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Volumn 315, Issue 4, 2009, Pages 707-716

ErbB receptors and cell polarity: New pathways and paradigms for understanding cell migration and invasion

Author keywords

Cell architecture; Cell polarity; ErbB; Invasion; Metastasis; Migration; Signaling

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 62649114637     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.10.034     Document Type: Review
Times cited : (40)

References (119)
  • 1
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • M.M. Moasser, The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis, Oncogene 26 (2007) 6469-6487.
    • (2007) Oncogene , vol.26 , pp. 6469-6487
    • Moasser, M.M.1
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • D.J. Slamon, G.M. Clark, S.G. Wong, W.J. Levin, A. Ullrich, W.L. McGuire, Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science 235 (1987) 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 4
    • 0037422206 scopus 로고    scopus 로고
    • Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas
    • M. Kobayashi, A. Iwamatsu, A. Shinohara-Kanda, S. Ihara, Y. Fukui, Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas, Oncogene 22 (2003) 1294-1301.
    • (2003) Oncogene , vol.22 , pp. 1294-1301
    • Kobayashi, M.1    Iwamatsu, A.2    Shinohara-Kanda, A.3    Ihara, S.4    Fukui, Y.5
  • 5
    • 0037429725 scopus 로고    scopus 로고
    • The ErbB receptors and their role in cancer progression
    • T. Holbro, G. Civenni, N.E. Hynes, The ErbB receptors and their role in cancer progression, Exp. Cell Res. 284 (2003) 99-110.
    • (2003) Exp. Cell Res. , vol.284 , pp. 99-110
    • Holbro, T.1    Civenni, G.2    Hynes, N.E.3
  • 6
    • 0033992633 scopus 로고    scopus 로고
    • Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
    • L.N. Klapper, M.H. Kirschbaum, M. Sela, Y. Yarden, Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors, Adv. Cancer Res. 77 (2000) 25-79.
    • (2000) Adv. Cancer Res. , vol.77 , pp. 25-79
    • Klapper, L.N.1    Kirschbaum, M.H.2    Sela, M.3    Yarden, Y.4
  • 7
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: receptor heterodimerization in development and cancer
    • M.A. Olayioye, R.M. Neve, H.A. Lane, N.E. Hynes, The ErbB signaling network: receptor heterodimerization in development and cancer, EMBO J. 19 (2000) 3159-3167.
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 9
    • 0026555656 scopus 로고
    • Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses
    • R. Lupu, R. Colomer, B. Kannan, M.E. Lippman, Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 2287-2291.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 2287-2291
    • Lupu, R.1    Colomer, R.2    Kannan, B.3    Lippman, M.E.4
  • 11
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • D. Graus-Porta, R.R. Beerli, J.M. Daly, N.E. Hynes, ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling, EMBO J. 16 (1997) 1647-1655.
    • (1997) EMBO J , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 12
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • E. Tzahar, H. Waterman, X. Chen, G. Levkowitz, D. Karunagaran, S. Lavi, B.J. Ratzkin, Y. Yarden, A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor, Mol. Cell. Biol. 16 (1996) 5276-5287.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 14
    • 0030973939 scopus 로고    scopus 로고
    • Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein
    • S.L. Sierke, K. Cheng, H.H. Kim, J.G. Koland, Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein, Biochem. J. 322 (Pt. 3) (1997) 757-763.
    • (1997) Biochem. J. , vol.322 , Issue.PART. 3 , pp. 757-763
    • Sierke, S.L.1    Cheng, K.2    Kim, H.H.3    Koland, J.G.4
  • 15
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
    • I. Alroy, Y. Yarden, The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions, FEBS Lett. 410 (1997) 83-86.
    • (1997) FEBS Lett , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 16
    • 0036056156 scopus 로고    scopus 로고
    • Cancer cell motility-on the road from c-erbB-2 receptor steered signaling to actin reorganization
    • J.C. Feldner, B.H. Brandt, Cancer cell motility-on the road from c-erbB-2 receptor steered signaling to actin reorganization, Exp. Cell Res. 272 (2002) 93-108.
    • (2002) Exp. Cell Res. , vol.272 , pp. 93-108
    • Feldner, J.C.1    Brandt, B.H.2
  • 18
    • 0021705725 scopus 로고
    • Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines
    • Y.H. Xu, N. Richert, S. Ito, G.T. Merlino, I. Pastan, Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines, Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 7308-7312.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 7308-7312
    • Xu, Y.H.1    Richert, N.2    Ito, S.3    Merlino, G.T.4    Pastan, I.5
  • 20
    • 0021154199 scopus 로고
    • Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells
    • Y.H. Xu, S. Ishii, A.J. Clark, M. Sullivan, R.K. Wilson, D.P. Ma, B.A. Roe, G.T. Merlino, I. Pastan, Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells, Nature 309 (1984) 806-810.
    • (1984) Nature , vol.309 , pp. 806-810
    • Xu, Y.H.1    Ishii, S.2    Clark, A.J.3    Sullivan, M.4    Wilson, R.K.5    Ma, D.P.6    Roe, B.A.7    Merlino, G.T.8    Pastan, I.9
  • 21
    • 37049185280 scopus 로고
    • Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells
    • G.T. Merlino, Y.H. Xu, S. Ishii, A.J. Clark, K. Semba, K. Toyoshima, T. Yamamoto, I. Pastan, Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells, Science 224 (1984) 417-419.
    • (1984) Science , vol.224 , pp. 417-419
    • Merlino, G.T.1    Xu, Y.H.2    Ishii, S.3    Clark, A.J.4    Semba, K.5    Toyoshima, K.6    Yamamoto, T.7    Pastan, I.8
  • 22
    • 0021257637 scopus 로고
    • Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells
    • C.R. Lin, W.S. Chen, W. Kruiger, L.S. Stolarsky, W. Weber, R.M. Evans, I.M. Verma, G.N. Gill, M.G. Rosenfeld, Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells, Science 224 (1984) 843-848.
    • (1984) Science , vol.224 , pp. 843-848
    • Lin, C.R.1    Chen, W.S.2    Kruiger, W.3    Stolarsky, L.S.4    Weber, W.5    Evans, R.M.6    Verma, I.M.7    Gill, G.N.8    Rosenfeld, M.G.9
  • 26
    • 0033841640 scopus 로고    scopus 로고
    • Co-expression of epidermal growth factor receptor and transforming growth factor-alpha is independent of ras mutations in lung adenocarcinoma
    • E.T. Hsieh, F.A. Shepherd, M.S. Tsao, Co-expression of epidermal growth factor receptor and transforming growth factor-alpha is independent of ras mutations in lung adenocarcinoma, Lung Cancer 29 (2000) 151-157.
    • (2000) Lung Cancer , vol.29 , pp. 151-157
    • Hsieh, E.T.1    Shepherd, F.A.2    Tsao, M.S.3
  • 27
    • 0032944473 scopus 로고    scopus 로고
    • Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells
    • D. Seth, K. Shaw, J. Jazayeri, P.J. Leedman, Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells, Br. J. Cancer 80 (1999) 657-669.
    • (1999) Br. J. Cancer , vol.80 , pp. 657-669
    • Seth, D.1    Shaw, K.2    Jazayeri, J.3    Leedman, P.J.4
  • 28
    • 0032780384 scopus 로고    scopus 로고
    • Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours
    • Y.C. Cai, Z. Jiang, F. Vittimberga, X. Xu, L. Savas, B. Woda, M. Callery, B. Banner, Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours, Virchows Arch. 435 (1999) 112-115.
    • (1999) Virchows Arch , vol.435 , pp. 112-115
    • Cai, Y.C.1    Jiang, Z.2    Vittimberga, F.3    Xu, X.4    Savas, L.5    Woda, B.6    Callery, M.7    Banner, B.8
  • 29
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • F. Ciardiello, G. Tortora, EGFR antagonists in cancer treatment, N. Engl. J. Med. 358 (2008) 1160-1174.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 30
    • 0019474922 scopus 로고
    • Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
    • C. Shih, L.C. Padhy, M. Murray, R.A. Weinberg, Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts, Nature 290 (1981) 261-264.
    • (1981) Nature , vol.290 , pp. 261-264
    • Shih, C.1    Padhy, L.C.2    Murray, M.3    Weinberg, R.A.4
  • 33
    • 0022406444 scopus 로고
    • Amplification of a novel v-erbB-related gene in a human mammary carcinoma
    • C.R. King, M.H. Kraus, S.A. Aaronson, Amplification of a novel v-erbB-related gene in a human mammary carcinoma, Science 229 (1985) 974-976.
    • (1985) Science , vol.229 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 34
    • 34547871259 scopus 로고    scopus 로고
    • Targeting HER proteins in cancer therapy and the role of the non-target HER3
    • A.C. Hsieh, M.M. Moasser, Targeting HER proteins in cancer therapy and the role of the non-target HER3, Br. J. Cancer 97 (2007) 453-457.
    • (2007) Br. J. Cancer , vol.97 , pp. 453-457
    • Hsieh, A.C.1    Moasser, M.M.2
  • 35
    • 0023713558 scopus 로고
    • Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    • W.J. Muller, E. Sinn, P.K. Pattengale, R. Wallace, P. Leder, Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene, Cell 54 (1988) 105-115.
    • (1988) Cell , vol.54 , pp. 105-115
    • Muller, W.J.1    Sinn, E.2    Pattengale, P.K.3    Wallace, R.4    Leder, P.5
  • 36
    • 0024405949 scopus 로고
    • Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene
    • L. Bouchard, L. Lamarre, P.J. Tremblay, P. Jolicoeur, Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene, Cell 57 (1989) 931-936.
    • (1989) Cell , vol.57 , pp. 931-936
    • Bouchard, L.1    Lamarre, L.2    Tremblay, P.J.3    Jolicoeur, P.4
  • 38
    • 0027986757 scopus 로고
    • Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors
    • P.M. Siegel, D.L. Dankort, W.R. Hardy, W.J. Muller, Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors, Mol. Cell. Biol. 14 (1994) 7068-7077.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7068-7077
    • Siegel, P.M.1    Dankort, D.L.2    Hardy, W.R.3    Muller, W.J.4
  • 39
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • S.K. Muthuswamy, D. Li, S. Lelievre, M.J. Bissell, J.S. Brugge, ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini, Nat. Cell Biol. 3 (2001) 785-792.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 40
    • 0026545620 scopus 로고
    • The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast
    • E. Liu, A. Thor, M. He, M. Barcos, B.M. Ljung, C. Benz, The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast, Oncogene 7 (1992) 1027-1032.
    • (1992) Oncogene , vol.7 , pp. 1027-1032
    • Liu, E.1    Thor, A.2    He, M.3    Barcos, M.4    Ljung, B.M.5    Benz, C.6
  • 41
    • 0021868251 scopus 로고
    • Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells
    • J. Blay, K.D. Brown, Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells, J. Cell. Physiol. 124 (1985) 107-112.
    • (1985) J. Cell. Physiol. , vol.124 , pp. 107-112
    • Blay, J.1    Brown, K.D.2
  • 42
    • 0023624729 scopus 로고
    • Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor
    • Y. Barrandon, H. Green, Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor, Cell 50 (1987) 1131-1137.
    • (1987) Cell , vol.50 , pp. 1131-1137
    • Barrandon, Y.1    Green, H.2
  • 43
    • 0030271724 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) increases the in vitro invasion, motility and adhesion interactions of the primary renal carcinoma cell line, A704
    • J.T. Price, H.M. Wilson, N.E. Haites, Epidermal growth factor (EGF) increases the in vitro invasion, motility and adhesion interactions of the primary renal carcinoma cell line, A704, Eur. J. Cancer 32A (1996) 1977-1982.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1977-1982
    • Price, J.T.1    Wilson, H.M.2    Haites, N.E.3
  • 44
    • 0031470359 scopus 로고    scopus 로고
    • Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro
    • A. El-Obeid, E. Bongcam-Rudloff, M. Sorby, A. Ostman, M. Nister, B. Westermark, Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro, Cancer Res. 57 (1997) 5598-5604.
    • (1997) Cancer Res , vol.57 , pp. 5598-5604
    • El-Obeid, A.1    Bongcam-Rudloff, E.2    Sorby, M.3    Ostman, A.4    Nister, M.5    Westermark, B.6
  • 45
    • 0030879101 scopus 로고    scopus 로고
    • Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis
    • F.J. Xu, S. Stack, C. Boyer, K. OBriant, R. Whitaker, G.B. Mills, Y.H. Yu, R.C. Bast Jr., Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis, Clin. Cancer Res. 3 (1997) 1629-1634.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1629-1634
    • Xu, F.J.1    Stack, S.2    Boyer, C.3    OBriant, K.4    Whitaker, R.5    Mills, G.B.6    Yu, Y.H.7    Bast Jr, R.C.8
  • 46
    • 0029960701 scopus 로고    scopus 로고
    • EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells
    • T. Turner, P. Chen, L.J. Goodly, A. Wells, EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells, Clin. Exp. Metastasis 14 (1996) 409-418.
    • (1996) Clin. Exp. Metastasis , vol.14 , pp. 409-418
    • Turner, T.1    Chen, P.2    Goodly, L.J.3    Wells, A.4
  • 47
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • C.J. Bruns, C.C. Solorzano, M.T. Harbison, S. Ozawa, R. Tsan, D. Fan, J. Abbruzzese, P. Traxler, E. Buchdunger, R. Radinsky, I.J. Fidler, Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma, Cancer Res. 60 (2000) 2926-2935.
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3    Ozawa, S.4    Tsan, R.5    Fan, D.6    Abbruzzese, J.7    Traxler, P.8    Buchdunger, E.9    Radinsky, R.10    Fidler, I.J.11
  • 48
    • 31544468879 scopus 로고    scopus 로고
    • Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
    • C. Xue, J. Wyckoff, F. Liang, M. Sidani, S. Violini, K.L. Tsai, Z.Y. Zhang, E. Sahai, J. Condeelis, J.E. Segall, Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis, Cancer Res. 66 (2006) 192-197.
    • (2006) Cancer Res , vol.66 , pp. 192-197
    • Xue, C.1    Wyckoff, J.2    Liang, F.3    Sidani, M.4    Violini, S.5    Tsai, K.L.6    Zhang, Z.Y.7    Sahai, E.8    Condeelis, J.9    Segall, J.E.10
  • 52
    • 0028089832 scopus 로고
    • Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
    • P. Chen, H. Xie, M.C. Sekar, K. Gupta, A. Wells, Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement, J. Cell Biol. 127 (1994) 847-857.
    • (1994) J. Cell Biol. , vol.127 , pp. 847-857
    • Chen, P.1    Xie, H.2    Sekar, M.C.3    Gupta, K.4    Wells, A.5
  • 54
    • 33744912774 scopus 로고    scopus 로고
    • Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors
    • L. Zhan, B. Xiang, S.K. Muthuswamy, Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors, Cancer Res. 66 (2006) 5201-5208.
    • (2006) Cancer Res , vol.66 , pp. 5201-5208
    • Zhan, L.1    Xiang, B.2    Muthuswamy, S.K.3
  • 55
    • 0029758126 scopus 로고    scopus 로고
    • A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility
    • P. Chen, J.E. Murphy-Ullrich, A. Wells, A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility, J. Cell Biol. 134 (1996) 689-698.
    • (1996) J. Cell Biol. , vol.134 , pp. 689-698
    • Chen, P.1    Murphy-Ullrich, J.E.2    Wells, A.3
  • 56
    • 0031908252 scopus 로고    scopus 로고
    • EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells
    • A.Y. Chan, S. Raft, M. Bailly, J.B. Wyckoff, J.E. Segall, J.S. Condeelis, EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells, J. Cell. Sci. 111 (Pt. 2) (1998) 199-211.
    • (1998) J. Cell. Sci. , vol.111 , Issue.PART. 2 , pp. 199-211
    • Chan, A.Y.1    Raft, S.2    Bailly, M.3    Wyckoff, J.B.4    Segall, J.E.5    Condeelis, J.S.6
  • 57
    • 0034614942 scopus 로고    scopus 로고
    • Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion
    • A.Y. Chan, M. Bailly, N. Zebda, J.E. Segall, J.S. Condeelis, Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion, J. Cell Biol.148 (2000) 531-542.
    • (2000) J. Cell Biol. , vol.148 , pp. 531-542
    • Chan, A.Y.1    Bailly, M.2    Zebda, N.3    Segall, J.E.4    Condeelis, J.S.5
  • 60
    • 0029824114 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification
    • T.G. Ram, S.P. Ethier, Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification, Cell Growth Differ. 7 (1996) 551-561.
    • (1996) Cell Growth Differ , vol.7 , pp. 551-561
    • Ram, T.G.1    Ethier, S.P.2
  • 62
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • L. Adam, R. Vadlamudi, S.B. Kondapaka, J. Chernoff, J. Mendelsohn, R. Kumar, Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase, J. Biol. Chem. 273 (1998) 28238-28246.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 63
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • L. Adam, R. Vadlamudi, M. Mandal, J. Chernoff, R. Kumar, Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1, J. Biol. Chem. 275 (2000) 12041-12050.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 64
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • R.K. Vadlamudi, L. Adam, R.A. Wang, M. Mandal, D. Nguyen, A. Sahin, J. Chernoff, M.C. Hung, R. Kumar, Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells, J. Biol. Chem. 275 (2000) 36238-36244.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5    Sahin, A.6    Chernoff, J.7    Hung, M.C.8    Kumar, R.9
  • 65
    • 0034671927 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis
    • R. Bagheri-Yarmand, R.K. Vadlamudi, R.A. Wang, J. Mendelsohn, R. Kumar, Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis, J. Biol. Chem. 275 (2000) 39451-39457.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39451-39457
    • Bagheri-Yarmand, R.1    Vadlamudi, R.K.2    Wang, R.A.3    Mendelsohn, J.4    Kumar, R.5
  • 66
    • 0033194037 scopus 로고    scopus 로고
    • Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
    • D.C. Edwards, L.C. Sanders, G.M. Bokoch, G.N. Gill, Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics, Nat. Cell Biol. 1 (1999) 253-259.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 253-259
    • Edwards, D.C.1    Sanders, L.C.2    Bokoch, G.M.3    Gill, G.N.4
  • 67
    • 0032586952 scopus 로고    scopus 로고
    • Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase
    • M.A. Adelsman, J.B. McCarthy, Y. Shimizu, Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase, Mol. Biol. Cell 10 (1999) 2861-2878.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2861-2878
    • Adelsman, M.A.1    McCarthy, J.B.2    Shimizu, Y.3
  • 69
    • 0034466985 scopus 로고    scopus 로고
    • Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer
    • J.S. Biscardi, R.C. Ishizawar, C.M. Silva, S.J. Parsons, Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer, Breast Cancer Res. 2 (2000) 203-210.
    • (2000) Breast Cancer Res , vol.2 , pp. 203-210
    • Biscardi, J.S.1    Ishizawar, R.C.2    Silva, C.M.3    Parsons, S.J.4
  • 70
    • 27844600580 scopus 로고    scopus 로고
    • The c-Src tyrosine kinase associates with the catalyticdomain of ErbB-2: implications for ErbB-2 mediated signaling and transformation
    • H. Kim, R. Chan, D.L. Dankort, D. Zuo, M. Najoukas, M. Park, W.J. Muller, The c-Src tyrosine kinase associates with the catalyticdomain of ErbB-2: implications for ErbB-2 mediated signaling and transformation, Oncogene 24 (2005) 7599-7607.
    • (2005) Oncogene , vol.24 , pp. 7599-7607
    • Kim, H.1    Chan, R.2    Dankort, D.L.3    Zuo, D.4    Najoukas, M.5    Park, M.6    Muller, W.J.7
  • 71
    • 0028047315 scopus 로고
    • Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
    • S.K. Muthuswamy, P.M. Siegel, D.L. Dankort, M.A. Webster, W.J. Muller, Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity, Mol. Cell. Biol. 14 (1994) 735-743.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 735-743
    • Muthuswamy, S.K.1    Siegel, P.M.2    Dankort, D.L.3    Webster, M.A.4    Muller, W.J.5
  • 72
    • 0029165834 scopus 로고
    • Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor
    • S.K. Muthuswamy, W.J. Muller, Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor, Oncogene 11 (1995) 271-279.
    • (1995) Oncogene , vol.11 , pp. 271-279
    • Muthuswamy, S.K.1    Muller, W.J.2
  • 73
    • 6844259884 scopus 로고    scopus 로고
    • Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential
    • W. Mao, R. Irby, D. Coppola, L. Fu, M. Wloch, J. Turner, H. Yu, R. Garcia, R. Jove, T.J. Yeatman, Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential, Oncogene 15 (1997) 3083-3090.
    • (1997) Oncogene , vol.15 , pp. 3083-3090
    • Mao, W.1    Irby, R.2    Coppola, D.3    Fu, L.4    Wloch, M.5    Turner, J.6    Yu, H.7    Garcia, R.8    Jove, R.9    Yeatman, T.J.10
  • 74
    • 16444382989 scopus 로고    scopus 로고
    • ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis
    • M. Tan, P. Li, K.S. Klos, J. Lu, K.H. Lan, Y. Nagata, D. Fang, T. Jing, D. Yu, ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis, Cancer Res. 65 (2005) 1858-1867.
    • (2005) Cancer Res , vol.65 , pp. 1858-1867
    • Tan, M.1    Li, P.2    Klos, K.S.3    Lu, J.4    Lan, K.H.5    Nagata, Y.6    Fang, D.7    Jing, T.8    Yu, D.9
  • 75
    • 34249325876 scopus 로고    scopus 로고
    • Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior
    • M. Dimri, M. Naramura, L. Duan, J. Chen, C. Ortega-Cava, G. Chen, R. Goswami, N. Fernandes, Q. Gao, G.P. Dimri, V. Band, H. Band, Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior, Cancer Res. 67 (2007) 4164-4172.
    • (2007) Cancer Res , vol.67 , pp. 4164-4172
    • Dimri, M.1    Naramura, M.2    Duan, L.3    Chen, J.4    Ortega-Cava, C.5    Chen, G.6    Goswami, R.7    Fernandes, N.8    Gao, Q.9    Dimri, G.P.10    Band, V.11    Band, H.12
  • 78
    • 34249059285 scopus 로고    scopus 로고
    • Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells
    • G. Kallergi, D. Mavroudis, V. Georgoulias, C. Stournaras, Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells, Mol. Med. 13 (2007) 79-88.
    • (2007) Mol. Med. , vol.13 , pp. 79-88
    • Kallergi, G.1    Mavroudis, D.2    Georgoulias, V.3    Stournaras, C.4
  • 79
    • 33744936606 scopus 로고    scopus 로고
    • Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors
    • M. Tan, P. Li, M. Sun, G. Yin, D. Yu, Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors, Oncogene 25 (2006) 3286-3295.
    • (2006) Oncogene , vol.25 , pp. 3286-3295
    • Tan, M.1    Li, P.2    Sun, M.3    Yin, G.4    Yu, D.5
  • 80
    • 0842320996 scopus 로고    scopus 로고
    • Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells
    • S.E. Seton-Rogers, Y. Lu, L.M. Hines, M. Koundinya, J. LaBaer, S.K. Muthuswamy, J.S. Brugge, Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells, Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 1257-1262.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 1257-1262
    • Seton-Rogers, S.E.1    Lu, Y.2    Hines, L.M.3    Koundinya, M.4    LaBaer, J.5    Muthuswamy, S.K.6    Brugge, J.S.7
  • 82
    • 2642521235 scopus 로고    scopus 로고
    • Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility
    • Y. Ueda, S. Wang, N. Dumont, J.Y. Yi, Y. Koh, C.L. Arteaga, Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility, J. Biol. Chem. 279 (2004) 24505-24513.
    • (2004) J. Biol. Chem. , vol.279 , pp. 24505-24513
    • Ueda, Y.1    Wang, S.2    Dumont, N.3    Yi, J.Y.4    Koh, Y.5    Arteaga, C.L.6
  • 83
    • 43249109660 scopus 로고    scopus 로고
    • Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion
    • J.J. Northey, J. Chmielecki, E. Ngan, C. Russo, M.G. Annis, W.J. Muller, P.M. Siegel, Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion, Mol. Cell. Biol. 28 (2008) 3162-3176.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 3162-3176
    • Northey, J.J.1    Chmielecki, J.2    Ngan, E.3    Russo, C.4    Annis, M.G.5    Muller, W.J.6    Siegel, P.M.7
  • 84
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • A.J. Ridley, A. Hall, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell 70 (1992) 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 85
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • A.J. Ridley, H.F. Paterson, C.L. Johnston, D. Diekmann, A. Hall, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell 70 (1992) 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 87
    • 0032539001 scopus 로고    scopus 로고
    • The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells
    • A. Malliri, M. Symons, R.F. Hennigan, A.F. Hurlstone, R.F. Lamb, T. Wheeler, B.W. Ozanne, The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells, J. Cell Biol. 143 (1998) 1087-1099.
    • (1998) J. Cell Biol. , vol.143 , pp. 1087-1099
    • Malliri, A.1    Symons, M.2    Hennigan, R.F.3    Hurlstone, A.F.4    Lamb, R.F.5    Wheeler, T.6    Ozanne, B.W.7
  • 88
    • 33645575688 scopus 로고    scopus 로고
    • Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
    • T. Murai, T. Miyauchi, T. Yanagida, Y. Sako, Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10, Biochem. J. 395 (2006) 65-71.
    • (2006) Biochem. J. , vol.395 , pp. 65-71
    • Murai, T.1    Miyauchi, T.2    Yanagida, T.3    Sako, Y.4
  • 89
    • 0037352352 scopus 로고    scopus 로고
    • p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion
    • K.M. Woods Ignatoski, N.K. Grewal, S. Markwart, D.L. Livant, S.P. Ethier, p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion, Neoplasia 5 (2003) 128-134.
    • (2003) Neoplasia , vol.5 , pp. 128-134
    • Woods Ignatoski, K.M.1    Grewal, N.K.2    Markwart, S.3    Livant, D.L.4    Ethier, S.P.5
  • 90
    • 0037452071 scopus 로고    scopus 로고
    • Adaptation of core mechanisms to generate cell polarity
    • W.J. Nelson, Adaptation of core mechanisms to generate cell polarity, Nature 422 (2003) 766-774.
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 91
  • 92
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: lessons in polarity
    • A. Suzuki, S. Ohno, The PAR-aPKC system: lessons in polarity, J. Cell. Sci. 119 (2006) 979-987.
    • (2006) J. Cell. Sci. , vol.119 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2
  • 94
    • 33746615950 scopus 로고    scopus 로고
    • PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells
    • M. Elbert, D. Cohen, A. Musch, PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells, Mol. Biol. Cell 17 (2006) 3345-3355.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3345-3355
    • Elbert, M.1    Cohen, D.2    Musch, A.3
  • 97
    • 34547590898 scopus 로고    scopus 로고
    • Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization
    • H.M. Phillips, H.J. Rhee, J.N. Murdoch, V. Hildreth, J.D. Peat, R.H. Anderson, A.J. Copp, B. Chaudhry, D.J. Henderson, Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization, Circ. Res. 101 (2007) 137-145.
    • (2007) Circ. Res. , vol.101 , pp. 137-145
    • Phillips, H.M.1    Rhee, H.J.2    Murdoch, J.N.3    Hildreth, V.4    Peat, J.D.5    Anderson, R.H.6    Copp, A.J.7    Chaudhry, B.8    Henderson, D.J.9
  • 98
    • 0034617129 scopus 로고    scopus 로고
    • Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    • D. Bilder, M. Li, N. Perrimon, Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors, Science 289 (2000) 113-116.
    • (2000) Science , vol.289 , pp. 113-116
    • Bilder, D.1    Li, M.2    Perrimon, N.3
  • 99
    • 0242641565 scopus 로고    scopus 로고
    • Richardson, scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    • A.M. Brumby, H.E. Richardson, scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila, EMBO J. 22 (2003) 5769-5779.
    • (2003) EMBO J , vol.22 , pp. 5769-5779
    • Brumby, A.M.H.E.1
  • 100
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • R.A. Pagliarini, T. Xu, A genetic screen in Drosophila for metastatic behavior, Science 302 (2003) 1227-1231.
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 101
    • 53649108148 scopus 로고    scopus 로고
    • Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling
    • L.E. Dow, I.A. Elsum, C.L. King, K.M. Kinross, H.E. Richardson, P.O. Humbert, Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling, Oncogene (2008).
    • (2008) Oncogene
    • Dow, L.E.1    Elsum, I.A.2    King, C.L.3    Kinross, K.M.4    Richardson, H.E.5    Humbert, P.O.6
  • 102
    • 0033619139 scopus 로고    scopus 로고
    • Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation
    • D. Gardiol, C. Kuhne, B. Glaunsinger, S.S. Lee, R. Javier, L. Banks, Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation, Oncogene 18 (1999) 5487-5496.
    • (1999) Oncogene , vol.18 , pp. 5487-5496
    • Gardiol, D.1    Kuhne, C.2    Glaunsinger, B.3    Lee, S.S.4    Javier, R.5    Banks, L.6
  • 103
    • 0033776810 scopus 로고    scopus 로고
    • Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
    • S. Nakagawa, J.M. Huibregtse, Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase, Mol. Cell. Biol. 20 (2000) 8244-8253.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8244-8253
    • Nakagawa, S.1    Huibregtse, J.M.2
  • 104
    • 33747465415 scopus 로고    scopus 로고
    • Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression
    • D. Gardiol, A. Zacchi, F. Petrera, G. Stanta, L. Banks, Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression, Int. J. Cancer 119 (2006) 1285-1290.
    • (2006) Int. J. Cancer , vol.119 , pp. 1285-1290
    • Gardiol, D.1    Zacchi, A.2    Petrera, F.3    Stanta, G.4    Banks, L.5
  • 111
    • 33750489040 scopus 로고    scopus 로고
    • Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling
    • Y. Wang, D. Du, L. Fang, G. Yang, C. Zhang, R. Zeng, A. Ullrich, F. Lottspeich, Z. Chen, Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling, EMBO J. 25 (2006) 5058-5070.
    • (2006) EMBO J , vol.25 , pp. 5058-5070
    • Wang, Y.1    Du, D.2    Fang, L.3    Yang, G.4    Zhang, C.5    Zeng, R.6    Ullrich, A.7    Lottspeich, F.8    Chen, Z.9
  • 112
    • 0033538025 scopus 로고    scopus 로고
    • Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
    • T. Muller, A. Choidas, E. Reichmann, A. Ullrich, Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration, J. Biol. Chem. 274 (1999) 10173-10183.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10173-10183
    • Muller, T.1    Choidas, A.2    Reichmann, E.3    Ullrich, A.4
  • 113
    • 0345736990 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    • Z. Lu, S. Ghosh, Z.Wang, T. Hunter, Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion, Cancer Cell 4 (2003) 499-515.
    • (2003) Cancer Cell , vol.4 , pp. 499-515
    • Lu, Z.1    Ghosh, S.2    Wang, Z.3    Hunter, T.4
  • 114
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • B. Ozdamar, R. Bose, M. Barrios-Rodiles, H.R. Wang, Y. Zhang, J.L. Wrana, Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity, Science 307 (2005) 1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 115
    • 39149135251 scopus 로고    scopus 로고
    • Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
    • X.Wang, J. Nie, Q. Zhou,W. Liu, F. Zhu,W. Chen, H. Mao, N. Luo, X. Dong, X. Yu, Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells, Biochim. Biophys. Acta 1782 (2008) 51-59.
    • (2008) Biochim. Biophys. Acta , vol.1782 , pp. 51-59
    • Wang, X.1    Nie, J.2    Zhou, Q.3    Liu, W.4    Zhu, F.5    Chen, W.6    Mao, H.7    Luo, N.8    Dong, X.9    Yu, X.10
  • 116
    • 0035943401 scopus 로고    scopus 로고
    • Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    • S. Etienne-Manneville, A. Hall, Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta, Cell 106 (2001) 489-498.
    • (2001) Cell , vol.106 , pp. 489-498
    • Etienne-Manneville, S.1    Hall, A.2
  • 117
    • 0037434790 scopus 로고    scopus 로고
    • Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
    • S. Etienne-Manneville, A. Hall, Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity, Nature 421 (2003) 753-756.
    • (2003) Nature , vol.421 , pp. 753-756
    • Etienne-Manneville, S.1    Hall, A.2
  • 119
    • 33845472291 scopus 로고    scopus 로고
    • Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration
    • N. Osmani, N. Vitale, J.P. Borg, S. Etienne-Manneville, Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration, Curr. Biol. 16 (2006) 2395-2405.
    • (2006) Curr. Biol , vol.16 , pp. 2395-2405
    • Osmani, N.1    Vitale, N.2    Borg, J.P.3    Etienne-Manneville, S.4


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