Zinc-induced self-association of complement C3b and factor H: Implications for inflammation and age-related macular degeneration

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19197-19210

  Nan, Ruodan ^a   Tetchner, Stuart ^a   Rodriguez, Elizabeth ^a   Pao, Po Jung ^a   Gor, Jayesh ^a   Lengyel, Imre ^b   Perkins, Stephen J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; ANALYTICAL ULTRACENTRIFUGATION; COMPUTATIONAL PREDICTIONS; INITIAL DEVELOPMENT; RELATIVE POSITIONS; SELF-ASSOCIATIONS; SPONTANEOUS HYDROLYSIS; ZINC-BINDING SITES;

ASSOCIATION REACTIONS; DEPOSITS; OLIGOMERS; OPHTHALMOLOGY; PROTEINS;

ZINC;

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3C; COMPLEMENT COMPONENT C3D; COMPLEMENT FACTOR H; FIBRINOGEN; ZINC;

ARTICLE; BINDING SITE; COMPLEX FORMATION; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIGH RISK PATIENT; HUMAN; INFLAMMATION; PATHOGENESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN INTERACTION; RADIATION SCATTERING; RETINA MACULA AGE RELATED DEGENERATION; RETINA PIGMENT EPITHELIOPATHY; ULTRACENTRIFUGATION;

AGE-RELATED MACULAR DEGENERATION; ANALYTICAL ULTRACENTRIFUGATION; COMPLEMENT; INFLAMMATION; X-RAY SCATTERING; ZINC;

BINDING SITES; COMPLEMENT C3B; COMPLEMENT FACTOR H; COMPUTER SIMULATION; EPITHELIAL CELLS; HUMANS; INFLAMMATION; MACULAR DEGENERATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RETINA; RETINAL PIGMENT EPITHELIUM; SCATTERING, RADIATION; ULTRACENTRIFUGATION; X-RAYS; ZINC;

EID: 84879582831     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.476143     Document Type: Article

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