENYL 5 PARA TOLYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL)PHENYL]QUINAZOLIN 4 (3H)ONE; 3 [4 [5 (3 NITROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 PHENYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 CHLOROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 CHLOROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 PHENYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 HYDROXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 HYDROXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 PHENYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 METHOXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 (4 METHOXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 PHENYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 [4 (DIMETHYLAMINO)PHENYL] 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 3 [4 [5 [4 (DIMETHYLAMINO)PHENYL] 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 PHENYLQUINAZOLIN 4 (3H)ONE; 4 (2 METHYL 4 OXOQUINAZOLIN 3 (4H) YL)BENZOHYDRAZIDE; 4 (4 OXO 2 PHENYLQUINAZOLIN 3 (4H) YL)BENZOHYDRAZIDE; 4 (6,8 DIBROMO 2 METHYL 4 OXOQUINAZOLIN 3 (4H) YL)BENZOHYDRAZIDE; 4(3H) QUINAZOLINONE DERIVATIVE; 6,8 DIBROMO 2 METHYL 3 [4 (3 PHENYL 5 PARA TOLYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL)PHENYL]QUINAZOLIN 4 (3H)ONE; 6,8 DIBROMO 2 METHYL 3 [4 [5 (3 NITROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL]QUINAZOLIN 4 (3H)ONE; 6,8 DIBROMO 3 [4 [5 (4 CHLOROPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 6,8 DIBROMO 3 [4 [5 (4 HYDROXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONY]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 6,8 DIBROMO 3 [4 [5 (4 METHOXYPHENYL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONY]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; 6,8 DIBROMO 3 [4 [5 [4 (DIMETHYLAMINO)PHENYL] 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBONYL]PHENYL] 2 METHYLQUINAZOLIN 4 (3H)ONE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOTOIN; HARKOSERIDE; PHENYTOIN; PYRAZOLE DERIVATIVE; RUFINAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; EPILEPSY; HYDROGEN BOND; HYDROPHOBICITY; NEUROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SEIZURE THRESHOLD;

EID: 84879685433     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0169-9     Document Type: Article

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