Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways

Journal of General Physiology

Volumn 124, Issue 6, 2004, Pages 719-727

  Wei, Yuan ^a   Lin, Dao Hong ^a,b   Kemp, Rowena ^a   Yaddanapudi, Ganesh S S ^c   Nasjletti, Alberto ^a   Falck, John R ^c   Wang, Wen Hui ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cortical collecting duct; ENaC; Epoxyeicosatrienoic acid; MS PPOH; Na reabsorption

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; AMILORIDE; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 2C23; ENZYME INHIBITOR; EPOXYICOSATRIENOIC ACID; INDOMETACIN; N METHYLSULFONYL 12,12 DIBROMODODEC 11 ENAMIDE; N METHYLSULFONYL 6 (PROPARGYLOXYPHENYL)HEXANAMIDE; PROSTAGLANDIN SYNTHASE INHIBITOR; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; EPITHELIAL SODIUM CHANNEL; GAS CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY CORTEX; MASS SPECTROMETRY; NONHUMAN; PATCH CLAMP; RAT; SODIUM ABSORPTION;

ANIMALS; ARACHIDONIC ACID; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL SODIUM CHANNEL; FEMALE; ION CHANNEL GATING; KIDNEY TUBULES, COLLECTING; MALE; MEMBRANE POTENTIALS; OXYGENASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SODIUM; SODIUM CHANNELS;

EID: 10344261424     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200409140     Document Type: Article

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