Epidermal growth factors in the kidney and relationship to hypertension

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 1, 2013, Pages

  Staruschenko, Alexander ^a   Palygin, Oleg ^a   Ilatovskaya, Daria V ^a   Pavlov, Tengis S ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

EGFR; ENaC; Epidermal growth factor; ErbB receptor; Salt sensitive hypertension

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR;

ACUTE KIDNEY FAILURE; CHRONIC KIDNEY DISEASE; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; MOLECULAR BIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SODIUM ABSORPTION; SODIUM TRANSPORT;

EID: 84879586136     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00112.2013     Document Type: Review

References (134)

1. Amin MS, Reza E, El-Shahat E, Wang HW, Tesson F, Leenen FH. Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats. Can J Physiol Pharmacol 89: 159-168, 2011.
2. Aoi W, Niisato N, Sawabe Y, Miyazaki H, Marunaka Y. Aldosteroneinduced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat. Biochem Biophys Res Commun 341: 376-381, 2006.
3. Aoi W, Niisato N, Sawabe Y, Miyazaki H, Tokuda S, Nishio K, Yoshikawa T, Marunaka Y. Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats. Cell Biol Int 31: 1288-1291, 2007.
4. Beltowski J, Lowicka E. EGF receptor as a drug target in arterial hypertension. Mini Rev Med Chem 9: 526-538, 2009.
5. Benter IF, Canatan H, Benboubetra M, Yousif MH, Akhtar S. Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis. Vascul Pharmacol 51: 101-109, 2009.
6. Berger MB, Mendrola JM, Lemmon MA. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. FEBS Lett 569: 332-336, 2004.
7. Bhalla V, Hallows KR. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol 19: 1845-1854, 2008.
8. Blaikie P, Immanuel D, Wu J, Li N, Yajnik V, Margolis B. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem 269: 32031-32034, 1994.
9. Blobel CP, Carpenter G, Freeman M. The role of protease activity in ErbB biology. Exp Cell Res 315: 671-682, 2009.
10. Bollee G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 17: 1242-1250, 2011.
11. Carev D, Saraga M, Saraga-Babic M. Expression of intermediate filaments, EGF and TGF-alpha in early human kidney development. J Mol Histol 39: 227-235, 2008.
12. Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem 265: 7709-7712, 1990.
13. Catania JM, Chen G, Parrish AR. Role of matrix metalloproteinases in renal pathophysiologies. Am J Physiol Renal Physiol 292: F905-F911, 2007.
14. Chansel D, Ciroldi M, Vandermeersch S, Jackson LF, Gomez AM, Henrion D, Lee DC, Coffman TM, Richard S, Dussaule JC, Tharaux PL. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J 20: 1936-1938, 2006.
15. Chen J, Chen JK, Harris RC. Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int 82: 45-52, 2012.
16. Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC. EGFR signaling promotes TGFbetadependent renal fibrosis. J Am Soc Nephrol 23: 215-224, 2012.
17. Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 284: 54-65, 2003.
18. Cotton CU, Hobert ME, Ryan S, Carlin CR. Basolateral EGF receptor sorting regulated by functionally distinct mechanisms in renal epithelial cells. Traffic 14: 337-354, 2013.
19. Cowley AW Jr, Roman RJ. The role of the kidney in hypertension. JAMA 275: 1581-1589, 1996.
20. De Miguel C, Lund H, Mattson DL. High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney. Hypertension 57: 269-274, 2011.
21. De Miguel C, Guo C, Lund H, Feng D, Mattson DL. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. Am J Physiol Renal Physiol 300: F734-F742, 2011.
22. Dimke H, van der WJ, Alexander TR, Meijer IM, Mulder GM, van GH, Tejpar S, Hoenderop JG, Bindels RJ. Effects of the EGFR inhibitor erlotinib on magnesium handling. J Am Soc Nephrol 21: 1309-1316, 2010.
23. 2 regulates lung ENaC via ubiquitin-like protein Nedd8. J Biol Chem 288: 8136-8145, 2013.
24. Escano CS Jr, Keever LB, Gutweiler AA, Andresen BT. Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation. J Pharmacol Exp Ther 324: 34-42, 2008.
25. Falin R, Veizis IE, Cotton CU. A role for ERK1/2 in EGF-and ATP-dependent regulation of amiloride-sensitive sodium absorption. Am J Physiol Cell Physiol 288: C1003-C1011, 2005.
26. Falin RA, Cotton CU. Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site. J Gen Physiol 130: 313-328, 2007.
27. Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Exp Cell Res 315: 707-716, 2009.
28. phox in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab 15: 201-208, 2012.
29. Feng L, Garcia GE, Yang Y, Xia Y, Gabbai FB, Peterson OW, Abraham JA, Blantz RC, Wilson CB. Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats. J Clin Invest 105: 341-350, 2000.
30. Fisher DA, Salido EC, Barajas L. Epidermal growth factor and the kidney. Annu Rev Physiol 51: 67-80, 1989.
31. Flamant M, Bollee G, Henique C, Tharaux PL. Epidermal growth factor: a new therapeutic target in glomerular disease. Nephrol Dial Transplant 27: 1297-1304, 2012.
32. Florian JA, Watts SW. Epidermal growth factor: a potent vasoconstrictor in experimental hypertension. Am J Physiol Heart Circ Physiol 276: H976-H983, 1999.
33. Frindt G, Ergonul Z, Palmer LG. Surface expression of epithelial Na channel protein in rat kidney. J Gen Physiol 131: 617-627, 2008.
34. Gesualdo L, Di PS, Calabro A, Milani S, Maiorano E, Ranieri E, Pannarale G, Schena FP. Expression of epidermal growth factor and its receptor in normal and diseased human kidney: an immunohistochemical and in situ hybridization study. Kidney Int 49: 656-665, 1996.
35. Goodyer PR, Fata J, Mulligan L, Fischer D, Fagan R, Guyda HJ, Goodyer CG. Expression of transforming growth factor-alpha and epidermal growth factor receptor in human fetal kidneys. Mol Cell Endocrinol 77: 199-206, 1991.
36. Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16: 1647-1655, 1997.
37. + reabsorption. Am J Physiol Renal Physiol 286: F1226-F1231, 2004.
38. Hao L, Du M, Lopez-Campistrous A, Fernandez-Patron C. Agonistinduced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Circ Res 94: 68-76, 2004.
39. Harris RC, Chung E, Coffey RJ. EGF receptor ligands. Exp Cell Res 284: 2-13, 2003.
40. Harris RC, Hoover RL, Jacobson HR, Badr KF. Evidence for glomerular actions of epidermal growth factor in the rat. J Clin Invest 82: 1028-1039, 1988.
41. He S, Liu N, Bayliss G, Zhuang S. EGFR activity is required for renal tubular cell dedifferentiation and proliferation in a murine model of folic acid-induced acute kidney injury. Am J Physiol Renal Physiol 304: F356-F366, 2013.
42. Helle F, Jouzel C, Chadjichristos C, Placier S, Flamant M, Guerrot D, Francois H, Dussaule JC, Chatziantoniou C. Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism. Am J Physiol Renal Physiol 297: F191-F199, 2009.
43. Holbro T, Hynes NE. ErbB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol 44: 195-217, 2004.
44. Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ Jr, Harris RC. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest 96: 1018-1025, 1995.
45. Hong NJ, Garvin JL. Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. Hypertension 60: 765-769, 2012.
46. Ikari A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M. TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells. Biochem Biophys Res Commun 369: 1129-1133, 2008.
47. Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M. Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J Cell Physiol 222: 481-487, 2010.
48. Ilatovskaya DV, Pavlov TS, Levchenko V, Staruschenko A. ROS production as a common mechanism of ENaC regulation by EGF, insulin and IGF-1. Am J Physiol Cell Physiol 304: C102-C111, 2013.
49. Jung JY, Song JH, Li C, Yang CW, Kang TC, Won MH, Jeong YG, Han KH, Choi KB, Lee SH, Kim J. Expression of epidermal growth factor in the developing rat kidney. Am J Physiol Renal Physiol 288: F227-F235, 2005.
50. Kagiyama S, Eguchi S, Frank GD, Inagami T, Zhang YC, Phillips MI. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation 106: 909-912, 2002.
51. Kakizoe Y, Kitamura K, Ko T, Wakida N, Maekawa A, Miyoshi T, Shiraishi N, Adachi M, Zhang Z, Masilamani S, Tomita K. Aberrant ENaC activation in Dahl salt-sensitive rats. J Hypertens 27: 1679-1689, 2009.
52. + channel. Hypertension 57: 996-1002, 2011.
53. Kashles O, Szapary D, Bellot F, Ullrich A, Schlessinger J, Schmidt A. Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions. Proc Natl Acad Sci USA 85: 9567-9571, 1988.
54. Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T. Angiotensin II-and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation. J Am Soc Nephrol 23: 997-1007, 2012.
55. Kramarenko II, Bunni MA, Raymond JR, Garnovskaya MN. Bradykinin B2 receptor interacts with integrin α5β1 to transactivate epidermal growth factor receptor in kidney cells. Mol Pharmacol 78: 126-134, 2010.
56. Laouari D, Burtin M, Phelep A, Martino C, Pillebout E, Montagutelli X, Friedlander G, Terzi F. TGF-alpha mediates genetic susceptibility to chronic kidney disease. J Am Soc Nephrol 22: 327-335, 2011.
57. Lautrette A, Li S, Alili R, Sunnarborg SW, Burtin M, Lee DC, Friedlander G, Terzi F. Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat Med 11: 867-874, 2005.
58. Lee SB, Huang K, Palmer R, Truong VB, Herzlinger D, Kolquist KA, Wong J, Paulding C, Yoon SK, Gerald W, Oliner JD, Haber DA. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell 98: 663-673, 1999.
59. c14 cells via ErbB2 (neu/HER-2) receptor. J Cell Physiol 223: 252-259, 2010.
60. 2+ channels through an inositol 1,4,5-trisphosphate-independent pathway in human glomerular mesangial cells. J Biol Chem 279: 4570-4577, 2004.
61. Liang L, Li L, Zeng J, Gao Y, Chen YL, Wang ZQ, Wang XY, Chang LS, He D. Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway. Oncol Rep 28: 999-1005, 2012.
62. Liu L, Duke BJ, Malik B, Yue Q, Eaton DC. Biphasic regulation of ENaC by TGF-α and EGF in renal epithelial cells. Am J Physiol Renal Physiol 296: F1417-F1427, 2009.
63. Liu N, Guo JK, Pang M, Tolbert E, Ponnusamy M, Gong R, Bayliss G, Dworkin LD, Yan H, Zhuang S. Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol 23: 854-867, 2012.
64. Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS ONE 7: e49418, 2012.
65. Ma HP. Hydrogen peroxide stimulates the epithelial sodium channel through a phosphatidylinositide 3-kinase-dependent pathway. J Biol Chem 286: 32444-32453, 2011.
66. Ma R, Sansom SC. Epidermal growth factor activates store-operated calcium channels in human glomerular mesangial cells. J Am Soc Nephrol 12: 47-53, 2001.
67. Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol 25: 8285-8298, 2005.
68. MacRae DK, Nemo R, Sweeney WE Jr, Avner ED. EGF-related growth factors in the pathogenesis of murine ARPKD. Kidney Int 65: 2018-2029, 2004.
69. + channel (ENaC) in the distal nephron additively to aldosterone. J Biol Chem 287: 660-671, 2012.
70. Markadieu N, Crutzen R, Blero D, Erneux C, Beauwens R. Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers. Am J Physiol Renal Physiol 288: F1201-F1212, 2005.
71. Melenhorst WB, Mulder GM, Xi Q, Hoenderop JG, Kimura K, Eguchi S, van Goor H. Epidermal growth factor receptor signaling in the kidney: key roles in physiology and disease. Hypertension 52: 987-993, 2008.
72. Melenhorst WB, Visser L, Timmer A, van den Heuvel MC, Stegeman CA, van Goor H. ADAM17 upregulation in human renal disease: a role in modulating TGF-α availability? Am J Physiol Renal Physiol 297: F781-F790, 2009.
73. Minner S, Rump D, Tennstedt P, Simon R, Burandt E, Terracciano L, Moch H, Wilczak W, Bokemeyer C, Fisch M, Sauter G, Eichelberg C. Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma. Cancer 118: 1268-1275, 2012.
74. Mishra R, Leahy P, Simonson MS. Gene expression profiling reveals role for EGF-family ligands in mesangial cell proliferation. Am J Physiol Renal Physiol 283: F1151-F1159, 2002.
75. Muto S, Furuya H, Tabei K, Asano Y. Site and mechanism of action of epidermal growth factor in rabbit cortical collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 260: F163-F169, 1991.
76. Nagase M, Fujita T. Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease. Nat Rev Nephrol 9: 86-98, 2013.
77. Nakagawa T, Hayase Y, Sasahara M, Haneda M, Kikkawa R, Higashiyama S, Taniguchi N, Hazama F. Distribution of heparinbinding EGF-like growth factor protein and mRNA in the normal rat kidneys. Kidney Int 51: 1774-1779, 1997.
78. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell-and region-specific manner and acts to inhibit apoptosis. Am J Pathol 156: 889-898, 2000.
79. Nouwen EJ, de Broe ME. EGF and TGF-alpha in the human kidney: identification of octopal cells in the collecting duct. Kidney Int 45: 1510-1521, 1994.
80. Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 291: C1-C10, 2006.
81. Oka Y, Fujiwara K, Endou H. Intranephron distribution of epidermal growth factor immunoreactivity in the mouse. Renal Physiol 10: 283-288, 1987.
82. Pavlov TS, Levchenko V, O'Connor PM, Ilatovskaya DV, Palygin O, Mori T, Mattson DL, Sorokin A, Lombard JD, Cowley AW Jr, Staruschenko A. Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension. J Am Soc Nephrol 2013 Apr 18 [Epub ahead of print].
83. Pavlov TS, Ilatovskaya DV, Levchenko V, Mattson DL, Roman RJ, Staruschenko A. Effects of cytochrome P450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol 301: F672-F681, 2011.
84. Perheentupa J, Lakshmanan J, Hoath SB, Beri U, Kim H, Macaso T, Fisher DA. Epidermal growth factor measurements in mouse plasma: method, ontogeny, and sex difference. Am J Physiol Endocrinol Metab 248: E391-E396, 1985.
85. Pidkovka N, Rao R, Mei S, Gong Y, Harris RC, Wang WH, Capdevila JH. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. J Biol Chem 288: 5223-5231, 2013.
86. 2-receptor tone. FASEB J 24: 2056-2065, 2010.
87. Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 5: 953-962, 1990.
88. Sakai M, Zhang M, Homma T, Garrick B, Abraham JA, McKanna JA, Harris RC. Production of heparin binding epidermal growth factorlike growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest 99: 2128-2138, 1997.
89. Salido EC, Barajas L, Lechago J, Laborde NP, Fisher DA. Immunocytochemical localization of epidermal growth factor in mouse kidney. J Histochem Cytochem 34: 1155-1160, 1986.
90. Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors 24: 121-136, 2006.
91. Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110: 669-672, 2002.
92. Schlingmann KP, Weber S, Peters M, Niemann NL, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31: 166-170, 2002.
93. Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nat Rev Cancer 12: 278-287, 2012.
94. Shen JP, Cotton CU. Epidermal growth factor inhibits amiloridesensitive sodium absorption in renal collecting duct cells. Am J Physiol Renal Physiol 284: F57-F64, 2003.
95. Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest 121: 3233-3243, 2011.
96. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 14: 1370-1376, 2008.
97. Singh AB, Harris RC. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal 17: 1183-1193, 2005.
98. Smith JP, Pozzi A, Dhawan P, Singh AB, Harris RC. Soluble HBEGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2. Am J Physiol Renal Physiol 296: F957-F965, 2009.
99. Sorkin A, Goh LK. Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res 315: 683-696, 2009.
100. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci USA 106: 7804-7809, 2009.
101. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem 285: 30363-30369, 2010.
102. Staruschenko A. Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol 2: 1541-1584, 2012.
103. Sun P, Yue P, Wang WH. Angiotensin II stimulates epithelial sodium channels (ENaC) in the cortical collecting duct of the rat kidney. Am J Physiol Renal Physiol 302: F679-F687, 2012.
104. Suzuki M, Raab G, Moses MA, Fernandez CA, Klagsbrun M. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J Biol Chem 272: 31730-31737, 1997.
105. Swaminathan N, Sambhi MP. Induction of high affinity epidermal growth factor binding in the aorta of Dahl hypertensive rats fed with high salt diet. Hypertens Res 19: 65-68, 1996.
106. Swaminathan N, Vincent M, Sassard J, Sambhi MP. Elevated epidermal growth factor receptor levels in hypertensive Lyon rat kidney and aorta. Clin Exp Pharmacol Physiol 23: 793-796, 1996.
107. Tan RJ, Liu Y. Matrix metalloproteinases in kidney homeostasis and diseases. Am J Physiol Renal Physiol 302: F1351-F1361, 2012.
108. Tang J, Liu N, Zhuang S. Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int 83: 804-810, 2013
109. Terzi F, Burtin M, Hekmati M, Federici P, Grimber G, Briand P, Friedlander G. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest 106: 225-234, 2000.
110. Thebault S, Alexander RT, Tiel Groenestege WM, Hoenderop JG, Bindels RJ. EGF increases TRPM6 activity and surface expression. J Am Soc Nephrol 20: 78-85, 2009.
111. Thomasson M, Hedman H, Ljungberg B, Henriksson R. Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma. BMC Res Notes 5: 216, 2012.
112. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa HH, Coffey RJ, Magnuson T. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269: 230-234, 1995.
113. Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G. Homo-and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci USA 94: 6965-6970, 1997.
114. Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ, Yarden Y. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 16: 5276-5287, 1996.
115. Ulu N, Gurdal H, Landheer SW, Duin M, Guc MO, Buikema H, Henning RH. α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor. Br J Pharmacol 161: 1301-1310, 2010.
116. Uttarwar L, Peng F, Wu D, Kumar S, Gao B, Ingram AJ, Krepinsky JC. HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells. Am J Physiol Renal Physiol 300: F921-F931, 2011.
117. Vaughan TJ, James PS, Pascall JC, Brown KD. Molecular cloning and tissue distribution of pig transforming growth factor alpha. Biochem J 296: 837-842, 1993.
118. Vaughan TJ, Pascall JC, James PS, Brown KD. Expression of epidermal growth factor and its mRNA in pig kidney, pancreas and other tissues. Biochem J 279: 315-318, 1991.
119. Vehaskari VM, Hering-Smith KS, Moskowitz DW, Weiner ID, Hamm LL. Effect of epidermal growth factor on sodium transport in the cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 256: F803-F809, 1989.
120. Vehaskari VM, Herndon J, Hamm LL. Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts. Am J Physiol Renal Fluid Electrolyte Physiol 261: F896-F903, 1991.
121. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92: 827-839, 2003.
122. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, Sheffield VC. Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31: 171-174, 2002.
123. + pump. Am J Physiol Renal Fluid Electrolyte Physiol 264: F670-F677, 1993.
124. Wei Y, Lin DH, Kemp R, Yaddanapudi GS, Nasjletti A, Falck JR, Wang WH. Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol 124: 719-727, 2004.
125. Williams JM, Zhang J, North P, Lacy S, Yakes M, Dahly-Vernon A, Roman RJ. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol 300: F983-F998, 2011.
126. Wilson PD. Polycystic kidney disease. N Engl J Med 350: 151-164, 2004.
127. Wilson PD. Apico-basal polarity in polycystic kidney disease epithelia. Biochim Biophys Acta 1812: 1239-1248, 2011.
128. Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology 25: 85-101, 2010.
129. Ying WZ, Sanders PW. Enhanced expression of EGF receptor in a model of salt-sensitive hypertension. Am J Physiol Renal Physiol 289: F314-F321, 2005.
130. Zeng F, Singh AB, Harris RC. The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res 315: 602-610, 2009.
131. Zeng F, Zhang MZ, Singh AB, Zent R, Harris RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell 18: 4446-4456, 2007.
132. Zheleznova NN, Yang C, Ryan RP, Halligan BD, Liang M, Greene AS, Cowley AW Jr. Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat. Physiol Genomics 44: 829-842, 2012.
133. Zheleznova NN, Wilson PD, Staruschenko A. Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. Biochim Biophys Acta 1812: 1301-1313, 2011.
134. Zhong H, Bowen JP. Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways. Curr Top Med Chem 11: 1571-1590, 2011.