Oral benzo[a]pyrene-induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype

International Journal of Cancer

Volumn 127, Issue 10, 2010, Pages 2334-2350

  Shi, Zhanquan ^a   Dragin, Nadine ^a,e   Miller, Marian L ^a   Stringer, Keith F ^b   Johansson, Elisabet ^a   Chen, Jing ^a   Uno, Shigeyuki ^a,f   Gonzalez, Frank J ^c   Rubio, Carlos A ^d   Nebert, Daniel W ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e CNRS   (France)

^f NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

adenocarcinoma of proximal small intestine; CYP1 enzymes; Cyp1a1 gene; Cyp1b1 gene; immunoglobulin secreting tumor; nonagouti locus; Nr0b2 tumor suppressor gene; Olfr genes; oral benzo a pyrene; Rab30 oncogene; squamous cell carcinoma of preputial gland duct; Xist gene

Indexed keywords

BENZO[A]PYRENE; COMPLEMENTARY DNA; MESSENGER RNA; CYP1B1 PROTEIN, MOUSE; CYTOCHROME P450 1A1; UNSPECIFIC MONOOXYGENASE;

ADENOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYP1 GENE; CYP1A1 GENE; CYP1B1 GENE; DOWN REGULATION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE; GENE CONTROL; GENE INTERACTION; GENE NROB2; GENE OVEREXPRESSION; GENE SILENCING; GENETIC VARIABILITY; GENOTYPE; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN KAPPA CHAIN GENE; KNOCKOUT MOUSE; LIVER; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE RAB30; PREPUTIAL GLAND; PRIORITY JOURNAL; SMALL INTESTINE CARCINOMA; SQUAMOUS CELL CARCINOMA; SUBCUTANEOUS TISSUE TUMOR; TISSUE SECTION; TUMOR SUPPRESSOR GENE; UPREGULATION; WILD TYPE; XIST GENE; Y CHROMOSOME; ADENOCARCINOMA; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETICS; INBREEDING; INTESTINE TUMOR; MALE; MOUSE MUTANT; ORAL DRUG ADMINISTRATION; PATHOLOGY; SCENT GLAND; SMALL INTESTINE;

ADENOCARCINOMA; ADMINISTRATION, ORAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CARCINOMA, SQUAMOUS CELL; CYTOCHROME P-450 CYP1A1; FEMALE; GENOTYPE; INBREEDING; INTESTINAL NEOPLASMS; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SCENT GLANDS;

EID: 78049510874     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25222     Document Type: Article

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