Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives

Archiv der Pharmazie

Volumn 341, Issue 11, 2008, Pages 701-707

  Ozdemir, Zuhal ^a   Kandilci, H Burak ^a   Gumusel, Bulent ^a   Calis, Unsal ^a   Bilgin, A Altan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

3 Pyrazoline derivatives; Anticonvulsant activity; Antidepressant activity

Indexed keywords

1 N METHYLTHIOCARBAMOYL 3,5 DI (2 THIENYL) 2 PYRAZOLINE; 1 N PHENYLTHIOCARBAMOYL 3 (2 THIENYL) 5 PHENYL 2 PYRAZOLINE; 1 N PHENYLTHIOCARBAMOYL 3,5 DI (2 THIENYL) 2 PYRAZOLINE; PENTETRAZOLE; PYRAZOLINE DERIVATIVE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG INDICATION; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICROANALYSIS; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROTAROD TEST; SEIZURE; TOXICITY TESTING; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR STRUCTURE; PYRAZOLES; SEIZURES; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349104435     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800068     Document Type: Article

References (26)

1. R. I. Shader, D. J. Greenblatt, J. Clin. Psychopharmacol. 1999, 19, 201-202.
2. S. S. Parmar, B. R. Pandey, C. Dwivedi, R. D. Harbison, J. Pharm. Sci. 1974, 63, 1152-1155.
3. N. Soni, K. Pande, R. Kalsi, T. K. Gupta, et al., Res. Commun. Chem. Pathol. Pharmacol. 1987, 56, 129-132.
4. F. Chimenti, E. Maccioni, D. Secci, A. Bolasco, et al., J. Med. Chem. 2005, 48, 7113-7122.
5. R. I. Shader, D. J. Greenblatt, J. Clin. Psychopharmacol. 1999, 19, 105-106.
6. L. J. Urichuk, K. Allison, A. Holt, A. J. Greenshaw, G. B. Baker, J. Affect Disord. 2000, 58, 135-144.
7. A. A. Bilgin, E. Palaska, R. Sunal, B. Gümüsel, Pharmazie 1994, 49, 67-69.
8. A. A. Bilgin, E. Palaska, R. Sunal, Arzneimittelforschung 1993, 43, 1041-1044.
9. A. A. Bilgin, A. Yesilada, E. Palaska, R. Sunal, Arzneimittelforschung 1992, 42, 1271-1273.
10. N. Gökhan, A. Yesilada, G. Ucar, K. Erol, A. A. Bilgin, Arch. Pharm. Pharm. Med. Chem. 2003, 336, 362-371.
11. O. Ruhoglu, Z. Ozdemir, U. Calis, B. Gumusel, A. A. Bilgin, Arzneimittelforschung 2005, 55, 431-436.
12. P. Iyidogan, Z. Özdemir, H. B. Kandilci, B. Gümüsel, et al., J. Fac. Pharm. Istanbul 2006, 38, 47-56.
13. Z. Ozdemir, H. B. Kandilci, B. Gumusel, U. Calis, A. A. Bilgin, Eur. J. Med. Chem. 2007, 42, 373-379.
14. Y. Rajendra Prasad, A. Lakshmana Rao, L. Prasoona, K. Murali, P. Ravi Kumar, Bioorg. Med. Chem. Lett. 2005, 15, 5030-5034.
15. W. Ried, G. Dankert, Chem. Ber. 1957, 90, 2707-2711.
16. R. D. Porsolt, A. Bertin, M. Jalfre, Arch. Int. Pharmacodyn. Ther. 1977, 229, 327-336.
17. M. Bourin, M. Hascoet, M. C. Colombel, R. T. Coutts, G. B. Baker, J. Psychiatry Neurosci. 2002, 27, 178-185.
18. R. D. Porsolt in Antidepressants; Neurochemical, Behavioral and Clinical Perspective (Eds.: S. J. Enna, J. B. Malick, E. Richelson), Raven Press, New York, 1981, pp. 121-128.
19. P. Willner, P. J. Mitchell, Behav. Pharmacol. 2002, 13, 169-188.
20. H. Schäfer in Handbook of Experimental Pharmacology: Antiepileptic Drugs (Eds.: H. H. Frey, D. Janz), Springer-Verlag, Berlin, 1985, pp. 199-210.
21. R. L. Krall, J. K. Penry, B. G. White, H. J. Kupferberg, E. A. Swinyard, Epilepsia 1978, 19, 409-428.
22. St. v. Kostanecki, L. Podrajansky, Chem. Ber. 1896, 29, 2248-2250.
23. W. E. Kaufmann, R. Adams, J. Am. Chem. Soc. 1923, 45, 3029-3044.
24. C. Weygand, F. Strobelt, Chem. Ber. 1935, 68B, 1839-1847.
25. W. S. Emerson, T. M. Patrick, J. Org. Chem. 1949, 14, 790-797.
26. A. S. Angeloni, A. Bellotti, E. Coghi, Ann. Chim. 1963, 53, 1392-1398.