메뉴 건너뛰기




Volumn 94, Issue 1, 2013, Pages 159-170

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

Author keywords

Cell activation; Chemotaxis; Host defense peptide; Immunomodulation

Indexed keywords

ALPHA DEFENSIN; BACTENECIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CD11B ANTIGEN; CD18 ANTIGEN; CD64 ANTIGEN; CD66B ANTIGEN; CHEMOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HOST DEFENSE PEPTIDE; INTERLEUKIN 10; INTERLEUKIN 8; L SELECTIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MYELOPEROXIDASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN IDR 1002; PROTEIN IDR 1018; PROTEIN IDR HH2; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNTHETIC PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84879570321     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1012497     Document Type: Article
Times cited : (81)

References (61)
  • 2
    • 33847011002 scopus 로고    scopus 로고
    • Human defensins and cathelicidins in the skin: Beyond direct antimicrobial properties
    • Niyonsaba, F., Nagaoka, I., Ogawa, H. (2006) Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit. Rev. Immunol. 26, 545-576.
    • (2006) Crit. Rev. Immunol. , vol.26 , pp. 545-576
    • Niyonsaba, F.1    Nagaoka, I.2    Ogawa, H.3
  • 3
    • 69249155710 scopus 로고    scopus 로고
    • Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems
    • Niyonsaba, F., Nagaoka, I., Ogawa, H., Okumura, K. (2009) Multifunctional antimicrobial proteins and peptides: natural activators of immune systems. Curr. Pharm. Des. 15, 2393-2413.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 2393-2413
    • Niyonsaba, F.1    Nagaoka, I.2    Ogawa, H.3    Okumura, K.4
  • 4
    • 20544442905 scopus 로고    scopus 로고
    • Alarmins: Chemotactic activators of immune responses
    • Oppenheim, J. J., Yang, D. (2005) Alarmins: chemotactic activators of immune responses. Curr. Opin. Immunol. 17, 359-365.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 359-365
    • Oppenheim, J.J.1    Yang, D.2
  • 5
    • 85047685350 scopus 로고    scopus 로고
    • Using antimicrobial host defense peptides as anti-infective and immunomodulatory agents
    • Kruse, T., Kristensen, H. H. (2008) Using antimicrobial host defense peptides as anti-infective and immunomodulatory agents. Expert Rev. Anti Infect. Ther. 6, 887-895.
    • (2008) Expert Rev. Anti Infect. Ther. , vol.6 , pp. 887-895
    • Kruse, T.1    Kristensen, H.H.2
  • 6
    • 69249096200 scopus 로고    scopus 로고
    • The roles of antimicrobial peptides in innate host defense
    • Diamond, G., Beckloff, N., Weinberg, A., Kisich, K. O. (2009) The roles of antimicrobial peptides in innate host defense. Curr. Pharm. Des. 15, 2377-2392.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 2377-2392
    • Diamond, G.1    Beckloff, N.2    Weinberg, A.3    Kisich, K.O.4
  • 9
    • 79960936612 scopus 로고    scopus 로고
    • Multifunctional cationic host defence peptides and their clinical applications
    • Yeung, A. T., Gellatly, S. L., Hancock, R. E. W. (2011) Multifunctional cationic host defence peptides and their clinical applications. Cell. Mol. Life Sci. 68, 2161-2176.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 2161-2176
    • Yeung, A.T.1    Gellatly, S.L.2    Hancock, R.E.W.3
  • 10
    • 84858381864 scopus 로고    scopus 로고
    • Modulating immunity as a therapy for bacterial infections
    • Hancock, R. E. W., Nijnik, A., Philpott, D. J. (2012) Modulating immunity as a therapy for bacterial infections. Nat. Rev. Microbiol. 10, 243-254.
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 243-254
    • Hancock, R.E.W.1    Nijnik, A.2    Philpott, D.J.3
  • 11
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
    • Niyonsaba, F., Someya, A., Hirata, M., Ogawa, H., Nagaoka, I. (2001) Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur. J. Immunol. 31, 1066-1075.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3    Ogawa, H.4    Nagaoka, I.5
  • 13
  • 14
    • 69949086979 scopus 로고    scopus 로고
    • Potential of immunomodulatory host defense peptides as novel anti-infectives
    • Easton, D. M., Nijnik, A., Mayer, M. L., Hancock, R. E. W. (2009) Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol. 27, 582-590.
    • (2009) Trends Biotechnol. , vol.27 , pp. 582-590
    • Easton, D.M.1    Nijnik, A.2    Mayer, M.L.3    Hancock, R.E.W.4
  • 15
    • 67649494271 scopus 로고    scopus 로고
    • A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity
    • Kindrachuk, J., Jenssen, H., Elliott, M., Townsend, R., Nijnik, A., Lee, S. F., Gerdts, V., Babiuk, L. A., Halperin, S. A., Hancock, R. E. W. (2009) A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine 27, 4662-4671.
    • (2009) Vaccine , vol.27 , pp. 4662-4671
    • Kindrachuk, J.1    Jenssen, H.2    Elliott, M.3    Townsend, R.4    Nijnik, A.5    Lee, S.F.6    Gerdts, V.7    Babiuk, L.A.8    Halperin, S.A.9    Hancock, R.E.W.10
  • 16
    • 79952706041 scopus 로고    scopus 로고
    • Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations
    • Gracia, A., Polewicz, M., Halperin, S. A., Hancock, R. E. W., Potter, A. A., Babiuk, L. A., Gerdts, V. (2011) Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations. Vaccine 29, 1595-1604.
    • (2011) Vaccine , vol.29 , pp. 1595-1604
    • Gracia, A.1    Polewicz, M.2    Halperin, S.A.3    Hancock, R.E.W.4    Potter, A.A.5    Babiuk, L.A.6    Gerdts, V.7
  • 17
    • 84355161518 scopus 로고    scopus 로고
    • Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/ HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection
    • Brown, T. H., David, J., Acosta-Ramirez, E., Moore, J. M., Lee, S., Zhong, G., Hancock, R. E. W., Xing, Z., Halperin, S. A., Wang, J. (2012) Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/ HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection. Vaccine 30, 350-360.
    • (2012) Vaccine , vol.30 , pp. 350-360
    • Brown, T.H.1    David, J.2    Acosta-Ramirez, E.3    Moore, J.M.4    Lee, S.5    Zhong, G.6    Hancock, R.E.W.7    Xing, Z.8    Halperin, S.A.9    Wang, J.10
  • 20
    • 40849083459 scopus 로고    scopus 로고
    • The anti-infective peptide, innate defenseregulator peptide, stimulates neutrophil chemotaxis via a formyl peptide receptor
    • Lee, H. Y., Bae, Y. S. (2008) The anti-infective peptide, innate defenseregulator peptide, stimulates neutrophil chemotaxis via a formyl peptide receptor. Biochem. Biophys. Res. Commun. 369, 573-578.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 573-578
    • Lee, H.Y.1    Bae, Y.S.2
  • 21
    • 84866032735 scopus 로고    scopus 로고
    • Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin
    • Madera, L., Hancock, R. E. W. (2012) Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin. J. Innate Immun. 4, 553-568.
    • (2012) J. Innate Immun. , vol.4 , pp. 553-568
    • Madera, L.1    Hancock, R.E.W.2
  • 22
    • 30044434255 scopus 로고    scopus 로고
    • Systems biology of neutrophil differentiation and immune response
    • Theilgaard-Monch, K., Porse, B. T., Borregaard, N. (2006) Systems biology of neutrophil differentiation and immune response. Curr. Opin. Immunol. 18, 54-60.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 54-60
    • Theilgaard-Monch, K.1    Porse, B.T.2    Borregaard, N.3
  • 23
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • Rollins, B. J. (1997) Chemokines. Blood 90, 909-928.
    • (1997) Blood , vol.90 , pp. 909-928
    • Rollins, B.J.1
  • 24
    • 1642318503 scopus 로고    scopus 로고
    • Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-α-treated human neutrophils
    • Niyonsaba, F., Ogawa, H., Nagaoka, I. (2004) Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-α-treated human neutrophils. Immunology 111, 273-281.
    • (2004) Immunology , vol.111 , pp. 273-281
    • Niyonsaba, F.1    Ogawa, H.2    Nagaoka, I.3
  • 25
    • 36148980891 scopus 로고    scopus 로고
    • Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human α-defensins from neutrophils
    • Zheng, Y., Niyonsaba, F., Ushio, H., Nagaoka, I., Ikeda, S., Okumura, K., Ogawa, H. (2007) Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human α-defensins from neutrophils. Br. J. Dermatol. 157, 1124-1131.
    • (2007) Br. J. Dermatol. , vol.157 , pp. 1124-1131
    • Zheng, Y.1    Niyonsaba, F.2    Ushio, H.3    Nagaoka, I.4    Ikeda, S.5    Okumura, K.6    Ogawa, H.7
  • 26
    • 44849110924 scopus 로고    scopus 로고
    • Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation
    • Zheng, Y., Niyonsaba, F., Ushio, H., Ikeda, S., Nagaoka, I., Okumura, K., Ogawa, H. (2008) Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124, 357-367.
    • (2008) Immunology , vol.124 , pp. 357-367
    • Zheng, Y.1    Niyonsaba, F.2    Ushio, H.3    Ikeda, S.4    Nagaoka, I.5    Okumura, K.6    Ogawa, H.7
  • 28
    • 0001637870 scopus 로고
    • Permanent cell line expressing human factor VIII-related antigen established by hybridization
    • Edgell, C. J., McDonald, C. C., Graham, J. B. (1983) Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. USA 80, 3734-3737.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3734-3737
    • Edgell, C.J.1    McDonald, C.C.2    Graham, J.B.3
  • 29
    • 23844462182 scopus 로고    scopus 로고
    • Molecular mechanics and dynamics of leukocyte recruitment during inflammation
    • Simon, S. I., Green, C. E. (2005) Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu. Rev. Biomed. Eng. 7, 151-185.
    • (2005) Annu. Rev. Biomed. Eng. , vol.7 , pp. 151-185
    • Simon, S.I.1    Green, C.E.2
  • 31
    • 0030996649 scopus 로고    scopus 로고
    • Comparative studies on the extracellular release and biological activity of guinea pig neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11) and defensins
    • Yomogida, S., Nagaoka, I., Yamashita, T. (1997) Comparative studies on the extracellular release and biological activity of guinea pig neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11) and defensins. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 116, 99-107.
    • (1997) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.116 , pp. 99-107
    • Yomogida, S.1    Nagaoka, I.2    Yamashita, T.3
  • 32
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz, T. (2003) Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 710-720
    • Ganz, T.1
  • 33
    • 0028844134 scopus 로고
    • Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
    • Zanetti, M., Gennaro, R., Romeo, D. (1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett. 374, 1-5.
    • (1995) FEBS Lett. , vol.374 , pp. 1-5
    • Zanetti, M.1    Gennaro, R.2    Romeo, D.3
  • 34
    • 0025833471 scopus 로고
    • Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo
    • Ley, K., Gaehtgens, P., Fennie, C., Singer, M. S., Lasky, L. A., Rosen, S. D. (1991) Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo. Blood 77, 2553-2555.
    • (1991) Blood , vol.77 , pp. 2553-2555
    • Ley, K.1    Gaehtgens, P.2    Fennie, C.3    Singer, M.S.4    Lasky, L.A.5    Rosen, S.D.6
  • 35
    • 0032781554 scopus 로고    scopus 로고
    • Integrin signalling in neutrophils and macrophages
    • Berton, G., Lowell, C. A. (1999) Integrin signalling in neutrophils and macrophages. Cell. Signal. 11, 621-635.
    • (1999) Cell. Signal. , vol.11 , pp. 621-635
    • Berton, G.1    Lowell, C.A.2
  • 36
    • 0025255615 scopus 로고
    • Structure and function of the leukocyte adhesion molecules CD11/CD18
    • Arnaout, M. A. (1990) Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 75, 1037-1050.
    • (1990) Blood , vol.75 , pp. 1037-1050
    • Arnaout, M.A.1
  • 37
    • 43349085988 scopus 로고    scopus 로고
    • Lyn-coupled LacCerenriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms
    • Nakayama, H., Yoshizaki, F., Prinetti, A., Sonnino, S., Mauri, L., Takamori, K., Ogawa, H., Iwabuchi, K. (2008) Lyn-coupled LacCerenriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. J. Leukoc. Biol. 83, 728-741.
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 728-741
    • Nakayama, H.1    Yoshizaki, F.2    Prinetti, A.3    Sonnino, S.4    Mauri, L.5    Takamori, K.6    Ogawa, H.7    Iwabuchi, K.8
  • 38
    • 34547905051 scopus 로고    scopus 로고
    • Neutrophil activation via β2 integrins (CD11/CD18): Molecular mechanisms and clinical implications
    • Schymeinsky, J., Mocsai, A., Walzog, B. (2007) Neutrophil activation via β2 integrins (CD11/CD18): molecular mechanisms and clinical implications. Thromb. Haemost. 98, 262-273.
    • (2007) Thromb. Haemost. , vol.98 , pp. 262-273
    • Schymeinsky, J.1    Mocsai, A.2    Walzog, B.3
  • 39
    • 0029888823 scopus 로고    scopus 로고
    • CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils
    • Skubitz, K. M., Campbell, K. D., Skubitz, A. P. (1996) CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J. Leukoc. Biol. 60, 106-117.
    • (1996) J. Leukoc. Biol. , vol.60 , pp. 106-117
    • Skubitz, K.M.1    Campbell, K.D.2    Skubitz, A.P.3
  • 41
    • 17644377258 scopus 로고    scopus 로고
    • How neutrophils kill microbes
    • Segal, A. W. (2005) How neutrophils kill microbes. Annu. Rev. Immunol. 23, 197-223.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 197-223
    • Segal, A.W.1
  • 42
    • 0242713072 scopus 로고    scopus 로고
    • Neutrophil granules and secretory vesicles in inflammation
    • Faurschou, M., Borregaard, N. (2003) Neutrophil granules and secretory vesicles in inflammation. Microbes Infect. 5, 1317-1327.
    • (2003) Microbes Infect. , vol.5 , pp. 1317-1327
    • Faurschou, M.1    Borregaard, N.2
  • 44
    • 0027174208 scopus 로고
    • Control of exocytosis in early neutrophil activation
    • Sengeløv, H., Kjeldsen, L., Borregaard, N. (1993) Control of exocytosis in early neutrophil activation. J. Immunol. 150, 1535-1543.
    • (1993) J. Immunol. , vol.150 , pp. 1535-1543
    • Sengeløv, H.1    Kjeldsen, L.2    Borregaard, N.3
  • 46
    • 0024370068 scopus 로고
    • Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
    • Wilde, C. G., Griffith, J. E., Marra, M. N., Snable, J. L., Scott, R. W. (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem. 264, 11200-11203.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11200-11203
    • Wilde, C.G.1    Griffith, J.E.2    Marra, M.N.3    Snable, J.L.4    Scott, R.W.5
  • 47
    • 0033995146 scopus 로고    scopus 로고
    • Synergistic actions of antibacterial neutrophil defensins and cathelicidins
    • Nagaoka, I., Hirota, S., Yomogida, S., Ohwada, A., Hirata, M. (2000) Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm. Res. 49, 73-79.
    • (2000) Inflamm. Res. , vol.49 , pp. 73-79
    • Nagaoka, I.1    Hirota, S.2    Yomogida, S.3    Ohwada, A.4    Hirata, M.5
  • 48
    • 0027237329 scopus 로고
    • Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis
    • Panyutich, A. V., Panyutich, E. A., Krapivin, V. A., Baturevich, E. A., Ganz, T. (1993) Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J. Lab. Clin. Med. 122, 202-207.
    • (1993) J. Lab. Clin. Med. , vol.122 , pp. 202-207
    • Panyutich, A.V.1    Panyutich, E.A.2    Krapivin, V.A.3    Baturevich, E.A.4    Ganz, T.5
  • 49
    • 80052652326 scopus 로고    scopus 로고
    • Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD
    • Parameswaran, G. I., Sethi, S., Murphy, T. F. (2011) Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD. Chest 140, 611-617.
    • (2011) Chest , vol.140 , pp. 611-617
    • Parameswaran, G.I.1    Sethi, S.2    Murphy, T.F.3
  • 50
    • 33748437790 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor and neutrophils-forgotten mediators of inflammatory disease
    • Eyles, J. L., Roberts, A. W., Metcalf, D., Wicks, I. P. (2006) Granulocyte colony-stimulating factor and neutrophils-forgotten mediators of inflammatory disease. Nat. Clin. Pract. Rheumatol. 2, 500-510.
    • (2006) Nat. Clin. Pract. Rheumatol. , vol.2 , pp. 500-510
    • Eyles, J.L.1    Roberts, A.W.2    Metcalf, D.3    Wicks, I.P.4
  • 51
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan, C. (2006) Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173-182.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 173-182
    • Nathan, C.1
  • 52
    • 4844227764 scopus 로고    scopus 로고
    • Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies
    • Fang, F. C. (2004) Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat. Rev. Microbiol. 2, 820-832.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 820-832
    • Fang, F.C.1
  • 55
    • 33644511380 scopus 로고    scopus 로고
    • An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7
    • Nagaoka, I., Tamura, H., Hirata, M. (2006) An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J. Immunol. 176, 3044-3052.
    • (2006) J. Immunol. , vol.176 , pp. 3044-3052
    • Nagaoka, I.1    Tamura, H.2    Hirata, M.3
  • 56
    • 78649970956 scopus 로고    scopus 로고
    • Evaluation of the effect of α-defensin human neutrophil peptides on neutrophil apoptosis
    • Nagaoka, I., Suzuki, K., Murakami, T., Niyonsaba, F., Tamura, H., Hirata, M. (2010) Evaluation of the effect of α-defensin human neutrophil peptides on neutrophil apoptosis. Int. J. Mol. Med. 26, 925-934.
    • (2010) Int. J. Mol. Med. , vol.26 , pp. 925-934
    • Nagaoka, I.1    Suzuki, K.2    Murakami, T.3    Niyonsaba, F.4    Tamura, H.5    Hirata, M.6
  • 60
    • 0031575752 scopus 로고    scopus 로고
    • Differential effects of a mitogenactivated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors
    • Kuroki, M., O'Flaherty, J. T. (1997) Differential effects of a mitogenactivated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors. Biochem. Biophys. Res. Commun. 232, 474-477.
    • (1997) Biochem. Biophys. Res. Commun. , vol.232 , pp. 474-477
    • Kuroki, M.1    O'Flaherty, J.T.2
  • 61
    • 0034881019 scopus 로고    scopus 로고
    • Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals
    • Ballif, B. A., Blenis, J. (2001) Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 12, 397-408.
    • (2001) Cell Growth Differ. , vol.12 , pp. 397-408
    • Ballif, B.A.1    Blenis, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.