Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 5 51-5, 2005, Pages

  Woo, Connie W H ^a   Siow, Yaw L ^a,b   Pierce, Grant N ^a   Choy, Patrick C ^b   Minuk, Gerald Y ^a   Mymin, David ^a,b   O, Karmin ^a,b,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c ST BONIFACE GENERAL HOSPITAL   (Canada)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase; CAMP response element binding protein; Homocysteine; Nuclear factor Y; Sterol regulatory element binding protein 2

Indexed keywords

CHOLESTEROL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; MESSENGER RNA; METHIONINE; NUCLEAR FACTOR; NUCLEAR FACTOR Y; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERHOMOCYSTEINEMIA; LIPID STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; PROTEIN EXPRESSION; RAT; RISK FACTOR; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ACYL COENZYME A; ANIMALS; CHOLESTEROL; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; LIPID METABOLISM; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 17544374598     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00518.2004     Document Type: Article

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