Human complement factor I does not require cofactors for cleavage of synthetic substrates

Journal of Immunology

Volumn 173, Issue 1, 2004, Pages 367-375

  Tsiftsoglou, Stefanos A ^a   Sim, Robert B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; 7 AMINO 4 METHYLCOUMARIN; BENZENESULFONIC ACID DERIVATIVE; BENZYLOXYCARBONYL DEXTRO PHENYLALANYLPROLINE METHOXYPROPYLBOROGLYCINEPINANEDIOL ESTER; BORON DERIVATIVE; CHROMIUM; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C4 BINDING PROTEIN; COMPLEMENT COMPONENT C4B; COMPLEMENT FACTOR H; COMPLEMENT FACTOR I; COMPLEMENT INHIBITOR; COUMARIN DERIVATIVE; FLUORIDE; GLYCINE DERIVATIVE; IRON; MEMBRANE COFACTOR PROTEIN; METAL ION; SURAMIN; THROMBIN INHIBITOR; TRIPEPTIDE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; CATALYSIS; COMPLEMENT ACTIVATION; ENZYME SPECIFICITY; HUMAN; IONIC STRENGTH; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REACTION TIME;

EID: 2942709791     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.1.367     Document Type: Article

References (44)

1. Arlaud, G. J., J. E. Volanakis, N. M. Thielens, S. V. Narayana, V. Rossi, and Y. Xu. 1998. The atypical serine proteases of the complement system. Adv. Immunol. 69:249.
2. Sim, R. B., and S. A. Tsiftsoglou. 2004. Proteases of the complement system. Biochem. Soc. Trans. 32:21.
3. Sim, R. B. 1993. Activators and Inhibitors of Complement. Kluwer Academic Publishers, Dordrecht.
4. Law, S. K. A., and K. B. M. Reid. 1995. Complement. IRL Press Ltd., Oxford.
5. Soames, C. J., and R. B. Sim. 1997. Interactions between human complement components factor H, factor I and C3b. Biochem. J. 326:553.
6. Catterall, C. F., A. Lyons, R. B. Sim, A. J. Day, and T. J. Harris. 1987. Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones. Biochem. J. 242:849.
7. Goldberger, G., G. A. Bruns, M. Rits, M. D. Edge, and D. J. Kwiatkowski. 1987. Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4. J. Biol. Chem. 262:10065.
8. Goldberger, G., M. A. Arnaout, D. Aden, R. Kay, M. Rits, and H. R. Colten. 1984. Biosynthesis and postsynthetic processing of human C3b/C4b inactivator (factor I) in three hepatoma cell lines. J. Biol. Chem. 259:6492.
9. Ritchie, G. E., B. E. Moffatt, R. B. Sim, B. P. Morgan, R. A. Dwek, and P. M. Rudd. 2002. Glycosylation and the complement system. Chem. Rev. 102:305.
10. Kunnath-Muglia, L. M., G. H. Chang, R. B. Sim, A. J. Day, and R. A. Ezekowitz. 1993. Characterization of Xenopus laevis complement factor I structure: conservation of modular structure except for an unusual insert not present in human factor I. Mol. Immunol. 30:1249.
11. Kam, C. M., T. J. Oglesby, M. K. Pangbum, J. E. Volanakis, and J. C. Powers. 1992. Substituted isocoumarins as inhibitors of complement serine proteases. J. Immunol. 149:163.
12. Jing, H., K. J. Macon, D. Moore, L. J. DeLucas, J. E. Volanakis, and S. V. Narayana. 1999. Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. EMBO J. 18:804.
13. Xu, Y., S. V. Narayana, and J. E. Volanakis. 2001. Structural biology of the alternative pathway convertase. Immunol. Rev. 180:123.
14. Kam, C. M., B. J. McRae, J. W. Harper, M. A. Niemann, J. E. Volanakis, and J. C. Powers. 1987. Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates. J. Biol. Chem. 262:3444.
15. Ekdahl, K. N., U. R. Nilsson, and B. Nilsson. 1990. Inhibition of factor I by diisopropylfluorophosphate: evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I. J. Immunol. 144:4269.
16. McRae, B. J., K. Kurachi, R. L. Heimark, K. Fujikawa, E. W. Davie, and J. C. Powers. 1981. Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates. Biochemistry 20:7196.
17. Kam, C. M., G. P. Vlasuk, D. E. Smith, K. E. Arcuri, and J. C. Powers. 1990. Thioester chromogenic substrates for human factor VIIa: substituted isocoumarins are inhibitors of factor VIIa and in vitro anticoagulants. Thromb. Haemost. 64:133.
18. Dodds, A. W. 1993. Small-scale preparation of complement components C3 and C4. Methods Enzymol. 223:46.
19. von Zabern, I., E. L. Bloom, V. Chu, and I. Gigli. 1982. The fourth component of human complement treated with amines or chaotropes or frozen-thawed (C4b-like C4): interaction with C4 binding protein and cleavage by C3b/C4b inactivator. J. Immunol. 128:1433.
20. Sim, R. B., A. J. Day, B. E. Moffatt, and M. Fontaine. 1993. Complement factor I and cofactors in control of complement system convertase enzymes. Methods Enzymol. 223:13.
21. Sim, R. B., and A. Reboul. 1981. Preparation and properties of human C1 inhibitor. Methods Enzymol. 80(Pt. C):43.
22. Pilatte, Y., C. H. Hammer, M. M. Frank, and L. F. Fries. 1989. A new simplified procedure for C1 inhibitor purification. A novel use for jacalin-agarose. J. Immunol. Methods 120:37.
23. Fraker, P. J., and J. C. Speck, Jr. 1978. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3α, 6α-diphenylglycoluril. Biochem. Biophys. Res. Commun. 80:849.
24. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
25. Fairbanks, G., T. L. Steck, and D. F. Wallach. 1971. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Biochemistry 10:2606.
26. Sim, E., and R. B. Sim. 1983. Enzymic assay of C3b receptor on intact cells and solubilized cells. Biochem. J. 210:567.
27. Crossley, L. G., and R. R. Porter. 1980. Purification of the human complement control protein C3b inactivator. Biochem. J. 191:173.
28. Sim, R. B., V. Malhotra, J. Ripoche, A. J. Day, K. J. Micklem, and E. Sim. 1986. Complement receptors and related complement control proteins. Biochem. Soc. Symp. 51:83.
29. Rupin, A., P. Mennecier, C. Lila, G. de Nanteuil, and T. J. Verbeuren. 1997. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor. Thromb. Haemost. 78:1221.
30. Fevig, J. M., J. Buriak, Jr., J. Cacciola, R. S. Alexander, C. A. Kettner, R. M. Knabb, J. R. Pruitt, P. C. Weber, and R. R. Wexler. 1998. Rational design of boropeptide thrombin inhibitors: β,β-dialkyl- phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile. Bioorg. Med. Chem. Lett. 8:301.
31. DiScipio, R. G. 1992. Ultrastructures and interactions of complement factors H and I. J. Immunol. 149:2592.
32. Perona, J. J., L. Hedstrom, W. J. Rutter, and R. J. Fletterick. 1995. Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry 34:1489.
33. Pangburn, M. K., and H. J. Muller-Eberhard. 1983. Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I. Biochemistry 22:178.
34. Patthy, L. 1990. Evolution of blood coagulation and fibrinolysis. Blood Coagul. Fibrinolysis 1:153.
35. Krem, M. M., T. Rose, and E. Di Cera. 2000. Sequence determinants of function and evolufion in serine proteases. Trends Cardiovasc. Med. 10:171.
36. +-induced allosteric regulation of catalytic activity in serine proteases. Proc. Natl. Acad. Sci. USA 93:10653.
37. Nakajima, M., A. DeChavigny, C. E. Johnson, J. Hamada, C. A. Stein, and G. L. Nicolson. 1991. Suramin. A potent inhibitor of melanoma heparanase and invasion. J. Biol. Chem. 266:9661.
38. Hawking, F. 1978. Suramin: with special reference to onchocerciasis. Adv. Pharmacol. Chemother. 15:289.
39. Cadene, M., J. Duranton, A. North, M. Si-Tahar, M. Chignard, and J. G. Bieth. 1997. Inhibition of neutrophil serine proteinases by suramin. J. Biol. Chem. 272:9950.
40. Fong, J. S., and R. A. Good. 1972. Suramin: a potent reversible and competitive inhibitor of complement systems. Clin. Exp. Immunol. 10:127.
41. Lachmann, P. J., P. Nicol, and W. P. Aston. 1973. Further studies on the C3b inactivator or conglutinogen activating factor (KAF). Immunochemistry 10:695.
42. Tamura, N., and R. A. Nelson, Jr. 1967. Three naturally-occurring inhibitors of components of complement in guinea pig and rabbit serum. J. Immunol. 99:582.
43. Cutting, W. C. 1964. Handbook of Pharmacology. Appleton-Century-Crofts, New York.
44. Brass, L. F., and S. J. Shattil. 1988. Inhibition of thrombin-induced platelet activation by leupeptin: implications for the participation of calpain in the initiation of platelet activation. J. Biol. Chem. 263:5210.