Generation of Reactive Oxygen Species by Polyenylpyrroles Derivatives Causes DNA Damage Leading to G2/M Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Hua, Kuo Feng ^a   Liao, Pei Chun ^a   Fang, Zhanxiong ^b   Yang, Feng Ling ^c   Yang, Yu Liang ^d   Chen, Yi Lin ^a   Chiu, Yi Chich ^a   Liu, May Lan ^e   Lam, Yulin ^b   Wu, Shih Hsiung ^c  

^a NATIONAL ILAN UNIVERSITY   (Taiwan)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^e TOKO UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; AUXARCONJUGATIN A; CASPASE; CYTOCHROME C; CYTOCHROME P450 1A1; POLYENYLPYRROLE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL LEVEL; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; CYTOCHROMES C; DNA DAMAGE; FEMALE; G2 PHASE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; MOUTH NEOPLASMS; OXIDATIVE STRESS; PYRONES; PYRROLES; REACTIVE OXYGEN SPECIES; TAIWAN;

MUS MUSCULUS;

EID: 84879522916     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067603     Document Type: Article

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