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Volumn 38, Issue 1, 2004, Pages 91-98

The Role of Cholesterol and Statins in Alzheimer's Disease

Author keywords

Alzheimer's disease; Cholesterol; Statins

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

EID: 0347623331     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D104     Document Type: Review
Times cited : (60)

References (43)
  • 2
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 1998;88:1337-42.
    • (1998) Am J Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 3
    • 0027511389 scopus 로고
    • The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
    • De Lacoste MC, White CL 3rd. The role of cortical connectivity in Alzheimer's disease pathogenesis: a review and model system. Neurobiol Aging 1993;14:1-16.
    • (1993) Neurobiol Aging , vol.14 , pp. 1-16
    • De Lacoste, M.C.1    White III, C.L.2
  • 4
    • 0032894121 scopus 로고    scopus 로고
    • The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease
    • Delacourte A, David JP, Sergeant N, Buee L, Wattez A, Vermersch P, et al. The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology 1999;52:1158-65.
    • (1999) Neurology , vol.52 , pp. 1158-1165
    • Delacourte, A.1    David, J.P.2    Sergeant, N.3    Buee, L.4    Wattez, A.5    Vermersch, P.6
  • 5
    • 0030660554 scopus 로고    scopus 로고
    • Neuropathological diagnosis of Alzheimer's disease: A perspective from longitudinal clinicopathological studies
    • Dickson DW. Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 1997;18(4 suppl):S21-6.
    • (1997) Neurobiol Aging , vol.18 , Issue.4 SUPPL.
    • Dickson, D.W.1
  • 6
    • 0022558388 scopus 로고
    • New perspectives on Alzheimer's disease
    • Price DL. New perspectives on Alzheimer's disease. Annu Rev Neurosci 1986;9:489-512.
    • (1986) Annu Rev Neurosci , vol.9 , pp. 489-512
    • Price, D.L.1
  • 7
    • 0035030267 scopus 로고    scopus 로고
    • Alzheimer's disease and related disorders
    • Raskind MA, Peskkind ER. Alzheimer's disease and related disorders. Med Clin North Am 2001;85:803-17.
    • (2001) Med Clin North Am , vol.85 , pp. 803-817
    • Raskind, M.A.1    Peskkind, E.R.2
  • 8
    • 0034603520 scopus 로고    scopus 로고
    • Vascular risk factors for Alzheimer's disease: An epidemiologic perspective
    • Breteler MM. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 2000;21:153-60.
    • (2000) Neurobiol Aging , vol.21 , pp. 153-160
    • Breteler, M.M.1
  • 10
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E, Saunders A, Strittmatter W, Schmechel D, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.1    Saunders, A.2    Strittmatter, W.3    Schmechel, D.4    Gaskell, P.C.5    Small, G.W.6
  • 12
    • 0028986408 scopus 로고
    • Fibrillogenesis in Alzheimer's disease of amyloid B peptides and apolipoprotein E
    • Castano EM, Prelli F, Wisniewski T, Golabek A, Kumar RA, Soto C, et al. Fibrillogenesis in Alzheimer's disease of amyloid B peptides and apolipoprotein E. Biochem J 1995;306:599-604.
    • (1995) Biochem J , vol.306 , pp. 599-604
    • Castano, E.M.1    Prelli, F.2    Wisniewski, T.3    Golabek, A.4    Kumar, R.A.5    Soto, C.6
  • 14
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxesterol in the circulation
    • Bjorkhem I, Lutjohann D, Diczfalusy U, Stahle L, Ahlborg G, Wahren J. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxesterol in the circulation. J Lipid Res 1998;39:1594-600.
    • (1998) J Lipid Res , vol.39 , pp. 1594-1600
    • Bjorkhem, I.1    Lutjohann, D.2    Diczfalusy, U.3    Stahle, L.4    Ahlborg, G.5    Wahren, J.6
  • 15
    • 0032892176 scopus 로고    scopus 로고
    • Removal of cholesterol from extrahepatic sources by oxidative mechanisms
    • Bjorkhem I, Diczfalusy U, Lutjohann D. Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr Opin Lipidol 1999;10:161-5.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 161-165
    • Bjorkhem, I.1    Diczfalusy, U.2    Lutjohann, D.3
  • 16
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol mechanism in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, Diczfalusy U, et al. Cholesterol mechanism in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci 1996;93:9799-804.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5    Diczfalusy, U.6
  • 17
    • 0034595080 scopus 로고    scopus 로고
    • High density lipoprotein inhibits assembly of amyloid beta peptides into fibrils
    • Olesen OF, Dago L. High density lipoprotein inhibits assembly of amyloid beta peptides into fibrils. Biochem Biophys Res Commun 2000;270:62-6.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 62-66
    • Olesen, O.F.1    Dago, L.2
  • 18
  • 19
    • 0004821712 scopus 로고    scopus 로고
    • Plasma 24S-hydroxy-cholesterol; a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease
    • Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, Rao ML, et al. Plasma 24S-hydroxy-cholesterol; a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. Neuroreport 2000;11:1959-62.
    • (2000) Neuroreport , vol.11 , pp. 1959-1962
    • Papassotiropoulos, A.1    Lutjohann, D.2    Bagli, M.3    Locatelli, S.4    Jessen, F.5    Rao, M.L.6
  • 20
    • 0036250622 scopus 로고    scopus 로고
    • Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid
    • Teunissen CE, deVente J, Steinbusch HWM, DeBruijn C. Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid. Neurobiol Aging 2002;23:485-508.
    • (2002) Neurobiol Aging , vol.23 , pp. 485-508
    • Teunissen, C.E.1    DeVente, J.2    Steinbusch, H.W.M.3    DeBruijn, C.4
  • 22
    • 0031026879 scopus 로고    scopus 로고
    • Atherosclerosis, lipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
    • Hofman A, Ott A, Breteler MM, Bots MC, Slooter AJC, Van Harskamp F, et al. Atherosclerosis, lipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 1997;349:151-4.
    • (1997) Lancet , vol.349 , pp. 151-154
    • Hofman, A.1    Ott, A.2    Breteler, M.M.3    Bots, M.C.4    Slooter, A.J.C.5    Van Harskamp, F.6
  • 23
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
    • Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology 1995;45:1092-6.
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3    Schellenberg, G.D.4    Yu, C.5    Larson, E.B.6
  • 25
    • 0037031125 scopus 로고    scopus 로고
    • Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    • Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, et al. Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med 2002;137:149-55.
    • (2002) Ann Intern Med , vol.137 , pp. 149-155
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3    Hanninen, T.4    Hallikainen, M.5    Alhainen, K.6
  • 26
  • 27
    • 0032146978 scopus 로고    scopus 로고
    • The importance of inflammatory mechanisms in Alzheimer's disease
    • McGeer EG, McGeer PL. The importance of inflammatory mechanisms in Alzheimer's disease. Exp Gerontol 1998;33:371-8.
    • (1998) Exp Gerontol , vol.33 , pp. 371-378
    • McGeer, E.G.1    McGeer, P.L.2
  • 28
    • 0035830376 scopus 로고    scopus 로고
    • Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selection in an in vivo model of acute inflammation
    • Cockerill GW, Huehns TW, Weerasinghe A, Stocker C, Lerch PG, Miller NE, et al. Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selection in an in vivo model of acute inflammation. Circulation 2001;103:108-12.
    • (2001) Circulation , vol.103 , pp. 108-112
    • Cockerill, G.W.1    Huehns, T.W.2    Weerasinghe, A.3    Stocker, C.4    Lerch, P.G.5    Miller, N.E.6
  • 30
    • 0033549840 scopus 로고    scopus 로고
    • Drug treatment of lipid disorders
    • Knopp R. Drug treatment of lipid disorders. N Engl J Med 1999;341:498-511.
    • (1999) N Engl J Med , vol.341 , pp. 498-511
    • Knopp, R.1
  • 31
    • 0034701033 scopus 로고    scopus 로고
    • HMGCoa reductase inhibitors (statins); a promising approach to stroke prevention
    • Hess D, Demchuk A, Brass L. HMGCoa reductase inhibitors (statins); a promising approach to stroke prevention. Neurology 2000;54:790-6.
    • (2000) Neurology , vol.54 , pp. 790-796
    • Hess, D.1    Demchuk, A.2    Brass, L.3
  • 33
    • 0034603525 scopus 로고    scopus 로고
    • Aberrant expression of nitric oxide synthase III in Alzheimer's disease: Relevance to cerebral vasculopathy and neuorodegeneration
    • De la Monte SM, Lu B, Sohn Y, Etienne D, Kraft J, Ganju N, et al. Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neuorodegeneration. Neurobiol Aging 2000;21:309-19.
    • (2000) Neurobiol Aging , vol.21 , pp. 309-319
    • De La Monte, S.M.1    Lu, B.2    Sohn, Y.3    Etienne, D.4    Kraft, J.5    Ganju, N.6
  • 34
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kelhnan W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000;57:1439-43.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kelhnan, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 36
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agent, indication bias, and the risk of dementia in community-dwelling elderly people
    • Rockwood K, Kirkland S, Hogan DB, McKnight C, Merry H, Verrault R. Use of lipid-lowering agent, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol 2002;59:223-7.
    • (2002) Arch Neurol , vol.59 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3    McKnight, C.4    Merry, H.5    Verrault, R.6
  • 37
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use and cognitive function in older women
    • Yaffe K, Barrett-Conner E, Lin F, Grady D. Serum lipoprotein levels, statin use and cognitive function in older women. Arch Neurol 2002;59:378-84.
    • (2002) Arch Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Conner, E.2    Lin, F.3    Grady, D.4
  • 38
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • Hajjar I, Schumpert J, Hirth V, Wieland D, Eleazer GP. The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. J Gerontol A Biol Sci Med Sci 2002;57:408-14.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57 , pp. 408-414
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3    Wieland, D.4    Eleazer, G.P.5
  • 40
    • 0036128358 scopus 로고    scopus 로고
    • Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia
    • Locatelli S, Lutjohann D, Schmidt HHJ, Otto C, Beisiegel U, von Bergmann K. Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia. Arch Neurol 2002;59:213-6.
    • (2002) Arch Neurol , vol.59 , pp. 213-216
    • Locatelli, S.1    Lutjohann, D.2    Schmidt, H.H.J.3    Otto, C.4    Beisiegel, U.5    Von Bergmann, K.6
  • 41
    • 0036714243 scopus 로고    scopus 로고
    • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26 week, randomized, placebo-controlled, double blind trial
    • Simons M, Schwarzler F, Lutjohann D, von Bergmann K, Beyreuther K, Dichgans J, et al. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26 week, randomized, placebo-controlled, double blind trial. Ann Neurol 2002;52:346-50.
    • (2002) Ann Neurol , vol.52 , pp. 346-350
    • Simons, M.1    Schwarzler, F.2    Lutjohann, D.3    Von Bergmann, K.4    Beyreuther, K.5    Dichgans, J.6
  • 42
    • 85039569560 scopus 로고    scopus 로고
    • February. National Institutes of Health
    • Alzheimer's Disease Lipitor treatment trial. February 2003. National Institutes of Health. www.clinicaltrials.gov/ct/action/GetStudy.htm (ac cessed 2003 Jun 25).
    • (2003) Alzheimer's Disease Lipitor Treatment Trial


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.