EGF-related growth factors in the pathogenesis of murine ARPKD

Kidney International

Volumn 65, Issue 6, 2004, Pages 2018-2029

  Dell, Katherine MacRae ^a   Nemo, Raghad ^a   Sweeney Jr , William E ^a   Avner, Ellis D ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Amphiregulin; Heparin binding EGF; Immortalized cells; Mouse models; Polycystic kidney disease

Indexed keywords

AMPHIREGULIN; EPIDERMAL GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL IMMORTALIZATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; MITOGENICITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; WESTERN BLOTTING;

EID: 2442683969     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00623.x     Document Type: Article

References (45)

1. LAKSHMANAN J, EYSSELEIN V: Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease. Biochem Biophys Res Commun 197:1083-1093, 1993
2. NAKANISHI K, GATTONE VH 2ND, SWEENEY WE, AVNER ED: Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice. Pediatr Nephrol 16:45-50, 2001
3. GATTONE VH 2ND, CALVET JP: Murine infantile polycystic kidney disease: a role for reduced renal epidermal growth factor. Am J Kidney Dis 17:606-607, 1991
4. LEE DC, CHAN KW, CHAN SY: Expression of transforming growth factor alpha and epidermal growth factor receptor in adult polycystic kidney disease. J Urol 159:291-296, 1998
5. KLINGEL R, DIPPOLD W, STORKEL S, et al. Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma. Am J Kidney Dis 19:22-30, 1992
6. LOWDEN DA, LINDEMANN GW, MERLINO G, et al: Renal cysts in transgenic mice expressing transforming growth factor-alpha. J Lab Clin Med 124:386-394, 1994
7. DELL KM, NEMO R, SWEENEY WE JR., et al: A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. Kidney Int 60:1240-1248, 2001
8. RICHARDS WG, SWEENEY WE, YODER BK, et al: Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101:935-939, 1998
9. ORELLANA SA, SWEENEY WE, NEFF CD, AVNER ED: Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 47:490-499, 1995
10. DU J, WILSON PD: Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD. Am J Physiol 269:C487-C495, 1995
11. SWEENEY WE, CHEN Y, NAKANISHI K, et al. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int 57:33-40, 2000
12. HARRIS RC, CHUNG E, COFFEY RJ: EGF receptor ligands. Exp Cell Res 284:2-13, 2003
13. WELLS A: EGF receptor. Int J Biochem Cell Biol 31:637-643, 1999
14. DERYNCK R: The physiology of transforming growth factor-α. Adv Cancer Res 58:27-52, 1992
15. DAMSTRUP L, KUWADA SK, DEMPSEY PJ, et al: Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer 80:1012-1019, 1999
16. FUNATOMI H, ITAKURA J, ISHIWATA T, et al. Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy. Int J Cancer 72:512-517, 1997
17. NAUTA J, OZAWA Y, SWEENEY WE JR., et al. Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease. Pediatr Nephrol 7:163-172, 1993
18. COGSWELL C, PRICE SJ, HOU X, et al. Positional cloning of jcpk/bpk locus of the mouse. Mammalian Genome 14:242-249, 2003
19. NAUTA J, SWEENEY WE RUTLEDGE JC, AVNER ED: Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor. Pediatr Res 37:755-763, 1995
20. NAKANISHI K, SWEENEY W JR., AVNER ED: Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease. J Am Soc Nephrol 12:379-384, 2001
21. SWEENEY WE JR., KUSNER L, CARLIN CR, et al. Phenotypic analysis of conditionally immortalized cells isolated from the BPK model of ARPKD. Am J Physiol Cell Physiol 281:C1695-C1705, 2001
22. SWEENEY WE, JR., HAMAHIRA K, SWEENEY J, et al: Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability. Kidney Int 64:1310-1319, 2003
23. NAKANISHI K, SWEENEY WE JR., ZERRES K, et al. Proximal tubular cysts in fetal human autosomal recessive polycystic kidney disease. J Am Soc Nephrol 11:760-763, 2000
24. RAAB G, KLAGSBRUN M: Heparin-binding EGF-like growth factor. Biochim Biophys Acta 1333:F179-F199, 1997
25. IWAMOTO R, MEKADA E: Heparin-binding EGF-like growth factor: A juxtacrine growth factor. Cytokine Growth Factor Rev 11:335-344, 2000
26. TAKEMURA T, KONDO S, HOMMA T, et al. The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J Biol Chem 272:31036-31042, 1997
27. LEE SB, HUANG K, PALMER R, et al: The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell 98:663-673, 1999
28. BROWN CL, MEISE KS, PLOWMAN GD, et al. Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloproteinase inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem 273:17258-17268, 1998
29. BROWN CL, COFFEY RJ, DEMPSEY PJ: The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells. J Biol Chem 276:29538-29549, 2001
30. TAKEMURA T, HINO S, OKADA M, et al. Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching. Kidney Int 61:1968-1979, 2002
31. TAKEMURA T, HINO S, KUWAJIMA H, et al. Induction of collecting duct morphogenesis in vitro by heparin-binding epidermal growth factor-like growth factor. J Am Soc Nephrol 12:964-972, 2001
32. SAKAI M, ZHANG M, HOMMA T, et al. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest 99:2128-2138, 1997
33. NAKAMURA Y, HANDA K, IWAMOTO R, et al: Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor, and integrin alpha3beta1 in normal human tissues. J Histochem Cytochem 49:439-444, 2001
34. NGUYEN HT, BRIDE SH, BADAWY AB, et al. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Am J Pathol 156:889-898, 2000
35. COWLEY BD, JR., SMARDO FL, JR., GRANTHAM JJ, CALVET JP: El-evated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc Natl Acad Sci USA 84:8394-8398, 1987
36. COWLEY BD, JR., CHADWICK LJ, GRANTHAM JJ, CALVET JP: Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. J Am Soc Nephrol 1:1048-1053, 1991
37. AVNER ED, PIESCO NP, SWEENEY WE, JR., ELLIS D: Renal epithelial development in organotypic culture. Pediatr Nephrol 2:92-99, 1988
38. GRANTHAM JJ: The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: Recent advances. Am J Kidney Dis 28:788-803, 1996
39. BROOKE JS, CHA JH, EIDELS L: Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor. BMC Cell Biol 3:2, 2002
40. ZHANG L, RICE AB, ADLER K, et al: Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: A mitogen for lung fibroblasts. Am J Respir Cell Mol Biol 24:123-131, 2001
41. KIRKLAND G, PAIZIS K, WU LL, et al: Heparin-binding EGF-like growth factor mRNA is upregulated in the peri-infarct region of the remnant kidney model: In vitro evidence suggests a regulatory role in myofibroblast transformation. J Am Soc Nephrol 9:1464-1473, 1998
42. TERZI F, BURTIN M, HEKMATI M, et al: Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulointerstitial lesions after renal injury. J Clin Invest 106:225-234, 2000
43. UCHIYAMA-TANAKA Y, MATSUBARA H, NOZAWA Y, et al: Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int 60:2153-2163, 2001
44. SCHLESSINGER J: Ligand-induced, receptor-mediated dimerization and activation of the EGF receptor. Cell 110:669-672, 2002
45. FERGUSON KM, BERGER MB, MENDROLA JM, et al: EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11:507-517, 2003