Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 10, 2013, Pages 1560-1568

  Wu, Nan ^a,b   Sarna, Lindsei K ^a,b   Hwang, Sun Young ^a,b   Zhu, Qingjun ^a,b   Wang, Pengqi ^a,b   Siow, Yaw L ^a,b,c   Karmin, O ^a,b  

^a ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c AGRICULTURE AND AGRI FOOD CANADA   (Canada)

Author keywords

Cholesterol; Fatty liver; HMG CoA reductase; SREBP 2

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL; DNA; LIPID; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; PALMITIC ACID; SPECIFIC PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; FAT INTAKE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID DIET; LIPID STORAGE; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL;

CHOLESTEROL; FATTY LIVER; HMG-COA REDUCTASE; SREBP-2;

ANIMALS; BASE SEQUENCE; CELL LINE; DIETARY FATS; DNA PRIMERS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

MUS;

EID: 84879558602     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.04.024     Document Type: Article

References (38)

1. Golay A., Bobbioni E. The role of dietary fat in obesity. Int. J. Obes. Relat. Metab. Disord. 1997, 21(Suppl. 3):S2-S11.
2. Hariri N., Gougeon R., Thibault L. A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content. Nutr. Res. 2010, 30:632-643.
3. Piers L.S., Walker K.Z., Stoney R.M., Soares M.J., O'Dea K. Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men. Br. J. Nutr. 2003, 90:717-727.
4. Sarna L.K., Wu N., Wang P., Hwang S.Y., Siow Y.L., K.O Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase. Can. J. Physiol. Pharmacol. 2012, 90:155-165.
5. Fungwe T.V., Fox J.E., Cagen L.M., Wilcox H.G., Heimberg M. Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid. J. Lipid Res. 1994, 35:311-318.
6. Hoffler U., Hobbie K., Wilson R., Bai R., Rahman A., Malarkey D., Travlos G., Ghanayem B.I. Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice. Endocrine 2009, 36:311-325.
7. LaRosa J.C., Hunninghake D., Bush D., Criqui M.H., Getz G.S., Gotto A.M., Grundy S.M., Rakita L., Robertson R.M., Weisfeldt M.L., Cleeman J.I. The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. The Task Force on Cholesterol Issues, American Heart Association. Circulation 1990, 81:1721-1733.
8. Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr. Rev. 2007, 65:S57-S63.
9. Marchesini G., Marzocchi R., Agostini F., Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Curr. Opin. Lipidol. 2005, 16:421-427.
10. Puri P., Baillie R.A., Wiest M.M., Mirshahi F., Choudhury J., Cheung O., Sargeant C., Contos M.J., Sanyal A.J. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
11. Caballero F., Fernandez A., De Lacy A.M., Fernandez-Checa J.C., Caballeria J., Garcia-Ruiz C. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J. Hepatol. 2009, 50:789-796.
12. Simonen P., Kotronen A., Hallikainen M., Sevastianova K., Makkonen J., Hakkarainen A., Lundbom N., Miettinen T.A., Gylling H., Yki-Jarvinen H. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. J. Hepatol. 2011, 54:153-159.
13. Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
14. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109:1125-1131.
15. Horton J.D., Shimomura I., Brown M.S., Hammer R.E., Goldstein J.L., Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 1998, 101:2331-2339.
16. Lin C.C., Yin M.C. Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet. Br. J. Nutr. 2008, 99:37-43.
17. Safwat G.M., Pisano S., D'Amore E., Borioni G., Napolitano M., Kamal A.A., Ballanti P., Botham K.M., Bravo E. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect?. Nutrition 2009, 25:1157-1168.
18. Gaemers I.C., Stallen J.M., Kunne C., Wallner C., van Werven J., Nederveen A., Lamers W.H. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim. Biophys. Acta 2011, 1812:447-458.
19. Goh E.H., Heimberg M. Effects of free fatty acids on activity of hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase and on secretion of triglyceride and cholesterol by liver. J. Biol. Chem. 1977, 252:2822-2826.
20. Salam W.H., Wilcox H.G., Cagen L.M., Heimberg M. Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase. Biochem. J. 1989, 258:563-568.
21. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957, 226:497-509.
22. Gibbons G.F. A comparison of in-vitro models to study hepatic lipid and lipoprotein metabolism. Curr. Opin. Lipidol. 1994, 5:191-199.
23. Javitt N.B. Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. FASEB J. 1990, 4:161-168.
24. Joshi-Barve S., Barve S.S., Amancherla K., Gobejishvili L., Hill D., Cave M., Hote P., McClain C.J. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 2007, 46:823-830.
25. Wu N., Sarna L.K., Siow Y.L., K.O Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 300:R635-R643.
26. Woo C.W., Siow Y.L., Pierce G.N., Choy P.C., Minuk G.Y., Mymin D., K.O Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E1002-E1010.
27. Wu N., Siow Y.L., K.O Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine beta-synthase expression in the kidney. J. Biol. Chem. 2010, 285:18225-18233.
28. Woo C.W., Siow Y.L., K.O Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation. J. Biol. Chem. 2008, 283:1282-1292.
29. Yang T., Espenshade P.J., Wright M.E., Yabe D., Gong Y., Aebersold R., Goldstein J.L., Brown M.S. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 2002, 110:489-500.
30. Gould R.G., Taylor C.B., Hagerman J.S., Warner I., Campbell D.J. Cholesterol metabolism. I. Effect of dietary cholesterol on the synthesis of cholesterol in dog tissue in vitro. J. Biol. Chem. 1953, 201:519-528.
31. Siperstein M.D., Fagan V.M. Feedback control of mevalonate synthesis by dietary cholesterol. J. Biol. Chem. 1966, 241:602-609.
32. Yabe D., Brown M.S., Goldstein J.L. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:12753-12758.
33. Sato R., Inoue J., Kawabe Y., Kodama T., Takano T., Maeda M. Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. J. Biol. Chem. 1996, 271:26461-26464.
34. Kang Q., Chen A. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 2009, 150:5384-5394.
35. Min H.K., Kapoor A., Fuchs M., Mirshahi F., Zhou H., Maher J., Kellum J., Warnick R., Contos M.J., Sanyal A.J. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic Fatty liver disease. Cell Metab. 2012, 15:665-674.
36. Maxwell K.N., Fisher E.A., Breslow J.L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:2069-2074.
37. Jeong H.J., Lee H.S., Kim K.S., Kim Y.K., Yoon D., Park S.W. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2. J. Lipid Res. 2008, 49:399-409.
38. Dong B., Wu M., Li H., Kraemer F.B., Adeli K., Seidah N.G., Park S.W., Liu J. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. J. Lipid Res. 2010, 51:1486-1495.