Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2467-2472

  Alam, Ozair ^a   Mullick, Pooja ^a   Verma, S P ^a   Gilani, Sadaf J ^a   Khan, Suroor A ^a   Siddiqui, Nadeem ^a   Ahsan, Waquar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsants; Distance mapping; Hepatotoxicity; Neurotoxicity; Pyrimidine; Semicarbazones

Indexed keywords

ANTICONVULSIVE AGENT; ETHOSUXIMIDE; LIVER ENZYME; LIVER PROTEIN; N (4,6 DIPHENYLPYRIMIDIN 2 YL)SEMICARBAZONE DERIVATIVE; N1 [4 (4 CHLOROPHENYL) 6 (3,4 DIMETHOXYPHENYL)PYRIMIDIN 2 YL] N4 (4 NITROBENZALDEHYDE)SEMICARBAZONE; N1 [4 (4 CHLOROPHENYL) 6 (4 METHYLPHENYL)PYRIMIDIN 2 YL] N4 (4 CHLOROACETOPHENONE)SEMICARBAZONE; N1 [4 (4 FLUOROPHENYL) 6 (4 METHYLPHENYL)PYRIMIDIN 2 YL] N4 (4 CHLOROACETOPHENONE)SEMICARBAZONE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; PYRIMIDINE SEMICARBAZONE DERIVATIVE; SEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG MEGADOSE; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; FEMALE; LIVER; LOW DRUG DOSE; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; SEIZURE;

ANIMALS; ANTICONVULSANTS; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; EPILEPSY; LIVER; MICE; NERVOUS SYSTEM; PYRIMIDINES; SEMICARBAZONES;

EID: 77950857514     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.031     Document Type: Article

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