Systems biology of neutrophil differentiation and immune response

Current Opinion in Immunology

Volumn 18, Issue 1, 2006, Pages 54-60

  Theilgaard Mönch, Kim ^a   Porse, Bo T ^a   Borregaard, Niels ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CELL PROTEIN; CHEMOKINE RECEPTOR; CYTOKINE; FC RECEPTOR; GELATINASE; HAPTOGLOBIN; INTERFERON RECEPTOR; INTERLEUKIN RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; OROSOMUCOID; PROTEIN MD 2; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

BONE MARROW CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; GENOMICS; HUMAN; IMMUNE RESPONSE; NEUTROPHIL; NONHUMAN; PROTEOMICS; REVIEW; SKIN DEFECT; SYSTEMS BIOLOGY; TRANSCRIPTION INITIATION; WOUND HEALING;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; EOSINOPHIL GRANULE PROTEINS; HUMANS; IMMUNITY, NATURAL; IMMUNOLOGIC FACTORS; NEUTROPHILS; SYSTEMS BIOLOGY;

EID: 30044434255     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.11.010     Document Type: Review

References (26)

1. K.D. Smith, and H. Bolouri Dissecting innate immune responses with the tools of systems biology Curr Opin Immunol 17 2005 49 54
2. M.W. Kirschner The meaning of systems biology Cell 121 2005 503 504
3. A. Aderem Systems biology: its practice and challenges Cell 121 2005 511 513
4. J.K. Nicholson, E. Holmes, J.C. Lindon, and I.D. Wilson The challenges of modeling mammalian biocomplexity Nat Biotechnol 22 2004 1268 1274
5. A.W. Segal How neutrophils kill microbes Annu Rev Immunol 23 2005 197 223
6. M. Faurschou, and N. Borregaard Neutrophil granules and secretory vesicles in inflammation Microbes Infect 5 2003 1317 1327
7. K. Theilgaard-Monch, S. Knudsen, P. Follin, and N. Borregaard The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing J Immunol 172 2004 7684 7693 This study demonstrates that neutrophil migration to skin lesions in vivo induces a transcriptional programme that supports wound healing, and directs proinflammatory as well as transient anti-apoptotic activity in absence of bacterial contamination.
8. S.D. Kobayashi, J.M. Voyich, G.A. Somerville, K.R. Braughton, H.L. Malech, J.M. Musser, and F.R. DeLeo An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation J Leukoc Biol 73 2003 315 322
9. S.D. Kobayashi, K.R. Braughton, A.R. Whitney, J.M. Voyich, T.G. Schwan, J.M. Musser, and F.R. DeLeo Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils Proc Natl Acad Sci USA 100 2003 10948 10953
10. K. Akashi, X. He, J. Chen, H. Iwasaki, C. Niu, B. Steenhard, J. Zhang, J. Haug, and L. Li Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis Blood 101 2003 383 389
11. K. Theilgaard-Monch, L.C. Jacobsen, R. Borup, T. Rasmussen, M.D. Bjerregaard, F.C. Nielsen, J.B. Cowland, and N. Borregaard The transcriptional program of terminal granulocytic differentiation Blood 105 2005 1785 1796 This study characterizes the transcriptional programme of neutrophil differentiation in vivo by comprehensive microarray analyses of highly purified bone marrow populations representing successive stages of differentiation. These analyses identify novel granule protein candidates and surface receptors of neutrophils. Importantly, the study defines a neutrophil differentiation model, which is characterized by a highly coordinated fail-safe programme that promotes completion of differentiation before cells gain responsiveness toward activating stimuli that accompany infections.
12. G. Lominadze, D.W. Powell, G.C. Luerman, A.J. Link, R.A. Ward, and K.R. McLeish Proteomic analysis of human neutrophil granules Mol Cell Proteomics 4 2005 1503 1521 This study identifies 286 granule protein candidates by mass spectrometry analyses of subcellular fractions enriched in azurophil, specific and gelatinase granules that were isolated from peripheral blood neutrophils.
13. K. Theilgaard-Monch, L.C. Jacobsen, T. Rasmussen, C.U. Niemann, L. Udby, R. Borup, M. Gharib, P.D. Arkwright, A.F. Gombart, and J. Calafat Highly glycosylated {alpha}1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils J Leukoc Biol 78 2005 462 470
14. C.J. Sherr, and J.M. Roberts Living with or without cyclins and cyclin-dependent kinases Genes Dev 18 2004 2699 2711
15. P. Klausen, M.D. Bjerregaard, N. Borregaard, and J.B. Cowland End-stage differentiation of neutrophil granulocytes in vivo is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6 J Leukoc Biol 75 2004 569 578
16. B.T. Porse, T.A. Pedersen, X. Xu, B. Lindberg, U.M. Wewer, L. Friis-Hansen, and C. Nerlov E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo Cell 107 2001 247 258
17. F. D'Alo', L.M. Johansen, E.A. Nelson, H.S. Radomska, E.K. Evans, P. Zhang, C. Nerlov, and D.G. Tenen The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells Blood 102 2003 3163 3171
18. B.T. Porse, D. Bryder, K. Theilgaard-Monch, M.S. Hasemann, K. Anderson, I. Damgaard, S.E. Jacobsen, and C. Nerlov Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage J Exp Med 202 2005 85 96
19. L.M. Johansen, A. Iwama, T.A. Lodie, K. Sasaki, D.W. Felsher, T.R. Golub, and D.G. Tenen c-Myc is a critical target for c/EBPalpha in granulopoiesis Mol Cell Biol 21 2001 3789 3806
20. R.C. O'Hagan, M. Ohh, G. David, I.M. de Alboran, F.W. Alt, W.G. Kaelin Jr., and R.A. DePinho Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression Genes Dev 14 2000 2185 2191
21. W. Yang, J. Shen, M. Wu, M. Arsura, M. FitzGerald, Z. Suldan, D.W. Kim, C.S. Hofmann, S. Pianetti, and R. Romieu-Mourez Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc Oncogene 20 2001 1688 1702
22. S. Gery, A.F. Gombart, Y.K. Fung, and H.P. Koeffler C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis Blood 103 2004 828 835
23. X. Zhang, Y. Kluger, Y. Nakayama, R. Poddar, C. Whitney, A. DeTora, S.M. Weissman, and P.E. Newburger Gene expression in mature neutrophils: early responses to inflammatory stimuli J Leukoc Biol 75 2004 358 372
24. S.D. Kobayashi, J.M. Voyich, K.R. Braughton, and F.R. DeLeo Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes J Immunol 170 2003 3357 3368
25. A.O. Aliprantis, R.B. Yang, M.R. Mark, S. Suggett, B. Devaux, J.D. Radolf, G.R. Klimpel, P. Godowski, and A. Zychlinsky Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 Science 285 1999 736 739
26. S.D. Kobayashi, and F.R. DeLeo An apoptosis differentiation programme in human polymorphonuclear leucocytes Biochem Soc Trans 32 2004 474 476 This is an excellent summary of work on neutrophil apoptosis.