Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein

Neuroscience

Volumn 247, Issue , 2013, Pages 227-233

  Wang, Jisheng ^a   Wu, Fengming ^b   Shi, Chun ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

sitosterol; Alzheimer's disease; Amyloid precursor protein; Cholesterol; Membrane fluidity

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CHOLESTEROL; PRESENILIN 1; SITOSTEROL;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; HIPPOCAMPUS; LIPID RAFT; MEMBRANE FLUIDITY; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

Β-SECRETASE-1; Β-SITOSTEROL; 2-HYDROXYPROPYL-Β-CYCLODEXTRIN; 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE; AΒ; AD; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; APP; BACE-1; BETA AMYLOID; BS; CHAPS; CHOLESTEROL; DMEM; DULBECCO'S MINIMUM ESSENTIAL MEDIUM; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HPΒCD; IGG-HRP; IMMUNOGLOBULIN G-HORSERADISH PEROXIDASE; MEMBRANE FLUIDITY; PBST; PHOSPHATE-BUFFERED SALINE WITH TWEEN 20; TMA-DPH; TRIMETHYLAMINE-DIPHENYLHEXATRIENE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; MICE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SITOSTEROLS;

EID: 84879543011     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.05.022     Document Type: Article

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