Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria

Science Translational Medicine

Volumn 4, Issue 135, 2012, Pages

  Achtman, Ariel H ^a,b   Pilat, Sandra ^a,b   Law, Charity W ^a,b   Lynn, David J ^c,d,e   Janot, Laure ^c   Mayer, Matt L ^c   Ma, Shuhua ^c   Kindrachuk, Jason ^c   Finlay, B Brett ^f   Brinkman, Fiona S L ^d   Smyth, Gordon K ^a,b   Hancock, Robert E W ^c   Schofield, Louis ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d SIMON FRASER UNIVERSITY   (Canada)

^e TEAGASC   (Ireland)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; INNATE DEFENSE REGULATOR 1 PEPTIDE; INNATE DEFENSE REGULATOR 1018 PEPTIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; POLYPEPTIDE ANTIBIOTIC AGENT; PYRIMETHAMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; INNATE DEFENSE REGULATING PEPTIDE 1018;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN MALARIA; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DOWN REGULATION; DRUG SCREENING; FEMALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PRIORITY JOURNAL; RETICULOCYTE COUNT; SURVIVAL RATE; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; MALARIA; PATHOGENICITY;

ANIMALS; ANTIMALARIALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELLS, CULTURED; FEMALE; MALARIA; MICE; MICE, INBRED C57BL; PLASMODIUM BERGHEI;

EID: 84861477057     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003515     Document Type: Article

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