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Volumn 5, Issue 12, 2006, Pages 1064-1067

Antiepileptic drugs in development

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BRIVARACETAM; CLOBAZAM; ESLICARBAZEPINE; ETIRACETAM; FELBAMATE; FLUOROEFELBAMATE; GABAPENTIN; GANAXALONE; LAMOTRIGINE; LOCOSAMIDE; OXCARBAZEPINE; PREGABALIN; RETIGABINE; RUFINAMIDE; RWJ 333369; SAFINAMIDE; SELECTRACETAM; STIRIPENTOL; TALAMPANEL; TIAGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; VALROCEMIDE; VIGABATRIN; ZONISAMIDE;

EID: 33750695268     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(06)70627-5     Document Type: Short Survey
Times cited : (51)

References (31)
  • 1
    • 0038821615 scopus 로고    scopus 로고
    • Levy R., Mattson R., Meldrum B., and Perucca E. (Eds), Lippincott Williams and Wilkins, Philadelphia
    • Pellock J., Perhach J., and Felbamate Sofia R. In: Levy R., Mattson R., Meldrum B., and Perucca E. (Eds). Antiepileptic drugs. 5th edn. (2002), Lippincott Williams and Wilkins, Philadelphia 301-320
    • (2002) Antiepileptic drugs. 5th edn. , pp. 301-320
    • Pellock, J.1    Perhach, J.2    Felbamate Sofia, R.3
  • 2
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski M., and Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 5 (2004) 553-564
    • (2004) Nat Rev Neurosci , vol.5 , pp. 553-564
    • Rogawski, M.1    Loscher, W.2
  • 3
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P., and Brodie M. Early identification of refractory epilepsy. N Engl J Med 342 (2000) 314-319
    • (2000) N Engl J Med , vol.342 , pp. 314-319
    • Kwan, P.1    Brodie, M.2
  • 4
    • 4644301804 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)
    • Bialer M., Johannessen S., Kupferberg H., Levy R., Perucca E., and Tomson T. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res 61 (2004) 1-48
    • (2004) Epilepsy Res , vol.61 , pp. 1-48
    • Bialer, M.1    Johannessen, S.2    Kupferberg, H.3    Levy, R.4    Perucca, E.5    Tomson, T.6
  • 5
    • 33747049831 scopus 로고    scopus 로고
    • Diverse mechanisms of antiepileptic drugs in the development pipeline
    • Rogawski M. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res 69 (2006) 273-294
    • (2006) Epilepsy Res , vol.69 , pp. 273-294
    • Rogawski, M.1
  • 6
    • 21344456412 scopus 로고    scopus 로고
    • ucb 34714, a new pyrrolidone derivative, inhibits Na+-currents in rat cortical neurons in culture
    • Zona C., Pieri M., Klitgaard H., and Margineanu D. ucb 34714, a new pyrrolidone derivative, inhibits Na+-currents in rat cortical neurons in culture. Epilepsia 45 suppl 7 (2004) 146
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 146
    • Zona, C.1    Pieri, M.2    Klitgaard, H.3    Margineanu, D.4
  • 7
    • 21344470757 scopus 로고    scopus 로고
    • UCB 34714: single and multiple rising dose safety, tolerability and pharmacokinetics in healthy subjects
    • Rolan P., Pegeolet E., and Stockis A. UCB 34714: single and multiple rising dose safety, tolerability and pharmacokinetics in healthy subjects. Epilepsia 45 suppl 7 (2004) 314
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 314
    • Rolan, P.1    Pegeolet, E.2    Stockis, A.3
  • 10
    • 2342426213 scopus 로고    scopus 로고
    • Valrocemide (Teva/Acorda)
    • Hovinga C. Valrocemide (Teva/Acorda). Curr Opin Investig Drugs 5 (2004) 101-106
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 101-106
    • Hovinga, C.1
  • 11
    • 27644510366 scopus 로고    scopus 로고
    • The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model
    • Duncan G., and Kohn H. The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model. Epilepsy Res 67 (2005) 81-87
    • (2005) Epilepsy Res , vol.67 , pp. 81-87
    • Duncan, G.1    Kohn, H.2
  • 12
    • 30344461897 scopus 로고    scopus 로고
    • Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro
    • Lees G., Stohr T., and Errington A. Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro. Neuropharmacology 50 (2006) 98-110
    • (2006) Neuropharmacology , vol.50 , pp. 98-110
    • Lees, G.1    Stohr, T.2    Errington, A.3
  • 13
    • 25844499529 scopus 로고    scopus 로고
    • Efficacy and Safety of Adjunctive Oral Lacosamide for the Treatment of Partial-Onset Seizures in Patients with Epilepsy
    • SP667 Study Group
    • Ben-Menachem E., Jatuzis D., Abou-Khalil B., Doty P., Rudd G., and SP667 Study Group. Efficacy and Safety of Adjunctive Oral Lacosamide for the Treatment of Partial-Onset Seizures in Patients with Epilepsy. Neurology 64 suppl 1 (2005) A187
    • (2005) Neurology , vol.64 , Issue.SUPPL. 1
    • Ben-Menachem, E.1    Jatuzis, D.2    Abou-Khalil, B.3    Doty, P.4    Rudd, G.5
  • 14
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    • Rundfeldt C., and Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits. Neurosci Lett 282 (2000) 73-76
    • (2000) Neurosci Lett , vol.282 , pp. 73-76
    • Rundfeldt, C.1    Netzer, R.2
  • 15
    • 0034533728 scopus 로고    scopus 로고
    • Investigations into the mechanism of action of the new anticonvulsant retigabine: interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels
    • Rundfeldt C., and Netzer R. Investigations into the mechanism of action of the new anticonvulsant retigabine: interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 50 (2000) 1063-1070
    • (2000) Arzneimittelforschung , vol.50 , pp. 1063-1070
    • Rundfeldt, C.1    Netzer, R.2
  • 16
    • 0032542232 scopus 로고    scopus 로고
    • Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
    • Schroeder B., Kubisch C., Stein V., and Jentsch T. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 396 (1998) 687-690
    • (1998) Nature , vol.396 , pp. 687-690
    • Schroeder, B.1    Kubisch, C.2    Stein, V.3    Jentsch, T.4
  • 17
    • 0029891002 scopus 로고    scopus 로고
    • D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures
    • Tober C., Rostock A., Rundfeldt C., and Bartsch R. D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. Eur J Pharmacol 303 (1996) 163-169
    • (1996) Eur J Pharmacol , vol.303 , pp. 163-169
    • Tober, C.1    Rostock, A.2    Rundfeldt, C.3    Bartsch, R.4
  • 18
    • 0029969951 scopus 로고    scopus 로고
    • D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
    • Rostock A., Tober C., Rundfeldt C., et al. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res 23 (1996) 211-223
    • (1996) Epilepsy Res , vol.23 , pp. 211-223
    • Rostock, A.1    Tober, C.2    Rundfeldt, C.3
  • 19
    • 1242283867 scopus 로고    scopus 로고
    • M-current modulators alter rat spinal nociceptive transmission: an electrophysiological study in vitro
    • Rivera-Arconada I., Martinez-Gomez J., and Lopez-Garcia J. M-current modulators alter rat spinal nociceptive transmission: an electrophysiological study in vitro. Neuropharmacology 46 (2004) 598-606
    • (2004) Neuropharmacology , vol.46 , pp. 598-606
    • Rivera-Arconada, I.1    Martinez-Gomez, J.2    Lopez-Garcia, J.3
  • 20
    • 0037462422 scopus 로고    scopus 로고
    • The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
    • Blackburn-Munro G., and Jensen B. The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur J Pharmacol 460 (2003) 109-116
    • (2003) Eur J Pharmacol , vol.460 , pp. 109-116
    • Blackburn-Munro, G.1    Jensen, B.2
  • 21
    • 33745604940 scopus 로고    scopus 로고
    • Retigabine: in partial seizures
    • Plosker G., and Scott L. Retigabine: in partial seizures. CNS Drugs 20 (2006) 601-608
    • (2006) CNS Drugs , vol.20 , pp. 601-608
    • Plosker, G.1    Scott, L.2
  • 22
    • 22244452355 scopus 로고    scopus 로고
    • Rufinamide: CGP 33101, E 2080, RUF 331, Xilep
    • Rufinamide: CGP 33101, E 2080, RUF 331, Xilep. Drugs R D 6 (2005) 249-252
    • (2005) Drugs R D , vol.6 , pp. 249-252
  • 23
    • 32744471584 scopus 로고    scopus 로고
    • Efficacy and safety of rufinamide as adjunctive therapy in adult patients with therapy-resistant partial-onset seizures
    • Vazquez B., Maxoutova A., et al. Efficacy and safety of rufinamide as adjunctive therapy in adult patients with therapy-resistant partial-onset seizures. Epilepsia 37 suppl 7 (2000) 255
    • (2000) Epilepsia , vol.37 , Issue.SUPPL. 7 , pp. 255
    • Vazquez, B.1    Maxoutova, A.2
  • 24
    • 33748525044 scopus 로고    scopus 로고
    • Efficacy and safety of rufinamide adjunctive therapy in patients with Lennox-Gastaut syndrome (LGS): a multicenter, randomized, double-blind, placebo-controlled, parallel trial: LBS.001
    • Glauser T., Kluger G., Sachedo R., Krauss G., Perdomo C., and Arroyo S. Efficacy and safety of rufinamide adjunctive therapy in patients with Lennox-Gastaut syndrome (LGS): a multicenter, randomized, double-blind, placebo-controlled, parallel trial: LBS.001. Neurology 64 (2005) 1826
    • (2005) Neurology , vol.64 , pp. 1826
    • Glauser, T.1    Kluger, G.2    Sachedo, R.3    Krauss, G.4    Perdomo, C.5    Arroyo, S.6
  • 25
    • 0037062597 scopus 로고    scopus 로고
    • A crossover, add-on trial of talampanel in patients with refractory partial seizures
    • Chappell A., Sander J., Brodie M., et al. A crossover, add-on trial of talampanel in patients with refractory partial seizures. Neurology 58 (2002) 1680-1682
    • (2002) Neurology , vol.58 , pp. 1680-1682
    • Chappell, A.1    Sander, J.2    Brodie, M.3
  • 26
    • 0036247871 scopus 로고    scopus 로고
    • Non-competitive AMPA antagonists of 2,3-benzodiazepine type
    • Solyom S., and Tarnawa I. Non-competitive AMPA antagonists of 2,3-benzodiazepine type. Curr Pharm Des 8 (2002) 913-939
    • (2002) Curr Pharm Des , vol.8 , pp. 913-939
    • Solyom, S.1    Tarnawa, I.2
  • 27
    • 0030869099 scopus 로고    scopus 로고
    • Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity
    • Monaghan E., Navalta L., Shum L., Ashbrook D., and Lee D. Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity. Epilepsia 38 (1997) 1026-1031
    • (1997) Epilepsia , vol.38 , pp. 1026-1031
    • Monaghan, E.1    Navalta, L.2    Shum, L.3    Ashbrook, D.4    Lee, D.5
  • 28
    • 0032846421 scopus 로고    scopus 로고
    • Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy
    • Monaghan E., McAuley J., and Data J. Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy. Expert Opin Investig Drugs 8 (1999) 1663-1671
    • (1999) Expert Opin Investig Drugs , vol.8 , pp. 1663-1671
    • Monaghan, E.1    McAuley, J.2    Data, J.3
  • 29
    • 0033759542 scopus 로고    scopus 로고
    • Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial
    • Kerrigan J., Shields W., Nelson T., et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res 42 (2000) 133-139
    • (2000) Epilepsy Res , vol.42 , pp. 133-139
    • Kerrigan, J.1    Shields, W.2    Nelson, T.3
  • 30
    • 0034638786 scopus 로고    scopus 로고
    • Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group
    • Chiron C., Marchand M., Tran A., et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet 356 (2000) 1638-1642
    • (2000) Lancet , vol.356 , pp. 1638-1642
    • Chiron, C.1    Marchand, M.2    Tran, A.3
  • 31
    • 0036351947 scopus 로고    scopus 로고
    • Potential new methods for antiepileptic drug delivery
    • Fisher R., and Ho J. Potential new methods for antiepileptic drug delivery. CNS Drugs 16 (2002) 579-593
    • (2002) CNS Drugs , vol.16 , pp. 579-593
    • Fisher, R.1    Ho, J.2


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